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Showing 1 to 12 of 41 entries
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5-Oxoprolinase (l-Pyroglutamate Hydrolase) in Higher Plants: Partial Purification and Characterization of the Wheat Germ Enzyme.

Plant physiology

Mazelis M, Creveling RK.
PMID: 16660609
Plant Physiol. 1978 Nov;62(5):798-801. doi: 10.1104/pp.62.5.798.

5-Oxoprolinase has been found to be widely distributed in higher plants. This enzyme catalyzes the ATP-dependent hydrolysis of 5-oxo-l-proline (l-pyrollidone carboxylate, l-pyroglutamate) to glutamate. The enzyme has been purified almost 60 fold from wheat germ (Triticum aestivum L). This...

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Mazelis M, Creveling RK. 5-Oxoprolinase (l-Pyroglutamate Hydrolase) in Higher Plants: Partial Purification and Characterization of the Wheat Germ Enzyme. Plant Physiol. 1978;62(5):798-801doi: 10.1104/pp.62.5.798.
Mazelis, M., & Creveling, R. K. (1978). 5-Oxoprolinase (l-Pyroglutamate Hydrolase) in Higher Plants: Partial Purification and Characterization of the Wheat Germ Enzyme. Plant physiology, 62(5), 798-801. https://doi.org/10.1104/pp.62.5.798
Mazelis, M, and Creveling, R K. "5-Oxoprolinase (l-Pyroglutamate Hydrolase) in Higher Plants: Partial Purification and Characterization of the Wheat Germ Enzyme." Plant physiology vol. 62,5 (1978): 798-801. doi: https://doi.org/10.1104/pp.62.5.798
Mazelis M, Creveling RK. 5-Oxoprolinase (l-Pyroglutamate Hydrolase) in Higher Plants: Partial Purification and Characterization of the Wheat Germ Enzyme. Plant Physiol. 1978 Nov;62(5):798-801. doi: 10.1104/pp.62.5.798. PMID: 16660609; PMCID: PMC1092224.
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Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma.

Cancer biology & medicine

Ye DJ, Zhang JM.
PMID: 23691439
Cancer Biol Med. 2013 Mar;10(1):10-5. doi: 10.7497/j.issn.2095-3941.2013.01.002.

Thymidine phosphorylase (TP) is a key enzyme that contributes to the composition and decomposition of pyrimidine nucleotides. TP seems homologous to platelet-derived endothelial cell growth factor, and its effects on inducing vascularization and anti-apoptosis are closely related to growth...

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Ye DJ, Zhang JM. Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma. Cancer Biol Med. 2013;10(1):10-5doi: 10.7497/j.issn.2095-3941.2013.01.002.
Ye, D. J., & Zhang, J. M. (2013). Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma. Cancer biology & medicine, 10(1), 10-5. https://doi.org/10.7497/j.issn.2095-3941.2013.01.002
Ye, Dian-Jun, and Zhang, Ji-Min. "Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma." Cancer biology & medicine vol. 10,1 (2013): 10-5. doi: https://doi.org/10.7497/j.issn.2095-3941.2013.01.002
Ye DJ, Zhang JM. Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma. Cancer Biol Med. 2013 Mar;10(1):10-5. doi: 10.7497/j.issn.2095-3941.2013.01.002. PMID: 23691439; PMCID: PMC3643685.
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Changes of purine and pyrimidine nucleotide biosynthesis during shoot initiation from epicotyl explants of white spruce (Picea glauca).

Plant science : an international journal of experimental plant biology

Stasolla C, Loukanina N, Ashihara H, Yeung EC, Thorpe TA.
PMID: 22980203
Plant Sci. 2006 Sep;171(3):345-54. doi: 10.1016/j.plantsci.2006.04.004. Epub 2006 May 15.

Nucleotide metabolism was investigated during white spruce organogenesis by following the metabolic fate of (14)C-labeled adenine, adenosine and inosine, as purine precursors, and orotic acid, uridine, and uracil, as pyrimidine intermediates. Key enzymes of purine and pyrimidine metabolism were...

