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Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells.

Antimicrobial agents and chemotherapy

Azad MA, Finnin BA, Poudyal A, Davis K, Li J, Hill PA, Nation RL, Velkov T, Li J.
PMID: 23796937
Antimicrob Agents Chemother. 2013 Sep;57(9):4329-4335. doi: 10.1128/AAC.02587-12. Epub 2013 Jun 24.

The nephrotoxicity of polymyxins is a major dose-limiting factor for treatment of infections caused by multidrug-resistant Gram-negative pathogens. The mechanism(s) of polymyxin-induced nephrotoxicity is not clear. This study aimed to investigate polymyxin B-induced apoptosis in kidney proximal tubular cells....

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Azad MA, Finnin BA, Poudyal A, et al. Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells. Antimicrob Agents Chemother. 2013;57(9):4329-4335doi: 10.1128/AAC.02587-12.
Azad, M. A., Finnin, B. A., Poudyal, A., Davis, K., Li, J., Hill, P. A., Nation, R. L., Velkov, T., & Li, J. (2013). Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells. Antimicrobial agents and chemotherapy, 57(9), 4329-4335. https://doi.org/10.1128/AAC.02587-12
Azad, Mohammad A K, et al. "Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells." Antimicrobial agents and chemotherapy vol. 57,9 (2013): 4329-4335. doi: https://doi.org/10.1128/AAC.02587-12
Azad MA, Finnin BA, Poudyal A, Davis K, Li J, Hill PA, Nation RL, Velkov T, Li J. Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells. Antimicrob Agents Chemother. 2013 Sep;57(9):4329-4335. doi: 10.1128/AAC.02587-12. Epub 2013 Jun 24. PMID: 23796937; PMCID: PMC3754291.
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Comparative Genomics of Two ST 195 Carbapenem-Resistant Acinetobacter baumannii with Different Susceptibility to Polymyxin Revealed Underlying Resistance Mechanism.

Frontiers in microbiology

Lean SS, Yeo CC, Suhaili Z, Thong KL.
PMID: 26779129
Front Microbiol. 2016 Jan 05;6:1445. doi: 10.3389/fmicb.2015.01445. eCollection 2015.

Acinetobacter baumannii is a Gram-negative nosocomial pathogen of importance due to its uncanny ability to acquire resistance to most antimicrobials. These include carbapenems, which are the drugs of choice for treating A. baumannii infections, and polymyxins, the drugs of...

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Lean SS, Yeo CC, Suhaili Z, et al. Comparative Genomics of Two ST 195 Carbapenem-Resistant Acinetobacter baumannii with Different Susceptibility to Polymyxin Revealed Underlying Resistance Mechanism. Front Microbiol. 2016;6:1445doi: 10.3389/fmicb.2015.01445.
Lean, S. S., Yeo, C. C., Suhaili, Z., & Thong, K. L. (2015). Comparative Genomics of Two ST 195 Carbapenem-Resistant Acinetobacter baumannii with Different Susceptibility to Polymyxin Revealed Underlying Resistance Mechanism. Frontiers in microbiology, 61445. https://doi.org/10.3389/fmicb.2015.01445
Lean, Soo-Sum, et al. "Comparative Genomics of Two ST 195 Carbapenem-Resistant Acinetobacter baumannii with Different Susceptibility to Polymyxin Revealed Underlying Resistance Mechanism." Frontiers in microbiology vol. 6 (2015): 1445. doi: https://doi.org/10.3389/fmicb.2015.01445
Lean SS, Yeo CC, Suhaili Z, Thong KL. Comparative Genomics of Two ST 195 Carbapenem-Resistant Acinetobacter baumannii with Different Susceptibility to Polymyxin Revealed Underlying Resistance Mechanism. Front Microbiol. 2016 Jan 05;6:1445. doi: 10.3389/fmicb.2015.01445. eCollection 2015. PMID: 26779129; PMCID: PMC4700137.
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Colistin and Polymyxin B Minimal Inhibitory Concentrations Determined by Etest Found Unreliable for Gram-Negative Bacilli.

The Ochsner journal

Simar S, Sibley D, Ashcraft D, Pankey G.
PMID: 29026355
Ochsner J. 2017;17(3):239-242.

BACKGROUND: A reliable method of polymyxin B and E (colistin) susceptibility testing remains elusive. These drugs diffuse poorly into agar, creating potentially inaccurate Etest and disk diffusion results, and testing by these methods is not recommended. Broth microdilution is...

