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Showing 1 to 12 of 85 entries
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Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose?.

Open access emergency medicine : OAEM

Kalsi SS, Wood DM, Waring WS, Dargan PI.
PMID: 27147854
Open Access Emerg Med. 2011 Oct 13;3:69-76. doi: 10.2147/OAEM.S24962. eCollection 2011.

Paracetamol (acetaminophen, N-acetyl-p-aminophenol, 4-hydroxyacetanilide) is the most common cause of acute liver failure in developed countries. There are a number of factors which potentially impact on the risk of an individual developing hepatotoxicity following an acute paracetamol overdose. These...

Essential Tremor.

Current treatment options in neurology

Lambert D, Waters CH.
PMID: 11096690
Curr Treat Options Neurol. 1999 Mar;1(1):6-13. doi: 10.1007/s11940-999-0027-3.

Multiple pharmacologic treatments have been studied, but propranolol and primidone have proven to be the most effective medications. It is unlikely that a patient will respond miraculously to another medication if his or her response to propranolol and primidone...

Topiramate Treatment of Essential Tremor in a Patient with Cognitive Deficits.

Case reports in neurology

Leblhuber F, Steiner K.
PMID: 20689627
Case Rep Neurol. 2010 Jan 15;2(1):1-4. doi: 10.1159/000264609.

This case report demonstrates a satisfying response to topiramate in a 79-year-old patient with disabling essential tremor in whom propranolol as well as primidone had to be discontinued due to severe side effects. After 28 months of topiramate treatment,...

Immunosuppressive microenvironment in neuroblastoma.

Frontiers in oncology

Pistoia V, Morandi F, Bianchi G, Pezzolo A, Prigione I, Raffaghello L.
PMID: 23805414
Front Oncol. 2013 Jun 26;3:167. doi: 10.3389/fonc.2013.00167. eCollection 2013.

According to the cancer immunoediting model, the interplay between tumor cells and the host immune system is crucial for the control of tumor growth. NB is a pediatric tumor that presents with metastatic disease at diagnosis in about 50%...

Treatment of Essential Tremor: Are there Issues We are Overlooking?.

Frontiers in neurology

Louis ED.
PMID: 22275907
Front Neurol. 2012 Jan 13;2:91. doi: 10.3389/fneur.2011.00091. eCollection 2011.

BACKGROUND: Essential tremor (ET) is one of the most common neurological diseases. Although a large number of medications have been tested, there are only two first-line medications, primidone and propranolol, which is a situation that has not changed in...

A Series of 211 Children with Probable Essential Tremor.

Movement disorders clinical practice

Ghosh D, Brar H, Lhamu U, Rothner AD, Erenberg G.
PMID: 30363473
Mov Disord Clin Pract. 2016 Jul 08;4(2):231-236. doi: 10.1002/mdc3.12385. eCollection 2017.

BACKGROUND: The objective of this study was to characterize the clinical features, course, and treatment of essential tremor (ET) in children.METHODS: A retrospective chart review was conducted over 25 years (1984-2011). Inclusion criteria were age

HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions.

Iranian journal of child neurology

Tonekaboni SH, Jafari N, Mansouri M, Jabbehdari S, Eftekhari R, Chavoshzadeh Z, Abdollah Gorji F, Mesdaghi M.
PMID: 28698724
Iran J Child Neurol. 2017;11(2):26-30.

OBJECTIVE: Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported.MATERIALS & METHODS: Fifteen patients with severe skin reactions following...

Homozygous mutation in .

Journal of medical genetics

Ravindran E, Gutierrez de Velazco C, Ghazanfar A, Kraemer N, Zaqout S, Waheed A, Hanif M, Mughal S, Prigione A, Li N, Fang X, Hu H, Kaindl AM.
PMID: 34059554
J Med Genet. 2021 May 31; doi: 10.1136/jmedgenet-2020-107518. Epub 2021 May 31.

BACKGROUND: Minichromosomal maintenance (MCM) complex components 2, 4, 5 and 6 have been linked to human disease with phenotypes including microcephaly and intellectual disability. The MCM complex has DNA helicase activity and is thereby important for the initiation and...

Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.

Epilepsy research

Gesche J, Hjalgrim H, Rubboli G, Beier CP.
PMID: 33421702
Epilepsy Res. 2021 Feb;170:106547. doi: 10.1016/j.eplepsyres.2020.106547. Epub 2021 Jan 04.

This study aimed at providing valid estimates for the risk of clinically relevant seizure aggravation by recommended anti-seizure medications in patients with Genetic Generalized Epilepsy (GGE). To this aim, treatment response, side effects and paradoxical reactions to anti-seizure treatment...

Assessment of Ethanol-Induced Toxicity on iPSC-Derived Human Neurons Using a Novel High-Throughput Mitochondrial Neuronal Health (MNH) Assay.

Frontiers in cell and developmental biology

Zink A, Conrad J, Telugu NS, Diecke S, Heinz A, Wanker E, Priller J, Prigione A.
PMID: 33224955
Front Cell Dev Biol. 2020 Nov 05;8:590540. doi: 10.3389/fcell.2020.590540. eCollection 2020.

Excessive ethanol exposure can cause mitochondrial and cellular toxicity. In order to discover potential counteracting interventions, it is essential to develop assays capable of capturing the consequences of ethanol exposure in human neurons, and particularly dopaminergic neurons that are...

Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease.

Clinical epidemiology

Pisa F, Reinold J, Lavikainen P, Koponen M, Taipale H, Tanskanen A, Tiihonen J, Hartikainen S, Tolppanen AM.
PMID: 33911901
Clin Epidemiol. 2021 Apr 22;13:295-307. doi: 10.2147/CLEP.S278306. eCollection 2021.

OBJECTIVE: To determine the risk of hip fracture in persons with Alzheimer´s disease (AD) who initiated antiepileptic drugs (AEDs).METHODS: In the Medication use and AD (MEDALZ) cohort of 70,719 Finnish community dwellers with clinically verified incident AD diagnosis in...

Photochemical oxidation of PPCPs using a combination of solar irradiation and free available chlorine.

The Science of the total environment

Cheng S, Zhang X, Song W, Pan Y, Lambropoulou D, Zhong Y, Du Y, Nie J, Yang X.
PMID: 31129545
Sci Total Environ. 2019 Sep 10;682:629-638. doi: 10.1016/j.scitotenv.2019.05.184. Epub 2019 May 17.

The degradation of pharmaceuticals and personal care products (PPCPs) by using solar photolysis in the presence of free available chlorine (FAC) was investigated in simulated drinking water. The combination of free available chlorine and sunlight irradiation dramatically accelerated the...

Showing 1 to 12 of 85 entries