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Stasolla C, Loukanina N, Ashihara H, et al. Changes of purine and pyrimidine nucleotide biosynthesis during shoot initiation from epicotyl explants of white spruce (Picea glauca). Plant Sci. 2006;171(3):345-54doi: 10.1016/j.plantsci.2006.04.004.
Stasolla, C., Loukanina, N., Ashihara, H., Yeung, E. C., & Thorpe, T. A. (2006). Changes of purine and pyrimidine nucleotide biosynthesis during shoot initiation from epicotyl explants of white spruce (Picea glauca). Plant science : an international journal of experimental plant biology, 171(3), 345-54. https://doi.org/10.1016/j.plantsci.2006.04.004
Stasolla, Claudio, et al. "Changes of purine and pyrimidine nucleotide biosynthesis during shoot initiation from epicotyl explants of white spruce (Picea glauca)." Plant science : an international journal of experimental plant biology vol. 171,3 (2006): 345-54. doi: https://doi.org/10.1016/j.plantsci.2006.04.004
Stasolla C, Loukanina N, Ashihara H, Yeung EC, Thorpe TA. Changes of purine and pyrimidine nucleotide biosynthesis during shoot initiation from epicotyl explants of white spruce (Picea glauca). Plant Sci. 2006 Sep;171(3):345-54. doi: 10.1016/j.plantsci.2006.04.004. Epub 2006 May 15. PMID: 22980203.
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Photooxidation of nucleic acids on metal oxides: physico-chemical and astrobiological perspectives.

The journal of physical chemistry. C, Nanomaterials and interfaces

Shkrob IA, Marin TM, Adhikary A, Sevilla MD.
PMID: 21399705
J Phys Chem C Nanomater Interfaces. 2011 Feb 07;115(8):3393-3403. doi: 10.1021/jp110682c.

Photocatalytic oxidation of nucleic acid components on aqueous metal oxides (TiO(2), α-FeOOH, and α-Fe(2)O(3)) has been studied. The oxidation of purine nucleotides results in the formation of the purine radical cations and sugar-phosphate radicals, whereas the oxidation of pyrimidine...

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Shkrob IA, Marin TM, Adhikary A, et al. Photooxidation of nucleic acids on metal oxides: physico-chemical and astrobiological perspectives. J Phys Chem C Nanomater Interfaces. 2011;115(8):3393-3403doi: 10.1021/jp110682c.
Shkrob, I. A., Marin, T. M., Adhikary, A., & Sevilla, M. D. (2011). Photooxidation of nucleic acids on metal oxides: physico-chemical and astrobiological perspectives. The journal of physical chemistry. C, Nanomaterials and interfaces, 115(8), 3393-3403. https://doi.org/10.1021/jp110682c
Shkrob, Ilya A, et al. "Photooxidation of nucleic acids on metal oxides: physico-chemical and astrobiological perspectives." The journal of physical chemistry. C, Nanomaterials and interfaces vol. 115,8 (2011): 3393-3403. doi: https://doi.org/10.1021/jp110682c
Shkrob IA, Marin TM, Adhikary A, Sevilla MD. Photooxidation of nucleic acids on metal oxides: physico-chemical and astrobiological perspectives. J Phys Chem C Nanomater Interfaces. 2011 Feb 07;115(8):3393-3403. doi: 10.1021/jp110682c. PMID: 21399705; PMCID: PMC3049938.
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SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides.

Journal of biochemistry

Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT.
PMID: 34244779
J Biochem. 2021 Jul 09; doi: 10.1093/jb/mvab077. Epub 2021 Jul 09.

Since the discovery of nucleotides over 100 years ago, extensive studies have revealed the importance of nucleotides for homeostasis, health, and disease. However, there remains no established method to investigate quantitively and accurately intact nucleotide incorporation into RNA and...