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Simar S, Sibley D, Ashcraft D, et al. Colistin and Polymyxin B Minimal Inhibitory Concentrations Determined by Etest Found Unreliable for Gram-Negative Bacilli. Ochsner J. 2017;17(3):239-242
Simar, S., Sibley, D., Ashcraft, D., & Pankey, G. (2017). Colistin and Polymyxin B Minimal Inhibitory Concentrations Determined by Etest Found Unreliable for Gram-Negative Bacilli. The Ochsner journal, 17(3), 239-242.
Simar, Shelby, et al. "Colistin and Polymyxin B Minimal Inhibitory Concentrations Determined by Etest Found Unreliable for Gram-Negative Bacilli." The Ochsner journal vol. 17,3 (2017): 239-242.
Simar S, Sibley D, Ashcraft D, Pankey G. Colistin and Polymyxin B Minimal Inhibitory Concentrations Determined by Etest Found Unreliable for Gram-Negative Bacilli. Ochsner J. 2017;17(3):239-242. PMID: 29026355; PMCID: PMC5625981.
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Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria.

Frontiers in microbiology

Olaitan AO, Morand S, Rolain JM.
PMID: 25505462
Front Microbiol. 2014 Nov 26;5:643. doi: 10.3389/fmicb.2014.00643. eCollection 2014.

Polymyxins are polycationic antimicrobial peptides that are currently the last-resort antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The reintroduction of polymyxins for antimicrobial therapy has been followed by an increase in reports of resistance among Gram-negative bacteria....

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Olaitan AO, Morand S, Rolain JM. Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Front Microbiol. 2014;5:643doi: 10.3389/fmicb.2014.00643.
Olaitan, A. O., Morand, S., & Rolain, J. M. (2014). Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Frontiers in microbiology, 5643. https://doi.org/10.3389/fmicb.2014.00643
Olaitan, Abiola O, et al. "Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria." Frontiers in microbiology vol. 5 (2014): 643. doi: https://doi.org/10.3389/fmicb.2014.00643
Olaitan AO, Morand S, Rolain JM. Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Front Microbiol. 2014 Nov 26;5:643. doi: 10.3389/fmicb.2014.00643. eCollection 2014. PMID: 25505462; PMCID: PMC4244539.
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Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Liassine N, Assouvie L, Descombes MC, Tendon VD, Kieffer N, Poirel L, Nordmann P.
PMID: 27544715
Int J Infect Dis. 2016 Oct;51:4-5. doi: 10.1016/j.ijid.2016.08.008. Epub 2016 Aug 17.

No abstract available.

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Liassine N, Assouvie L, Descombes MC, et al. Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland. Int J Infect Dis. 2016;51:4-5doi: 10.1016/j.ijid.2016.08.008.
Liassine, N., Assouvie, L., Descombes, M. C., Tendon, V. D., Kieffer, N., Poirel, L., & Nordmann, P. (2016). Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 514-5. https://doi.org/10.1016/j.ijid.2016.08.008
Liassine, Nadia, et al. "Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland." International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases vol. 51 (2016): 4-5. doi: https://doi.org/10.1016/j.ijid.2016.08.008
Liassine N, Assouvie L, Descombes MC, Tendon VD, Kieffer N, Poirel L, Nordmann P. Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland. Int J Infect Dis. 2016 Oct;51:4-5. doi: 10.1016/j.ijid.2016.08.008. Epub 2016 Aug 17. PMID: 27544715.
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Influence of polymyxins on the structural dynamics of Escherichia coli lipid membranes.

Talanta

Clausell A, Pujol M, Alsina MA, Cajal Y.
PMID: 18969045
Talanta. 2003 Jun 13;60(2):225-34. doi: 10.1016/S0039-9140(03)00078-X.

Polymyxins are a family of nonribosomic cationic peptide antibiotics highly effective against Gram-negative bacteria. Two members of this family, Polymyxins B and E (PxB, PxE), form molecular vesicle-vesicle contacts and promote a selective exchange of phospholipids at very low...

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Clausell A, Pujol M, Alsina MA, et al. Influence of polymyxins on the structural dynamics of Escherichia coli lipid membranes. Talanta. 2003;60(2):225-34doi: 10.1016/S0039-9140(03)00078-X.
Clausell, A., Pujol, M., Alsina, M. A., & Cajal, Y. (2003). Influence of polymyxins on the structural dynamics of Escherichia coli lipid membranes. Talanta, 60(2), 225-34. https://doi.org/10.1016/S0039-9140(03)00078-X
Clausell, A, et al. "Influence of polymyxins on the structural dynamics of Escherichia coli lipid membranes." Talanta vol. 60,2 (2003): 225-34. doi: https://doi.org/10.1016/S0039-9140(03)00078-X
Clausell A, Pujol M, Alsina MA, Cajal Y. Influence of polymyxins on the structural dynamics of Escherichia coli lipid membranes. Talanta. 2003 Jun 13;60(2):225-34. doi: 10.1016/S0039-9140(03)00078-X. PMID: 18969045.
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Production of a potentially novel anti-microbial substance by Bacillus polymyxa.

