Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 1205 entries
Sorted by: Best Match Show Resources per page
Standardization of severe sepsis management: a survey of methodologies in academic and community settings

community settings

Nguyen HB.
GSID: iv_Faazpo14J
HB Nguyen, J Oh, RM Otero, K Burroughs… - The Journal of …, 2010 - Elsevier

Background: Evidence-based therapies for severe sepsis include early antibiotics, early goal-directed therapy, corticosteroids, recombinant human activated protein C, glucose control, and lung protective strategies. Objective: The objective of this study was to analyze methods, …

Disseminated intravascular coagulation.

Indian journal of anaesthesia

Venugopal A.
PMID: 25535423
Indian J Anaesth. 2014 Sep;58(5):603-8. doi: 10.4103/0019-5049.144666.

Disseminated intravascular coagulation (DIC) is a reflection of an underlying systemic disorder which affects the coagulation system, simultaneously resulting in pro-coagulant activation, fibrinolytic activation, and consumption coagulopathy and finally may result in organ dysfunction and death. Though septicaemia is...

Proteome analysis of testis from infertile protein C inhibitor-deficient mice reveals novel changes in serpin processing and prostaglandin metabolism.

Electrophoresis

Yang H, Wahlmüller FC, Uhrin P, Baumgartner R, Mitulovic G, Sarg B, Geiger M, Zellner M.
PMID: 26332751
Electrophoresis. 2015 Nov;36(21):2837-2840. doi: 10.1002/elps.201500218. Epub 2015 Oct 20.

Serine protease inhibitors (serpin) have therapeutic potential in a variety of pathogenic processes, ranging from thrombosis and altered immune response to liver cirrhosis. To investigate the physiological effects of protein C inhibitor (PCI, serpinA5), its gene was inactivated in...

NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferation.

Oncology letters

Lai XB, Nie YQ, Huang HL, Li YF, Cao CY, Yang H, Shen B, Feng ZQ.
PMID: 28454295
Oncol Lett. 2017 Mar;13(3):1587-1594. doi: 10.3892/ol.2017.5618. Epub 2017 Jan 18.

NIMA-related kinase 2 (Nek2) is often upregulated in human cancer and is important in regulating the cell cycle and gene expression, and maintaining centrosomal structure and function. The present study aimed to investigate the expression pattern, clinical significance, and...

Two mutations in surfactant protein C gene associated with neonatal respiratory distress.

Case reports in pediatrics

Tarocco A, Ballardini E, Contiero MR, Garani G, Fanaro S.
PMID: 26000190
Case Rep Pediatr. 2015;2015:591783. doi: 10.1155/2015/591783. Epub 2015 Apr 27.

Multiple mutations of surfactant genes causing surfactant dysfunction have been described. Surfactant protein C (SP-C) deficiency is associated with variable clinical manifestations ranging from neonatal respiratory distress syndrome to lethal lung disease. We present an extremely low birth weight...

Thrombin generation measured as thrombin-antithrombin complexes predicts clinical outcomes in patients with cirrhosis.

Hepatology research : the official journal of the Japan Society of Hepatology

Kalambokis GN, Oikonomou A, Baltayiannis G, Christou L, Kolaitis NI, Tsianos EV.
PMID: 25847196
Hepatol Res. 2016 Mar;46(3):E36-44. doi: 10.1111/hepr.12520. Epub 2015 May 22.

AIM: Hypercoagulability has been detected in patients with cirrhosis yet its clinical significance remains unclear. We investigated the association of hypercoagulability with clinical outcomes in patients with cirrhosis.METHODS: Thrombin-antithrombin (TAT) complexes as thrombin generation (TG) marker, D-dimer, antithrombin (AT),...

The coagulopathy of trauma.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

Maegele M.
PMID: 26815891
Eur J Trauma Emerg Surg. 2014 Apr;40(2):113-26. doi: 10.1007/s00068-014-0389-4. Epub 2014 Mar 18.

Trauma is a leading cause of death, with uncontrolled hemorrhage and exsanguination being the primary causes of preventable deaths during the first 24 h following trauma. Death usually occurs quickly, typically within the first 6 h after injury. One...

PO-14 - Tumour expression of coagulation proteases of the aPC pathway - a role in the pathogenesis of gynaecological cancers?.

Thrombosis research

Martin F, Long JC, O'Toole SA, O'Leary JJ, Abu Saadeh F, Gleeson N, Norris LA.
PMID: 27161702
Thromb Res. 2016 Apr;140:S181. doi: 10.1016/S0049-3848(16)30147-5. Epub 2016 Apr 08.

INTRODUCTION: The close relationship between coagulation, thrombosis and cancer has long been established. Gynaecological cancers, in particular ovarian cancers, carry a high risk of thrombosis but coagulation activation is also thought to play a role in tumorigenesis and metastasis....

PO-28 - Protein C levels are associated with mortality in patients with advanced cancer.

Thrombosis research

Wilts IT, Hutten BA, Meijers JC, Spek CA, Büller HR, Kamphuisen PW.
PMID: 27161716
Thromb Res. 2016 Apr;140:S186-7. doi: 10.1016/S0049-3848(16)30161-X. Epub 2016 Apr 08.

INTRODUCTION: In cancer, tumor progression and metastasis are promoted by prohemostatic activity. Protein C (PC) is involved in hemostasis, inflammation and signal transduction, and has a protective effect on the endothelial barrier. In mice, administration of activated PC reduced...

Natural Inhibitors and Lipids in Patients with Sickle Cell Disease.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Canatan D, Oğuz N, Özsancak A, Aslan İ, Bengü A, Gürman A, Sarıca B.
PMID: 27263501
Turk J Haematol. 2000 Sep 05;17(3):119-22.

Microvascular occlusion in sickle cell disease (SCD) is a multifactorial process. Disordered coagulation may play a role in the pathogenesis of vaso occlusive crisis (VOC). The aim of this study was to evaluate the patients and to investigate their...

Haemostatic Profile in Patients of Myeloproliferative Neoplasms-A Tertiary Care Centre Experience.

Journal of clinical and diagnostic research : JCDR

Parashar Y, Kushwaha R, Kumar A, Agarwal K, Singh US, Jain M, Verma SP, Tripathi AK.
PMID: 28050371
J Clin Diagn Res. 2016 Nov;10(11):EC01-EC04. doi: 10.7860/JCDR/2016/19985.8840. Epub 2016 Nov 01.

INTRODUCTION: Patients of MPN commonly present with abnormalities in laboratory coagulation tests that are consistent with hypercoagulable state. Some individuals with MPN exhibit a pattern of exclusive bleeding or thrombotic events; many others have both bleeding and thrombosis during...

Thrombophilia in East Asian countries: are there any genetic differences in these countries?.

Thrombosis journal

Miyata T, Maruyama K, Banno F, Neki R.
PMID: 27766051
Thromb J. 2016 Oct 04;14:25. doi: 10.1186/s12959-016-0109-x. eCollection 2016.

In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have greatly increased. The PS-K196E mutation is often identified in the...

Showing 1 to 12 of 1205 entries