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Showing 1 to 12 of 791 entries
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Synthesis of Quinolines via a Metal-Catalyzed Dehydrogenative N-Heterocyclization.

Chemical record (New York, N.Y.)

Chelucci G, Porcheddu A.
PMID: 27524555
Chem Rec. 2017 Feb;17(2):200-216. doi: 10.1002/tcr.201600083. Epub 2016 Aug 15.

Efficient ruthenium-, rhodium-, palladium-, copper- and iridium-catalysed methodologies have been recently developed for the synthesis of quinolines by the reaction of 2-aminobenzyl alcohols with carbonyl compounds (aldehydes and ketones) or the related alcohols. The reaction is assumed to proceed...

Renal Abscess Caused by Salmonella Typhi.

Journal of laboratory physicians

Kaur A, Sarma S, Kumar N, Sengupta S.
PMID: 26417164
J Lab Physicians. 2015 Jul-Dec;7(2):121-3. doi: 10.4103/0974-2727.163132.

Salmonella typhi is a true pathogen, which is capable of causing both intestinal and extraintestinal infections. Unusual presentations of Salmonella should always be kept in mind as this organism can cause disease in almost any organ of the body....

Bacterial Etiology and Antibiotic Resistance Profile of Community-Acquired Urinary Tract Infections in a Cameroonian City.

International journal of microbiology

Nzalie RN, Gonsu HK, Koulla-Shiro S.
PMID: 27667998
Int J Microbiol. 2016;2016:3240268. doi: 10.1155/2016/3240268. Epub 2016 Sep 07.

Introduction. Community-acquired urinary tract infections (CAUTIs) are usually treated empirically. Geographical variations in etiologic agents and their antibiotic sensitivity patterns are common. Knowledge of antibiotic resistance trends is important for improving evidence-based recommendations for empirical treatment of UTIs. Our...

Dual role of Rh(III) catalyst enables regioselective halogenation of (electron-rich) heterocycles.

Journal of the American Chemical Society

Schröder N, Lied F, Glorius F.
PMID: 25590585
J Am Chem Soc. 2015 Feb 04;137(4):1448-51. doi: 10.1021/jacs.5b00283. Epub 2015 Jan 27.

The Rh(III)-catalyzed selective bromination and iodination of electron-rich heterocycles is reported. Kinetic investigations show that Rh plays a dual role in the bromination, catalyzing the directed halogenation and preventing the inherent halogenation of these substrates. As a result, this...

Phosphine-Initiated General-Base-Catalyzed Quinolone Synthesis.

Asian journal of organic chemistry

Khong S, Kwon O.
PMID: 26207200
Asian J Org Chem. 2014 Apr;3(4):453-457. doi: 10.1002/ajoc.201402039.

Phosphinocatalysis provides a new approach toward 3-substituted-4-quinolones. A simple procedure, which uses Ph

Synthesis of Aryl Ketoamides via Aryne Insertion into Imides.

Organic letters

Wright AC, Haley CK, Lapointe G, Stoltz BM.
PMID: 27266278
Org Lett. 2016 Jun 17;18(12):2793-5. doi: 10.1021/acs.orglett.6b00994. Epub 2016 Jun 07.

An insertion of arenes into both imides and anhydrides via reactive aryne intermediates is presented. The reaction is performed under exceptionally mild conditions, and the corresponding ketoamide products are amenable to derivatization to deliver a variety of synthetically useful...

Divergent Synthesis of Quinolone Natural Products from .

European journal of organic chemistry

Geddis SM, Carro L, Hodgkinson JT, Spring DR.
PMID: 28111524
European J Org Chem. 2016 Dec;2016(35):5799-5802. doi: 10.1002/ejoc.201601195. Epub 2016 Nov 15.

Two divergent synthetic routes are reported offering access to four quinolone natural products from

Palladium-Catalyzed Annulation of Internal Alkynes: Direct Access to π-Conjugated Ullazines.

Organic letters

Wan D, Li X, Jiang R, Feng B, Lan J, Wang R, You J.
PMID: 27227659
Org Lett. 2016 Jun 17;18(12):2876-9. doi: 10.1021/acs.orglett.6b01182. Epub 2016 May 26.

A palladium-catalyzed cyclization reaction of 1-(2,6-dibromophenyl)-1H-pyrroles with alkynes has been developed to construct various π-conjugated indolizino[6,5,4,3-ija]quinolones (ullazines) with a reactive functional group tolerance. As illustrative examples, three new ullazine-based sensitizers are synthesized, and the performance of these dyes is...

Non-steroidal anti-inflammatory drugs and antibiotics prescription trends at a central west bank hospital.

Sultan Qaboos University medical journal

Tayem YI, Qubaja MM, Shraim RK, Taha OB, Abu Shkheidem IA, Ibrahim MA.
PMID: 24273668
Sultan Qaboos Univ Med J. 2013 Nov;13(4):567-73. doi: 10.12816/0003317. Epub 2013 Nov 08.

OBJECTIVES: We aimed to reliably describe the pattern of outpatient prescription of non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics (ATBs) at a central hospital in the West Bank, Palestine.METHODS: This was a retrospective, cross-sectional study investigating a cohort of 2,208...

Empyema necessitans complicating pleural effusion associated with proteus species infection: a diagnostic dilemma.

Case reports in pediatrics

Yauba MS, Ahmed H, Imoudu IA, Yusuf MO, Makarfi HU.
PMID: 25893125
Case Rep Pediatr. 2015;2015:108174. doi: 10.1155/2015/108174. Epub 2015 Mar 29.

Background. Empyema necessitans, a rare complication of pleural effusion, could result in significant morbidity and mortality in children. It is characterized by the dissection of pus through the soft tissues and the skin of the chest wall. Mycobacterium tuberculosis...

Clinical importance and epidemiology of quinolone resistance.

Infection & chemotherapy

Kim ES, Hooper DC.
PMID: 25566402
Infect Chemother. 2014 Dec;46(4):226-38. doi: 10.3947/ic.2014.46.4.226. Epub 2014 Dec 29.

The quinolone class of antimicrobial agents is one of most widely used classes of antimicrobial agents in outpatient and inpatient treatment. However, quinolone resistance in gram-positive and gram-negative bacteria has emerged and increased globally. This resistance limits the usefulness...

Combination Therapy of Sophoraflavanone B against MRSA: In Vitro Synergy Testing.

Evidence-based complementary and alternative medicine : eCAM

Mun SH, Kang OH, Joung DK, Kim SB, Seo YS, Choi JG, Lee YS, Cha SW, Ahn YS, Han SH, Kwon DY.
PMID: 24319486
Evid Based Complement Alternat Med. 2013;2013:823794. doi: 10.1155/2013/823794. Epub 2013 Nov 10.

Sophoraflavanone B (SPF-B), a known prenylated flavonoid, was isolated from the roots of Desmodium caudatum. The aim of this study was to determine the antimicrobial synergism of SPF-B combined with antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). MRSA, a multidrug-resistant...

Showing 1 to 12 of 791 entries