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Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.

Proceedings of the National Academy of Sciences of the United States of America

Mony VK, Drangowska-Way A, Albert R, Harrison E, Ghaddar A, Horak MK, Ke W, O'Rourke EJ.
PMID: 34607947
Proc Natl Acad Sci U S A. 2021 Oct 12;118(41). doi: 10.1073/pnas.2104832118.

Plasticity in multicellular organisms involves signaling pathways converting contexts-either natural environmental challenges or laboratory perturbations-into context-specific changes in gene expression. Congruently, the interactions between the signaling molecules and transcription factors (TF) regulating these responses are also context specific. However,...

Cite
Mony VK, Drangowska-Way A, Albert R, et al. Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions. Proc Natl Acad Sci U S A. 2021;118(41)doi: 10.1073/pnas.2104832118.
Mony, V. K., Drangowska-Way, A., Albert, R., Harrison, E., Ghaddar, A., Horak, M. K., Ke, W., & O'Rourke, E. J. (2021). Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions. Proceedings of the National Academy of Sciences of the United States of America, 118(41), . https://doi.org/10.1073/pnas.2104832118
Mony, Vinod K, et al. "Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions." Proceedings of the National Academy of Sciences of the United States of America vol. 118,41 (2021). doi: https://doi.org/10.1073/pnas.2104832118
Mony VK, Drangowska-Way A, Albert R, Harrison E, Ghaddar A, Horak MK, Ke W, O'Rourke EJ. Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41). doi: 10.1073/pnas.2104832118. PMID: 34607947; PMCID: PMC8521664.
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Genes in human obesity loci are causal obesity genes in C. elegans.

PLoS genetics

Ke W, Reed JN, Yang C, Higgason N, Rayyan L, Wählby C, Carpenter AE, Civelek M, O'Rourke EJ.
PMID: 34492009
PLoS Genet. 2021 Sep 07;17(9):e1009736. doi: 10.1371/journal.pgen.1009736. eCollection 2021 Sep.

Obesity and its associated metabolic syndrome are a leading cause of morbidity and mortality. Given the disease's heavy burden on patients and the healthcare system, there has been increased interest in identifying pharmacological targets for the treatment and prevention...

Cite
Ke W, Reed JN, Yang C, et al. Genes in human obesity loci are causal obesity genes in C. elegans. PLoS Genet. 2021;17(9):e1009736doi: 10.1371/journal.pgen.1009736.
Ke, W., Reed, J. N., Yang, C., Higgason, N., Rayyan, L., Wählby, C., Carpenter, A. E., Civelek, M., & O'Rourke, E. J. (2021). Genes in human obesity loci are causal obesity genes in C. elegans. PLoS genetics, 17(9), e1009736. https://doi.org/10.1371/journal.pgen.1009736
Ke, Wenfan, et al. "Genes in human obesity loci are causal obesity genes in C. elegans." PLoS genetics vol. 17,9 (2021): e1009736. doi: https://doi.org/10.1371/journal.pgen.1009736
Ke W, Reed JN, Yang C, Higgason N, Rayyan L, Wählby C, Carpenter AE, Civelek M, O'Rourke EJ. Genes in human obesity loci are causal obesity genes in C. elegans. PLoS Genet. 2021 Sep 07;17(9):e1009736. doi: 10.1371/journal.pgen.1009736. eCollection 2021 Sep. PMID: 34492009; PMCID: PMC8462697.
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