World journal of microbiology & biotechnology

Rosado AS, Seldin L.
PMID: 24420193
World J Microbiol Biotechnol. 1993 Sep;9(5):521-8. doi: 10.1007/BF00386287.

A bacterial strain, SCE2, identified as Bacillus polymyxa, produced an anti-microbial substance active against yeasts, fungi and different genera of Gram-positive and-negative bacteria, in liquid medium and in plate assays. This substance appeared to be an antibiotic different from...

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Rosado AS, Seldin L. Production of a potentially novel anti-microbial substance by Bacillus polymyxa. World J Microbiol Biotechnol. 1993;9(5):521-8doi: 10.1007/BF00386287.
Rosado, A. S., & Seldin, L. (1993). Production of a potentially novel anti-microbial substance by Bacillus polymyxa. World journal of microbiology & biotechnology, 9(5), 521-8. https://doi.org/10.1007/BF00386287
Rosado, A S, and Seldin, L. "Production of a potentially novel anti-microbial substance by Bacillus polymyxa." World journal of microbiology & biotechnology vol. 9,5 (1993): 521-8. doi: https://doi.org/10.1007/BF00386287
Rosado AS, Seldin L. Production of a potentially novel anti-microbial substance by Bacillus polymyxa. World J Microbiol Biotechnol. 1993 Sep;9(5):521-8. doi: 10.1007/BF00386287. PMID: 24420193.
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A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia.

Antibiotics (Basel, Switzerland)

Biagi M, Butler D, Tan X, Qasmieh S, Wenzler E.
PMID: 30884839
Antibiotics (Basel). 2019 Mar 16;8(1). doi: 10.3390/antibiotics8010027.

Despite advancements in therapy, pneumonia remains the leading cause of death due to infectious diseases. Novel treatment strategies are desperately needed to optimize the antimicrobial therapy of patients suffering from this disease. One such strategy that has recently garnered...

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Biagi M, Butler D, Tan X, et al. A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia. Antibiotics (Basel). 2019;8(1)doi: 10.3390/antibiotics8010027.
Biagi, M., Butler, D., Tan, X., Qasmieh, S., & Wenzler, E. (2019). A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia. Antibiotics (Basel, Switzerland), 8(1), . https://doi.org/10.3390/antibiotics8010027
Biagi, Mark, et al. "A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia." Antibiotics (Basel, Switzerland) vol. 8,1 (2019). doi: https://doi.org/10.3390/antibiotics8010027
Biagi M, Butler D, Tan X, Qasmieh S, Wenzler E. A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia. Antibiotics (Basel). 2019 Mar 16;8(1). doi: 10.3390/antibiotics8010027. PMID: 30884839; PMCID: PMC6466860.
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Polymyxin Acute Kidney Injury: Dosing and Other Strategies to Reduce Toxicity.

Antibiotics (Basel, Switzerland)

Nation RL, Rigatto MHP, Falci DR, Zavascki AP.
PMID: 30875778
Antibiotics (Basel). 2019 Mar 14;8(1). doi: 10.3390/antibiotics8010024.

Polymyxins are valuable antimicrobials for the management of multidrug-resistant Gram-negative bacteria; however, nephrotoxicity associated with these drugs is a very common side effect that occurs during treatment. This article briefly reviews nephrotoxic mechanisms and risk factors for polymyxin-associated acute...

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Nation RL, Rigatto MHP, Falci DR, et al. Polymyxin Acute Kidney Injury: Dosing and Other Strategies to Reduce Toxicity. Antibiotics (Basel). 2019;8(1)doi: 10.3390/antibiotics8010024.
Nation, R. L., Rigatto, M. H. P., Falci, D. R., & Zavascki, A. P. (2019). Polymyxin Acute Kidney Injury: Dosing and Other Strategies to Reduce Toxicity. Antibiotics (Basel, Switzerland), 8(1), . https://doi.org/10.3390/antibiotics8010024
Nation, Roger L, et al. "Polymyxin Acute Kidney Injury: Dosing and Other Strategies to Reduce Toxicity." Antibiotics (Basel, Switzerland) vol. 8,1 (2019). doi: https://doi.org/10.3390/antibiotics8010024
Nation RL, Rigatto MHP, Falci DR, Zavascki AP. Polymyxin Acute Kidney Injury: Dosing and Other Strategies to Reduce Toxicity. Antibiotics (Basel). 2019 Mar 14;8(1). doi: 10.3390/antibiotics8010024. PMID: 30875778; PMCID: PMC6466603.
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Survey of quantitative antimicrobial consumption per production stage in farrow-to-finish pig farms in Spain.

