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Structure-function relationship studies of ammodytoxins and ammodytins by protein engineering.

Acta chimica Slovenica

Pungerčar J, Znidaršič PP, Petan T.
PMID: 24061113
Acta Chim Slov. 2011 Dec;58(4):660-70.

Ammodytoxins (Atxs) and ammodytins (Atns) are group IIA phospholipases A2 (sPLA2s) and their homologues, secreted by venom glands of the nose-horned viper (Vipera a. ammodytes). The molecular mechanisms underlying their various pharmacological effects, including neurotoxicity, myotoxicity and anticoagulant activity,...

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Pungerčar J, Znidaršič PP, Petan T. Structure-function relationship studies of ammodytoxins and ammodytins by protein engineering. Acta Chim Slov. 2011;58(4):660-70
Pungerčar, J., Znidaršič, P. P., & Petan, T. (2011). Structure-function relationship studies of ammodytoxins and ammodytins by protein engineering. Acta chimica Slovenica, 58(4), 660-70.
Pungerčar, Jože, et al. "Structure-function relationship studies of ammodytoxins and ammodytins by protein engineering." Acta chimica Slovenica vol. 58,4 (2011): 660-70.
Pungerčar J, Znidaršič PP, Petan T. Structure-function relationship studies of ammodytoxins and ammodytins by protein engineering. Acta Chim Slov. 2011 Dec;58(4):660-70. PMID: 24061113.
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Platelet total PLA2 activity, serum oxidative level and plasma Cu/Zn ratio: a vicious cycle with a potential role to monitor MCI and Alzheimer's disease progression.

Rejuvenation research

Balietti M, Casoli T, Giacconi R, Giuli C.
PMID: 34913745
Rejuvenation Res. 2021 Dec 16; doi: 10.1089/rej.2021.0020. Epub 2021 Dec 16.

Alzheimer's disease (AD) has no cure, mainly because of late diagnosis. Early diagnostic biomarkers are crucial. Phospholipases A2 (PLA2) are hydrolases with several functions in the brain, nevertheless their deregulation contributes to neurodegeneration. We evaluated platelet total PLA2 activity...

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Balietti M, Casoli T, Giacconi R, et al. Platelet total PLA2 activity, serum oxidative level and plasma Cu/Zn ratio: a vicious cycle with a potential role to monitor MCI and Alzheimer's disease progression. Rejuvenation Res. 2021;doi: 10.1089/rej.2021.0020.
Balietti, M., Casoli, T., Giacconi, R., & Giuli, C. (2021). Platelet total PLA2 activity, serum oxidative level and plasma Cu/Zn ratio: a vicious cycle with a potential role to monitor MCI and Alzheimer's disease progression. Rejuvenation research, . https://doi.org/10.1089/rej.2021.0020
Balietti, Marta, et al. "Platelet total PLA2 activity, serum oxidative level and plasma Cu/Zn ratio: a vicious cycle with a potential role to monitor MCI and Alzheimer's disease progression." Rejuvenation research vol. (2021). doi: https://doi.org/10.1089/rej.2021.0020
Balietti M, Casoli T, Giacconi R, Giuli C. Platelet total PLA2 activity, serum oxidative level and plasma Cu/Zn ratio: a vicious cycle with a potential role to monitor MCI and Alzheimer's disease progression. Rejuvenation Res. 2021 Dec 16; doi: 10.1089/rej.2021.0020. Epub 2021 Dec 16. PMID: 34913745.
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Antimalarial activity of basic phospholipases A.

Toxicon: X

Vitorino KA, Alfonso JJ, Gómez AF, Santos APA, Antunes YR, Caldeira CADS, Gómez CV, Teles CBG, Soares AM, Calderon LA.
PMID: 32885164
Toxicon X. 2020 Aug 08;8:100056. doi: 10.1016/j.toxcx.2020.100056. eCollection 2020 Dec.

Malaria is a parasitic infectious disease and was responsible for 400.000 deaths in 2018.

