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Showing 1 to 7 of 7 entries
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PLZF is a negative regulator of retinoic acid receptor transcriptional activity.

Nuclear receptor

Martin PJ, Delmotte MH, Formstecher P, Lefebvre P.
PMID: 14521715
Nucl Recept. 2003 Sep 06;1(1):6. doi: 10.1186/1478-1336-1-6.

BACKGROUND: Retinoic acid receptors (RARs) are ligand-regulated transcription factors controlling cellular proliferation and differentiation. Receptor-interacting proteins such as corepressors and coactivators play a crucial role in specifying the overall transcriptional activity of the receptor in response to ligand treatment....

Differential Proliferation Effects after Short-Term Cultivation of Mouse Spermatogonial Stem Cells on Different Feeder Layers.

Cell journal

Azizi H, Ghasemi Hamidabadi H, Skutella T.
PMID: 30825292
Cell J. 2019 Jul;21(2):186-193. doi: 10.22074/cellj.2019.5802. Epub 2019 Feb 20.

OBJECTIVE: Spermatogonial stem cells (SSCs) provide the cellular basis for sperm production transforming the male's genetic information to the next generation. We aimed to examine the effect of different feeder layer on proliferation of SSCs.MATERIALS AND METHODS: In this...

The promyelocytic leukemia zinc finger protein: two decades of molecular oncology.

Frontiers in oncology

Suliman BA, Xu D, Williams BR.
PMID: 22822476
Front Oncol. 2012 Jul 17;2:74. doi: 10.3389/fonc.2012.00074. eCollection 2012.

The promyelocytic leukemia zinc finger (PLZF) protein, also known as Zbtb16 or Zfp145, was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11;17)(q23;q21) resulted in a fusion with the RARA gene encoding retinoic...

The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56.

Hepatology communications

Hess LU, Martrus G, Ziegler AE, Langeneckert AE, Salzberger W, Goebels H, Sagebiel AF, Hagen SH, Poch T, Ravichandran G, Koch M, Schramm C, Oldhafer KJ, Fischer L, Tiegs G, Richert L, Bunders MJ, Lunemann S, Altfeld M.
PMID: 32140657
Hepatol Commun. 2020 Jan 06;4(3):409-424. doi: 10.1002/hep4.1463. eCollection 2020 Mar.

The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver-resident NK cells in mice. In human NK cells, the role of PLZF in liver...

Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys.

Frontiers in physiology

Dong L, Kristensen SG, Hildorf S, Gul M, Clasen-Linde E, Fedder J, Hoffmann ER, Cortes D, Thorup J, Andersen CY.
PMID: 31607938
Front Physiol. 2019 Sep 19;10:1155. doi: 10.3389/fphys.2019.01155. eCollection 2019.

BACKGROUND: Gonadotoxic treatment of malignant diseases as well as some non-malignant conditions such as cryptorchidism in young boys may result in infertility and failure to father children later in life. As a fertility preserving strategy, several centers collect testicular...

Gene and histomorphology alteration analysis in spermatogenesis arrest mouse model: a probable novel approach for infertility.

Central European journal of urology

Nabighadim A, Jafarnezhad-Ansariha F, Majidi Zolbin M, Daryabari SS, Fendereski K, Kajbafzadeh AM.
PMID: 33976924
Cent European J Urol. 2021;74(1):99-108. doi: 10.5173/ceju.2020.0175. Epub 2020 Dec 31.

INTRODUCTION: Approximately 15% of couples in the reproductive age are struggling with infertility which, in nearly half of them, is caused by male factors.MATERIAL AND METHODS: The present study comprised of two groups of sixteen C57BL/6 mice; each mouse...

Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases.

Epigenetics & chromatin

McConnell MJ, Durand L, Langley E, Coste-Sarguet L, Zelent A, Chomienne C, Kouzarides T, Licht JD, Guidez F.
PMID: 26405459
Epigenetics Chromatin. 2015 Sep 24;8:38. doi: 10.1186/s13072-015-0030-8. eCollection 2015.

BACKGROUND: The transcriptional repressor promyelocytic leukemia zinc finger protein (PLZF) is critical for the regulation of normal stem cells maintenance by establishing specific epigenetic landscape. We have previously shown that CBP/p300 acetyltransferase induces PLZF acetylation in order to increase...

Showing 1 to 7 of 7 entries