Veterinary record open

Moreno MA.
PMID: 26392868
Vet Rec Open. 2014 Feb 13;1(1):e000002. doi: 10.1136/vropen-2013-000002. eCollection 2014.

OBJECTIVES: To characterise antimicrobial use (AMU) per production stage in terms of drugs, routes of application, indications, duration and exposed animals in farrow-to-finish pig farms in Spain.DESIGN: Survey using a questionnaire on AMU during the six months prior to...

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Moreno MA. Survey of quantitative antimicrobial consumption per production stage in farrow-to-finish pig farms in Spain. Vet Rec Open. 2014;1(1):e000002doi: 10.1136/vropen-2013-000002.
Moreno, M. A. (2014). Survey of quantitative antimicrobial consumption per production stage in farrow-to-finish pig farms in Spain. Veterinary record open, 1(1), e000002. https://doi.org/10.1136/vropen-2013-000002
Moreno, Miguel A. "Survey of quantitative antimicrobial consumption per production stage in farrow-to-finish pig farms in Spain." Veterinary record open vol. 1,1 (2014): e000002. doi: https://doi.org/10.1136/vropen-2013-000002
Moreno MA. Survey of quantitative antimicrobial consumption per production stage in farrow-to-finish pig farms in Spain. Vet Rec Open. 2014 Feb 13;1(1):e000002. doi: 10.1136/vropen-2013-000002. eCollection 2014. PMID: 26392868; PMCID: PMC4562438.
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Emergent Polymyxin Resistance: End of an Era?.

Open forum infectious diseases

Li Z, Cao Y, Yi L, Liu JH, Yang Q.
PMID: 31420655
Open Forum Infect Dis. 2019 Oct 01;6(10). doi: 10.1093/ofid/ofz368.

Until recently, the polymyxin antibiotics were sparingly used due to dose limiting toxicities. However, the lack of therapeutic alternatives for infections caused by highly resistant Gram-negative bacteria has led to the increased use of the polymyxins. Unfortunately, in the...

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Li Z, Cao Y, Yi L, et al. Emergent Polymyxin Resistance: End of an Era?. Open Forum Infect Dis. 2019;6(10)doi: 10.1093/ofid/ofz368.
Li, Z., Cao, Y., Yi, L., Liu, J. H., & Yang, Q. (2019). Emergent Polymyxin Resistance: End of an Era?. Open forum infectious diseases, 6(10), . https://doi.org/10.1093/ofid/ofz368
Li, Zekun, et al. "Emergent Polymyxin Resistance: End of an Era?." Open forum infectious diseases vol. 6,10 (2019). doi: https://doi.org/10.1093/ofid/ofz368
Li Z, Cao Y, Yi L, Liu JH, Yang Q. Emergent Polymyxin Resistance: End of an Era?. Open Forum Infect Dis. 2019 Oct 01;6(10). doi: 10.1093/ofid/ofz368. PMID: 31420655; PMCID: PMC6767968.
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Polymyxins: To Combine or Not to Combine?.

Antibiotics (Basel, Switzerland)

Perez F, El Chakhtoura NG, Yasmin M, Bonomo RA.
PMID: 30974813
Antibiotics (Basel). 2019 Apr 10;8(2). doi: 10.3390/antibiotics8020038.

Polymyxins have been a mainstay for the treatment of extensively drug resistant (XDR) Gram-negative bacteria for the past two decades. Many questions regarding the clinical use of polymyxins have been answered, but whether the administration of polymyxins in combination...

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Perez F, El Chakhtoura NG, Yasmin M, et al. Polymyxins: To Combine or Not to Combine?. Antibiotics (Basel). 2019;8(2)doi: 10.3390/antibiotics8020038.
Perez, F., El Chakhtoura, N. G., Yasmin, M., & Bonomo, R. A. (2019). Polymyxins: To Combine or Not to Combine?. Antibiotics (Basel, Switzerland), 8(2), . https://doi.org/10.3390/antibiotics8020038
Perez, Federico, et al. "Polymyxins: To Combine or Not to Combine?." Antibiotics (Basel, Switzerland) vol. 8,2 (2019). doi: https://doi.org/10.3390/antibiotics8020038
Perez F, El Chakhtoura NG, Yasmin M, Bonomo RA. Polymyxins: To Combine or Not to Combine?. Antibiotics (Basel). 2019 Apr 10;8(2). doi: 10.3390/antibiotics8020038. PMID: 30974813; PMCID: PMC6627991.
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Showing 1 to 12 of 176 entries