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Vitorino KA, Alfonso JJ, Gómez AF, et al. Antimalarial activity of basic phospholipases A. Toxicon X. 2020;8:100056doi: 10.1016/j.toxcx.2020.100056.
Vitorino, K. A., Alfonso, J. J., Gómez, A. F., Santos, A. P. A., Antunes, Y. R., Caldeira, C. A. D. S., Gómez, C. V., Teles, C. B. G., Soares, A. M., & Calderon, L. A. (2020). Antimalarial activity of basic phospholipases A. Toxicon: X, 8100056. https://doi.org/10.1016/j.toxcx.2020.100056
Vitorino, Keila A, et al. "Antimalarial activity of basic phospholipases A." Toxicon: X vol. 8 (2020): 100056. doi: https://doi.org/10.1016/j.toxcx.2020.100056
Vitorino KA, Alfonso JJ, Gómez AF, Santos APA, Antunes YR, Caldeira CADS, Gómez CV, Teles CBG, Soares AM, Calderon LA. Antimalarial activity of basic phospholipases A. Toxicon X. 2020 Aug 08;8:100056. doi: 10.1016/j.toxcx.2020.100056. eCollection 2020 Dec. PMID: 32885164; PMCID: PMC7451622.
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Human Secretary Phospholipase A2 Mutations and Their Clinical Implications.

Journal of inflammation research

Khan MI, Hariprasad G.
PMID: 32982370
J Inflamm Res. 2020 Sep 16;13:551-561. doi: 10.2147/JIR.S269557. eCollection 2020.

Phospholipases A2 (PLA

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Khan MI, Hariprasad G. Human Secretary Phospholipase A2 Mutations and Their Clinical Implications. J Inflamm Res. 2020;13:551-561doi: 10.2147/JIR.S269557.
Khan, M. I., & Hariprasad, G. (2020). Human Secretary Phospholipase A2 Mutations and Their Clinical Implications. Journal of inflammation research, 13551-561. https://doi.org/10.2147/JIR.S269557
Khan, Mohd Imran, and Hariprasad, Gururao. "Human Secretary Phospholipase A2 Mutations and Their Clinical Implications." Journal of inflammation research vol. 13 (2020): 551-561. doi: https://doi.org/10.2147/JIR.S269557
Khan MI, Hariprasad G. Human Secretary Phospholipase A2 Mutations and Their Clinical Implications. J Inflamm Res. 2020 Sep 16;13:551-561. doi: 10.2147/JIR.S269557. eCollection 2020. PMID: 32982370; PMCID: PMC7502393.
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Isolation and structural characterization of bioactive compound from .

Toxicon: X

González Rodríguez II, Francisco AF, Moreira-Dill LS, Quintero A, Guimarães CLS, Fernandes CAH, Takeda AAS, Zanchi FB, Caldeira CAS, Pereira PS, Fontes MRM, Zuliani JP, Soares AM.
PMID: 32613196
Toxicon X. 2020 Jun 20;7:100049. doi: 10.1016/j.toxcx.2020.100049. eCollection 2020 Sep.

A bioactive compound isolated from the stem extract of

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González Rodríguez II, Francisco AF, Moreira-Dill LS, et al. Isolation and structural characterization of bioactive compound from . Toxicon X. 2020;7:100049doi: 10.1016/j.toxcx.2020.100049.
González Rodríguez, I. I., Francisco, A. F., Moreira-Dill, L. S., Quintero, A., Guimarães, C. L. S., Fernandes, C. A. H., Takeda, A. A. S., Zanchi, F. B., Caldeira, C. A. S., Pereira, P. S., Fontes, M. R. M., Zuliani, J. P., & Soares, A. M. (2020). Isolation and structural characterization of bioactive compound from . Toxicon: X, 7100049. https://doi.org/10.1016/j.toxcx.2020.100049
González Rodríguez, Isela I, et al. "Isolation and structural characterization of bioactive compound from ." Toxicon: X vol. 7 (2020): 100049. doi: https://doi.org/10.1016/j.toxcx.2020.100049
González Rodríguez II, Francisco AF, Moreira-Dill LS, Quintero A, Guimarães CLS, Fernandes CAH, Takeda AAS, Zanchi FB, Caldeira CAS, Pereira PS, Fontes MRM, Zuliani JP, Soares AM. Isolation and structural characterization of bioactive compound from . Toxicon X. 2020 Jun 20;7:100049. doi: 10.1016/j.toxcx.2020.100049. eCollection 2020 Sep. PMID: 32613196; PMCID: PMC7322210.
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Corrigendum to "Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2" [Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864/6 2019 941-956].

Biochimica et biophysica acta. Molecular and cell biology of lipids

Nikolaou A, Kokotou MG, Vasilakaki S, Kokotos G.
PMID: 31221540
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Nov;1864(11):1681. doi: 10.1016/j.bbalip.2019.06.009. Epub 2019 Jun 17.

