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Everolimus and plicamycin specifically target chemoresistant colorectal cancer cells of the CMS4 subtype.

Cell death & disease

Deng J, Tian AL, Pan H, Sauvat A, Leduc M, Liu P, Zhao L, Zhang S, Chen H, Taly V, Laurent-Puig P, Senovilla L, Li Y, Kroemer G, Kepp O.
PMID: 34675191
Cell Death Dis. 2021 Oct 21;12(11):978. doi: 10.1038/s41419-021-04270-x.

Colorectal cancers (CRC) can be classified into four consensus molecular subtypes (CMS), among which CMS1 has the best prognosis, contrasting with CMS4 that has the worst outcome. CMS4 CRC is notoriously resistant against therapeutic interventions, as demonstrated by preclinical...

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Deng J, Tian AL, Pan H, et al. Everolimus and plicamycin specifically target chemoresistant colorectal cancer cells of the CMS4 subtype. Cell Death Dis. 2021;12(11):978doi: 10.1038/s41419-021-04270-x.
Deng, J., Tian, A. L., Pan, H., Sauvat, A., Leduc, M., Liu, P., Zhao, L., Zhang, S., Chen, H., Taly, V., Laurent-Puig, P., Senovilla, L., Li, Y., Kroemer, G., & Kepp, O. (2021). Everolimus and plicamycin specifically target chemoresistant colorectal cancer cells of the CMS4 subtype. Cell death & disease, 12(11), 978. https://doi.org/10.1038/s41419-021-04270-x
Deng, Jiayin, et al. "Everolimus and plicamycin specifically target chemoresistant colorectal cancer cells of the CMS4 subtype." Cell death & disease vol. 12,11 (2021): 978. doi: https://doi.org/10.1038/s41419-021-04270-x
Deng J, Tian AL, Pan H, Sauvat A, Leduc M, Liu P, Zhao L, Zhang S, Chen H, Taly V, Laurent-Puig P, Senovilla L, Li Y, Kroemer G, Kepp O. Everolimus and plicamycin specifically target chemoresistant colorectal cancer cells of the CMS4 subtype. Cell Death Dis. 2021 Oct 21;12(11):978. doi: 10.1038/s41419-021-04270-x. PMID: 34675191; PMCID: PMC8531384.
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Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network.

Evidence-based complementary and alternative medicine : eCAM

Xue M, Zhang S, Cai C, Yu X, Shan L, Liu X, Zhang W, Li H.
PMID: 23737823
Evid Based Complement Alternat Med. 2013;2013:256782. doi: 10.1155/2013/256782. Epub 2013 Apr 29.

As the major issue to limit the use of drugs, drug safety leads to the attrition or failure in clinical trials of drugs. Therefore, it would be more efficient to minimize therapeutic risks if it could be predicted before...

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Xue M, Zhang S, Cai C, et al. Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network. Evid Based Complement Alternat Med. 2013;2013:256782doi: 10.1155/2013/256782.
Xue, M., Zhang, S., Cai, C., Yu, X., Shan, L., Liu, X., Zhang, W., & Li, H. (2013). Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network. Evidence-based complementary and alternative medicine : eCAM, 2013256782. https://doi.org/10.1155/2013/256782
Xue, Mengzhu, et al. "Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 256782. doi: https://doi.org/10.1155/2013/256782
Xue M, Zhang S, Cai C, Yu X, Shan L, Liu X, Zhang W, Li H. Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network. Evid Based Complement Alternat Med. 2013;2013:256782. doi: 10.1155/2013/256782. Epub 2013 Apr 29. PMID: 23737823; PMCID: PMC3657406.
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Gastric cancer-derived exosomal miR-135b-5p impairs the function of Vγ9Vδ2 T cells by targeting specificity protein 1.

Cancer immunology, immunotherapy : CII

Li J, Sun L, Chen Y, Zhu J, Shen J, Wang J, Gu Y, Zhang G, Wang M, Shi T, Chen W.
PMID: 34159436
Cancer Immunol Immunother. 2021 Jun 22; doi: 10.1007/s00262-021-02991-8. Epub 2021 Jun 22.

Recent studies have shown that tumor-derived exosomes participate in the communication between tumor cells and their microenvironment and mediate malignant biological behaviors including immune escape. In this study, we found that gastric cancer (GC) cell-derived exosomes could be effectively...

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Li J, Sun L, Chen Y, et al. Gastric cancer-derived exosomal miR-135b-5p impairs the function of Vγ9Vδ2 T cells by targeting specificity protein 1. Cancer Immunol Immunother. 2021;doi: 10.1007/s00262-021-02991-8.
Li, J., Sun, L., Chen, Y., Zhu, J., Shen, J., Wang, J., Gu, Y., Zhang, G., Wang, M., Shi, T., & Chen, W. (2021). Gastric cancer-derived exosomal miR-135b-5p impairs the function of Vγ9Vδ2 T cells by targeting specificity protein 1. Cancer immunology, immunotherapy : CII, . https://doi.org/10.1007/s00262-021-02991-8
Li, Juntao, et al. "Gastric cancer-derived exosomal miR-135b-5p impairs the function of Vγ9Vδ2 T cells by targeting specificity protein 1." Cancer immunology, immunotherapy : CII vol. (2021). doi: https://doi.org/10.1007/s00262-021-02991-8
Li J, Sun L, Chen Y, Zhu J, Shen J, Wang J, Gu Y, Zhang G, Wang M, Shi T, Chen W. Gastric cancer-derived exosomal miR-135b-5p impairs the function of Vγ9Vδ2 T cells by targeting specificity protein 1. Cancer Immunol Immunother. 2021 Jun 22; doi: 10.1007/s00262-021-02991-8. Epub 2021 Jun 22. PMID: 34159436.
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Bacteria as a treasure house of secondary metabolites with anticancer potential.

Seminars in cancer biology

Mohan CD, Rangappa S, Nayak SC, Jadimurthy R, Wang L, Sethi G, Garg M, Rangappa KS.
PMID: 33979675
Semin Cancer Biol. 2021 May 09; doi: 10.1016/j.semcancer.2021.05.006. Epub 2021 May 09.

Cancer stands in the frontline among leading killers worldwide and the annual mortality rate is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of cancers and many of them have a small number...

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Mohan CD, Rangappa S, Nayak SC, et al. Bacteria as a treasure house of secondary metabolites with anticancer potential. Semin Cancer Biol. 2021;doi: 10.1016/j.semcancer.2021.05.006.
Mohan, C. D., Rangappa, S., Nayak, S. C., Jadimurthy, R., Wang, L., Sethi, G., Garg, M., & Rangappa, K. S. (2021). Bacteria as a treasure house of secondary metabolites with anticancer potential. Seminars in cancer biology, . https://doi.org/10.1016/j.semcancer.2021.05.006
Mohan, Chakrabhavi Dhananjaya, et al. "Bacteria as a treasure house of secondary metabolites with anticancer potential." Seminars in cancer biology vol. (2021). doi: https://doi.org/10.1016/j.semcancer.2021.05.006
Mohan CD, Rangappa S, Nayak SC, Jadimurthy R, Wang L, Sethi G, Garg M, Rangappa KS. Bacteria as a treasure house of secondary metabolites with anticancer potential. Semin Cancer Biol. 2021 May 09; doi: 10.1016/j.semcancer.2021.05.006. Epub 2021 May 09. PMID: 33979675.
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