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Ikeda Y, Hirayama A, Kofuji S, et al. SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. J Biochem. 2021;doi: 10.1093/jb/mvab077.
Ikeda, Y., Hirayama, A., Kofuji, S., Hirota, Y., Kamata, R., Osaka, N., Fujii, Y., Sasaki, M., Ikeda, S., Smith, E. P., Bachoo, R., Soga, T., & Sasaki, A. T. (2021). SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. Journal of biochemistry, . https://doi.org/10.1093/jb/mvab077
Ikeda, Yoshiki, et al. "SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides." Journal of biochemistry vol. (2021). doi: https://doi.org/10.1093/jb/mvab077
Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT. SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. J Biochem. 2021 Jul 09; doi: 10.1093/jb/mvab077. Epub 2021 Jul 09. PMID: 34244779.
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Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma.

The Prostate

Kim S, Li L, Zhang J, Jiang C, Lü J.
PMID: 34662447
Prostate. 2022 Jan;82(1):154-166. doi: 10.1002/pros.24256. Epub 2021 Oct 18.

BACKGROUND: Metabolic reprograming is now a recognized hallmark of cancer. The prostate-specific phosphatase and tensin homolog deleted on chromosome 10 (Pten) gene-conditional knockout (KO) mouse carcinogenesis model is highly desirable for studying prostate cancer biology and prevention due to...

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Kim S, Li L, Zhang J, et al. Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma. Prostate. 2021;82(1):154-166doi: 10.1002/pros.24256.
Kim, S., Li, L., Zhang, J., Jiang, C., & Lü, J. (2022). Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma. The Prostate, 82(1), 154-166. https://doi.org/10.1002/pros.24256
Kim, Sangyub, et al. "Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma." The Prostate vol. 82,1 (2022): 154-166. doi: https://doi.org/10.1002/pros.24256
Kim S, Li L, Zhang J, Jiang C, Lü J. Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma. Prostate. 2022 Jan;82(1):154-166. doi: 10.1002/pros.24256. Epub 2021 Oct 18. PMID: 34662447.
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Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance of .

Frontiers in plant science

Jung S, Koo KM, Ryu J, Baek I, Kwon SJ, Kim JB, Ahn JW.
PMID: 34512699
Front Plant Sci. 2021 Aug 26;12:719846. doi: 10.3389/fpls.2021.719846. eCollection 2021.

The enzyme phosphoribosyl pyrophosphate synthase (PRPS) catalyzes the conversion of ribose 5-phosphate into phosphoribosyl diphosphate; the latter is a precursor of purine and pyrimidine nucleotides. Here, we investigated the function of PRPS from the single-celled green alga

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Jung S, Koo KM, Ryu J, et al. Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance of . Front Plant Sci. 2021;12:719846doi: 10.3389/fpls.2021.719846.
Jung, S., Koo, K. M., Ryu, J., Baek, I., Kwon, S. J., Kim, J. B., & Ahn, J. W. (2021). Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance of . Frontiers in plant science, 12719846. https://doi.org/10.3389/fpls.2021.719846
Jung, Sera, et al. "Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance of ." Frontiers in plant science vol. 12 (2021): 719846. doi: https://doi.org/10.3389/fpls.2021.719846
Jung S, Koo KM, Ryu J, Baek I, Kwon SJ, Kim JB, Ahn JW. Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance of . Front Plant Sci. 2021 Aug 26;12:719846. doi: 10.3389/fpls.2021.719846. eCollection 2021. PMID: 34512699; PMCID: PMC8427504.
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Interplay Between Capsule Expression and Uracil Metabolism in .

Frontiers in microbiology

Carvalho SM, Kloosterman TG, Manzoor I, Caldas J, Vinga S, Martinussen J, Saraiva LM, Kuipers OP, Neves AR.
PMID: 29599757
Front Microbiol. 2018 Mar 06;9:321. doi: 10.3389/fmicb.2018.00321. eCollection 2018.