No abstract available.

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Nikolaou A, Kokotou MG, Vasilakaki S, et al. Corrigendum to "Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2" [Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864/6 2019 941-956]. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864(11):1681doi: 10.1016/j.bbalip.2019.06.009.
Nikolaou, A., Kokotou, M. G., Vasilakaki, S., & Kokotos, G. (2019). Corrigendum to "Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2" [Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864/6 2019 941-956]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864(11), 1681. https://doi.org/10.1016/j.bbalip.2019.06.009
Nikolaou, Aikaterini, et al. "Corrigendum to "Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2" [Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864/6 2019 941-956]." Biochimica et biophysica acta. Molecular and cell biology of lipids vol. 1864,11 (2019): 1681. doi: https://doi.org/10.1016/j.bbalip.2019.06.009
Nikolaou A, Kokotou MG, Vasilakaki S, Kokotos G. Corrigendum to "Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2" [Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864/6 2019 941-956]. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Nov;1864(11):1681. doi: 10.1016/j.bbalip.2019.06.009. Epub 2019 Jun 17. PMID: 31221540; PMCID: PMC8445307.
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Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells.

Cytotechnology

He C, Liu Z, Huang J, Liu T.
PMID: 29101583
Cytotechnology. 2018 Feb;70(1):431-438. doi: 10.1007/s10616-017-0158-4. Epub 2017 Nov 03.

The present study was aimed to investigate the effect of 28-homobrassinolide on leukotriene synthesis in the 2H3 cells. Cell viability was determined by using sulforhodamine B (SRB) assay. Leukotriene C

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He C, Liu Z, Huang J, et al. Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells. Cytotechnology. 2017;70(1):431-438doi: 10.1007/s10616-017-0158-4.
He, C., Liu, Z., Huang, J., & Liu, T. (2018). Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells. Cytotechnology, 70(1), 431-438. https://doi.org/10.1007/s10616-017-0158-4
He, Chuan, et al. "Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells." Cytotechnology vol. 70,1 (2018): 431-438. doi: https://doi.org/10.1007/s10616-017-0158-4
He C, Liu Z, Huang J, Liu T. Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells. Cytotechnology. 2018 Feb;70(1):431-438. doi: 10.1007/s10616-017-0158-4. Epub 2017 Nov 03. PMID: 29101583; PMCID: PMC5809672.
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Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia.

PeerJ

Fernández Culma M, Andrés Pereañez J, Núñez Rangel V, Lomonte B.
PMID: 24498576
PeerJ. 2014 Jan 22;2:e246. doi: 10.7717/peerj.246. eCollection 2014.

Bothrops punctatus is an endangered, semi-arboreal pitviper species distributed in Panamá, Colombia, and Ecuador, whose venom is poorly characterized. In the present work, the protein composition of this venom was profiled using the 'snake venomics' analytical strategy. Decomplexation of...

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Fernández Culma M, Andrés Pereañez J, Núñez Rangel V, et al. Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia. PeerJ. 2014;2:e246doi: 10.7717/peerj.246.
Fernández Culma, M., Andrés Pereañez, J., Núñez Rangel, V., & Lomonte, B. (2014). Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia. PeerJ, 2e246. https://doi.org/10.7717/peerj.246
Fernández Culma, Maritza, et al. "Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia." PeerJ vol. 2 (2014): e246. doi: https://doi.org/10.7717/peerj.246
Fernández Culma M, Andrés Pereañez J, Núñez Rangel V, Lomonte B. Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia. PeerJ. 2014 Jan 22;2:e246. doi: 10.7717/peerj.246. eCollection 2014. PMID: 24498576; PMCID: PMC3912449.
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Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?.

Acta chimica Slovenica

Lomonte B, Gutiérrez JM.
PMID: 24061112
Acta Chim Slov. 2011 Dec;58(4):647-59.

Phospholipases A2 (PLA2s) are abundant components in snake venoms, which play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic effects, present in Viperidae venoms. These PLA2s are subdivided into catalytically-active (Asp49) PLA2s, and catalytically-inactive...

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Lomonte B, Gutiérrez JM. Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?. Acta Chim Slov. 2011;58(4):647-59
Lomonte, B., & Gutiérrez, J. M. (2011). Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?. Acta chimica Slovenica, 58(4), 647-59.
Lomonte, Bruno, and Gutiérrez, José María. "Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?." Acta chimica Slovenica vol. 58,4 (2011): 647-59.
Lomonte B, Gutiérrez JM. Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?. Acta Chim Slov. 2011 Dec;58(4):647-59. PMID: 24061112.
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Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment.

