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Showing 1 to 12 of 304 entries
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Upstream solutions for price-gouging on critical generic medicines.

Journal of pharmaceutical policy and practice

Houston AR, Beall RF, Attaran A.
PMID: 27141308
J Pharm Policy Pract. 2016 May 02;9:15. doi: 10.1186/s40545-016-0064-8. eCollection 2016.

Exorbitant price increases for critical off-patent medicines have received considerable media attention in recent months, leading to an investigation by the U.S. Senate. However, much of this attention has focused upon the companies that initiated the price increases, all...

Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana.

Journal of parasitology research

Yeboah DF, Afoakwah R, Nwaefuna EK, Verner O, Boampong JN.
PMID: 27042341
J Parasitol Res. 2016;2016:9231946. doi: 10.1155/2016/9231946. Epub 2016 Mar 06.

The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efficacy of SP. This study sets out to evaluate the...

Adherence to treatment guidelines for uncomplicated malaria at two public health facilities in Nigeria; Implications for the 'test and treat' policy of malaria case management.

Journal of pharmaceutical policy and practice

Ezenduka CC, Okonta MJ, Esimone CO.
PMID: 25838917
J Pharm Policy Pract. 2014 Nov 14;7(1):15. doi: 10.1186/2052-3211-7-15. eCollection 2014.

OBJECTIVES: Adherence to treatment guidelines for uncomplicated malaria is critical to the success of malaria case management. Poor adherence has implications for increased malaria burden, in view of the risk of widespread parasite resistance and treatment failures. This study...

Efficacy of Pyrimethamine/Sulfadoxine versus Chloroquine for the Treatment of Uncomplicated Falciparum Malaria in Children Aged Under 5 Years.

Iranian journal of parasitology

Zheng W, Jiang H, Xiong Z, Jiang Z, Chen H.
PMID: 23682255
Iran J Parasitol. 2013 Jan;8(1):1-17.

The children aged under 5 years from vast African areas badly suffer from falciparum malaria and many of them die of this disease. Therapeutic efficacy of anti-malaria drugs, especially pyrimethamine-sulfadoxine (PS) and chloroquine (CQ) to falciparum malaria is frequently...

Intravitreal clindamycin in the treatment of unresponsive zone one toxoplasmic chorioretinitis: a case report.

Iranian Red Crescent medical journal

Hosseini SM, Abrishami M, Mehdi Zadeh M.
PMID: 25763208
Iran Red Crescent Med J. 2014 Nov 17;16(11):e15428. doi: 10.5812/ircmj.15428. eCollection 2014 Nov.

INTRODUCTION: The current study aimed to report a case of toxoplasma chorioretinitis resistant to standard treatments that dramatically responded to intravitreal clindamycin injection.CASE PRESENTATION: A 23-year-old woman with the diagnosis of ocular toxoplasmosis in the left eye was initially...

Cotrimoxazole in the treatment of acute uncomplicated falciparum malaria in nigerian children : a controlled clinical trial.

Clinical drug investigation

Fehintola FA, Adedeji AA, Tambo E, Fateye BB, Happi TC, Sowunmi A.
PMID: 17516701
Clin Drug Investig. 2004;24(3):149-55. doi: 10.2165/00044011-200424030-00003.

OBJECTIVES: To evaluate the efficacy of cotrimoxazole in the treatment of Plasmodium falciparum malaria and to compare the efficacy of cotrimoxazole with that of pyrimethamine-sulfadoxine, a second-line antimalarial drug, in an area of high malaria transmission.PATIENTS AND METHODS: Children...

Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice.

Iranian journal of allergy, asthma, and immunology

Keshavarzi M, Hassan ZM.
PMID: 17301350
Iran J Allergy Asthma Immunol. 2003 Mar;2(1):7-12. doi: 02.01/ijaai.712.

In this study, a crude leishmanial antigen, was prepared by son icating Leishmania major promastigotes used to induce immunity in BALB/c mice against cutaneous leishmaniasis. Correlation between the route of antigen injection and the efficacy of induced protection was...

Effect of immunomodulator pyrimethamine and cimetidine on immunosuppression induced by burn blister fluid.

Iranian journal of allergy, asthma, and immunology

Gharegozloo B, Hassan ZM, K Ardestani S, Tavassoli N.
PMID: 17301405
Iran J Allergy Asthma Immunol. 2004 Sep;3(3):139-43. doi: 03.03/ijaai.139143.

Despite recent advances in burn wound management, sepsis remains the main cause of death in patients resuscitated after major thermal injury. Increased susceptibility to infections has been related to severe suppression of the immune system.The aim of this study...

Folate and cobalamin metabolism in Plasmodium falciparum.

Parasitology today (Personal ed.)

Krungkrai J, Webster HK, Yuthavong Y.
PMID: 15463278
Parasitol Today. 1990 Dec;6(12):388-91. doi: 10.1016/0169-4758(90)90148-w.

During the past several years, Jerapan Krungkrai, H. Kyle Webster and Yongyuth Yuthavong have characterized the metabolic pathway of folate biosynthesis and folate-dependent reactions, including the cobalamin-dependent activity of methionine synthase, in P. falciparum grown in vitro. In this...

Travellers' malaria.

Parasitology today (Personal ed.)

Steffen R, Behrens RH.
PMID: 15463573
Parasitol Today. 1992 Feb;8(2):61-6. doi: 10.1016/0169-4758(92)90091-f.

The risk of malaria poses travellers and their advisers with difficult problems as drug resistance spreads worldwide. Protection against infection rests on travellers' knowledge of the risk of malaria, on their avoidance of malaria vectors and on their compliant...

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum.

PLoS clinical trials

Dunyo S, Ord R, Hallett R, Jawara M, Walraven G, Mesa E, Coleman R, Sowe M, Alexander N, Targett GA, Pinder M, Sutherland CJ.
PMID: 16871319
PLoS Clin Trials. 2006 Jul 21;1(3):e14. doi: 10.1371/journal.pctr.0010014.

OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence of parasites carrying alleles...

Clinical trials of chemotherapy for falciparum malaria.

Expert opinion on investigational drugs

Winstanley P, Olliaro P.
PMID: 15991958
Expert Opin Investig Drugs. 1998 Feb;7(2):261-71. doi: 10.1517/13543784.7.2.261.

Plasmodium falciparum remains one of the World's most prevalent and devastating pathogens. Mainly for economic reasons, the parasite's ability to develop resistance to drugs has not been matched by the rate at which new compounds are developed. Even so,...

Showing 1 to 12 of 304 entries