Pyrimidine nucleotides play an important role in the biosynthesis of activated nucleotide sugars (NDP-sugars). NDP-sugars are the precursors of structural polysaccharides in bacteria, including capsule, which is a major virulence factor of the human pathogen

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Carvalho SM, Kloosterman TG, Manzoor I, et al. Interplay Between Capsule Expression and Uracil Metabolism in . Front Microbiol. 2018;9:321doi: 10.3389/fmicb.2018.00321.
Carvalho, S. M., Kloosterman, T. G., Manzoor, I., Caldas, J., Vinga, S., Martinussen, J., Saraiva, L. M., Kuipers, O. P., & Neves, A. R. (2018). Interplay Between Capsule Expression and Uracil Metabolism in . Frontiers in microbiology, 9321. https://doi.org/10.3389/fmicb.2018.00321
Carvalho, Sandra M, et al. "Interplay Between Capsule Expression and Uracil Metabolism in ." Frontiers in microbiology vol. 9 (2018): 321. doi: https://doi.org/10.3389/fmicb.2018.00321
Carvalho SM, Kloosterman TG, Manzoor I, Caldas J, Vinga S, Martinussen J, Saraiva LM, Kuipers OP, Neves AR. Interplay Between Capsule Expression and Uracil Metabolism in . Front Microbiol. 2018 Mar 06;9:321. doi: 10.3389/fmicb.2018.00321. eCollection 2018. PMID: 29599757; PMCID: PMC5863508.
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Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y.

MedChemComm

Toti KS, Jain S, Ciancetta A, Balasubramanian R, Chakraborty S, Surujdin R, Shi ZD, Jacobson KA.
PMID: 29423136
Medchemcomm. 2017 Oct 01;8(10):1897-1908. doi: 10.1039/C7MD00397H. Epub 2017 Sep 06.

Both agonists and antagonists of the UDP-activated P2Y

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Toti KS, Jain S, Ciancetta A, et al. Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y. Medchemcomm. 2017;8(10):1897-1908doi: 10.1039/C7MD00397H.
Toti, K. S., Jain, S., Ciancetta, A., Balasubramanian, R., Chakraborty, S., Surujdin, R., Shi, Z. D., & Jacobson, K. A. (2017). Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y. MedChemComm, 8(10), 1897-1908. https://doi.org/10.1039/C7MD00397H
Toti, Kiran S, et al. "Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y." MedChemComm vol. 8,10 (2017): 1897-1908. doi: https://doi.org/10.1039/C7MD00397H
Toti KS, Jain S, Ciancetta A, Balasubramanian R, Chakraborty S, Surujdin R, Shi ZD, Jacobson KA. Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y. Medchemcomm. 2017 Oct 01;8(10):1897-1908. doi: 10.1039/C7MD00397H. Epub 2017 Sep 06. PMID: 29423136; PMCID: PMC5798474.
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A Novel [.

Journal of analytical & bioanalytical techniques

Jin F, Bhowmik SK, Putluri V, Gu F, Gohlke J, Von Rundstedt FC, Dasgupta S, Krishnapuram R, O'Malley BW, Sreekumar A, Putluri N.
PMID: 27158554
J Anal Bioanal Tech. 2015 Oct;6(5). doi: 10.4172/2155-9872.1000267. Epub 2015 Aug 30.

The growth of cancer cells relies more on increased proliferation and autonomy compared to non-malignant cells. The rate of de novo nucleotide biosynthesis correlates with cell proliferation rates. In part, glutamine is needed to sustain high rates of cellular...