Frontiers in genetics

Hermann PM, Watson SN, Wildering WC.
PMID: 25538730
Front Genet. 2014 Dec 04;5:419. doi: 10.3389/fgene.2014.00419. eCollection 2014.

The aging brain undergoes a range of changes varying from subtle structural and physiological changes causing only minor functional decline under healthy normal aging conditions, to severe cognitive or neurological impairment associated with extensive loss of neurons and circuits...

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Hermann PM, Watson SN, Wildering WC. Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment. Front Genet. 2014;5:419doi: 10.3389/fgene.2014.00419.
Hermann, P. M., Watson, S. N., & Wildering, W. C. (2014). Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment. Frontiers in genetics, 5419. https://doi.org/10.3389/fgene.2014.00419
Hermann, Petra M, et al. "Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment." Frontiers in genetics vol. 5 (2014): 419. doi: https://doi.org/10.3389/fgene.2014.00419
Hermann PM, Watson SN, Wildering WC. Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment. Front Genet. 2014 Dec 04;5:419. doi: 10.3389/fgene.2014.00419. eCollection 2014. PMID: 25538730; PMCID: PMC4255604.
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Alpha-type phospholipase A.

The journal of venomous animals and toxins including tropical diseases

Santos-Filho NA, Santos CT.
PMID: 28344595
J Venom Anim Toxins Incl Trop Dis. 2017 Mar 23;23:19. doi: 10.1186/s40409-017-0110-2. eCollection 2017.

It is of popular and scientific knowledge that toxins from snake venom (among them the PLA

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Santos-Filho NA, Santos CT. Alpha-type phospholipase A. J Venom Anim Toxins Incl Trop Dis. 2017;23:19doi: 10.1186/s40409-017-0110-2.
Santos-Filho, N. A., & Santos, C. T. (2017). Alpha-type phospholipase A. The journal of venomous animals and toxins including tropical diseases, 2319. https://doi.org/10.1186/s40409-017-0110-2
Santos-Filho, Norival A, and Santos, Claudia T. "Alpha-type phospholipase A." The journal of venomous animals and toxins including tropical diseases vol. 23 (2017): 19. doi: https://doi.org/10.1186/s40409-017-0110-2
Santos-Filho NA, Santos CT. Alpha-type phospholipase A. J Venom Anim Toxins Incl Trop Dis. 2017 Mar 23;23:19. doi: 10.1186/s40409-017-0110-2. eCollection 2017. PMID: 28344595; PMCID: PMC5364564.
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Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines.

The journal of venomous animals and toxins including tropical diseases

Prinholato da Silva C, Costa TR, Paiva RM, Cintra AC, Menaldo DL, Antunes LM, Sampaio SV.
PMID: 26539212
J Venom Anim Toxins Incl Trop Dis. 2015 Nov 03;21:44. doi: 10.1186/s40409-015-0044-5. eCollection 2015.

BACKGROUND: Phospholipases A2 (PLA2s) are abundant components of snake venoms that have been extensively studied due to their pharmacological and pathophysiological effects on living organisms. This study aimed to assess the antitumor potential of BthTX-I, a basic myotoxic PLA2...

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Prinholato da Silva C, Costa TR, Paiva RM, et al. Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines. J Venom Anim Toxins Incl Trop Dis. 2015;21:44doi: 10.1186/s40409-015-0044-5.
Prinholato da Silva, C., Costa, T. R., Paiva, R. M., Cintra, A. C., Menaldo, D. L., Antunes, L. M., & Sampaio, S. V. (2015). Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines. The journal of venomous animals and toxins including tropical diseases, 2144. https://doi.org/10.1186/s40409-015-0044-5
Prinholato da Silva, Cássio, et al. "Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines." The journal of venomous animals and toxins including tropical diseases vol. 21 (2015): 44. doi: https://doi.org/10.1186/s40409-015-0044-5
Prinholato da Silva C, Costa TR, Paiva RM, Cintra AC, Menaldo DL, Antunes LM, Sampaio SV. Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines. J Venom Anim Toxins Incl Trop Dis. 2015 Nov 03;21:44. doi: 10.1186/s40409-015-0044-5. eCollection 2015. PMID: 26539212; PMCID: PMC4632473.
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