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Heme oxygenase induction attenuates TNF-α-induced hypertension in pregnant rodents.

Frontiers in pharmacology

George EM, Stout JM, Stec DE, Granger JP.
PMID: 26347650
Front Pharmacol. 2015 Aug 17;6:165. doi: 10.3389/fphar.2015.00165. eCollection 2015.

Pre-eclampsia is a hypertensive disorder of pregnancy initiated by placental insufficiency and chronic ischemia. In response, several pathways activated in the placenta are responsible for the maternal syndrome, including increased production of the anti-angiogenic protein, sFlt-1, and inflammatory cytokines,...

Growth factor purification and delivery systems (PADS) for therapeutic angiogenesis.

Vascular cell

George EM, Liu H, Robinson GG, Mahdi F, Perkins E, Bidwell GL.
PMID: 25653833
Vasc Cell. 2015 Jan 24;7(1):1. doi: 10.1186/s13221-014-0026-3. eCollection 2015.

BACKGROUND: Therapeutic angiogenesis with vascular endothelial growth factor (VEGF), delivered either via recombinant protein infusion or via gene therapy, has shown promise in preclinical models of various diseases including myocardial infarction, renovascular disease, preeclampsia, and neurodegenerative disorders. However, dosing,...

Maternally sequestered therapeutic polypeptides - a new approach for the management of preeclampsia.

Frontiers in pharmacology

Bidwell GL, George EM.
PMID: 25249978
Front Pharmacol. 2014 Sep 05;5:201. doi: 10.3389/fphar.2014.00201. eCollection 2014.

The last several decades have seen intensive research into the molecular mechanisms underlying the symptoms of preeclampsia. While the underlying cause of preeclampsia is believed to be defective placental development and resulting placental ischemia, it is only recently that...

Showing 1 to 3 of 3 entries