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Jin F, Bhowmik SK, Putluri V, et al. A Novel [. J Anal Bioanal Tech. 2015;6(5)doi: 10.4172/2155-9872.1000267.
Jin, F., Bhowmik, S. K., Putluri, V., Gu, F., Gohlke, J., Von Rundstedt, F. C., Dasgupta, S., Krishnapuram, R., O'Malley, B. W., Sreekumar, A., & Putluri, N. (2015). A Novel [. Journal of analytical & bioanalytical techniques, 6(5), . https://doi.org/10.4172/2155-9872.1000267
Jin, Feng, et al. "A Novel [." Journal of analytical & bioanalytical techniques vol. 6,5 (2015). doi: https://doi.org/10.4172/2155-9872.1000267
Jin F, Bhowmik SK, Putluri V, Gu F, Gohlke J, Von Rundstedt FC, Dasgupta S, Krishnapuram R, O'Malley BW, Sreekumar A, Putluri N. A Novel [. J Anal Bioanal Tech. 2015 Oct;6(5). doi: 10.4172/2155-9872.1000267. Epub 2015 Aug 30. PMID: 27158554; PMCID: PMC4857768.
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Pea leaf glutamine synthetase: regulatory properties.

Plant physiology

O'neal TD, Joy KW.
PMID: 16659228
Plant Physiol. 1975 Jun;55(6):968-74. doi: 10.1104/pp.55.6.968.

Of a variety of purine and pyrimidine nucleotides tested, only ADP and 5'AMP significantly inhibited the Mg(2+)-dependent activity of pea leaf glutamine synthetase. They were less effective inhibitors where Mn(2+) replaced Mg(2+). They were competitive inhibitors with respect to...

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O'neal TD, Joy KW. Pea leaf glutamine synthetase: regulatory properties. Plant Physiol. 1975;55(6):968-74doi: 10.1104/pp.55.6.968.
O'neal, T. D., & Joy, K. W. (1975). Pea leaf glutamine synthetase: regulatory properties. Plant physiology, 55(6), 968-74. https://doi.org/10.1104/pp.55.6.968
O'neal, T D, and Joy, K W. "Pea leaf glutamine synthetase: regulatory properties." Plant physiology vol. 55,6 (1975): 968-74. doi: https://doi.org/10.1104/pp.55.6.968
O'neal TD, Joy KW. Pea leaf glutamine synthetase: regulatory properties. Plant Physiol. 1975 Jun;55(6):968-74. doi: 10.1104/pp.55.6.968. PMID: 16659228; PMCID: PMC541748.
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Aspartate Carbamyltransferase : Site of End-Product Inhibition of the Orotate Pathway in Intact Cells of Cucurbita pepo.

Plant physiology

Lovatt CJ, Cheng AH.
PMID: 16663656
Plant Physiol. 1984 Jul;75(3):511-5. doi: 10.1104/pp.75.3.511.

Lovatt et al. (1979 Plant Physiol 64: 562-569) have previously demonstrated that end-product inhibition functions as a mechanism regulating the activity of the orotic acid pathway in intact cells of roots excised from 2-day-old squash plants (Cucurbita pepo L....

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Lovatt CJ, Cheng AH. Aspartate Carbamyltransferase : Site of End-Product Inhibition of the Orotate Pathway in Intact Cells of Cucurbita pepo. Plant Physiol. 1984;75(3):511-5doi: 10.1104/pp.75.3.511.
Lovatt, C. J., & Cheng, A. H. (1984). Aspartate Carbamyltransferase : Site of End-Product Inhibition of the Orotate Pathway in Intact Cells of Cucurbita pepo. Plant physiology, 75(3), 511-5. https://doi.org/10.1104/pp.75.3.511
Lovatt, C J, and Cheng, A H. "Aspartate Carbamyltransferase : Site of End-Product Inhibition of the Orotate Pathway in Intact Cells of Cucurbita pepo." Plant physiology vol. 75,3 (1984): 511-5. doi: https://doi.org/10.1104/pp.75.3.511
Lovatt CJ, Cheng AH. Aspartate Carbamyltransferase : Site of End-Product Inhibition of the Orotate Pathway in Intact Cells of Cucurbita pepo. Plant Physiol. 1984 Jul;75(3):511-5. doi: 10.1104/pp.75.3.511. PMID: 16663656; PMCID: PMC1066945.
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Showing 1 to 12 of 41 entries