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Showing 1 to 9 of 9 entries
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Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Journal of clinical and translational research

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H.
PMID: 26722668
J Clin Transl Res. 2015;1(2):100-106. doi: 10.18053/jctres.201502.004. Epub 2015 Sep 30.

BACKGROUND: Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mechanistic studies in mice and humans have implicated formation of a reactive metabolite, mitochondrial dysfunction and oxidant stress as critical events in the pathophysiology...

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Xie Y, Woolbright BL, Kos M, et al. Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. J Clin Transl Res. 2015;1(2):100-106doi: 10.18053/jctres.201502.004.
Xie, Y., Woolbright, B. L., Kos, M., McGill, M. R., Dorko, K., Kumer, S. C., Schmitt, T. M., & Jaeschke, H. (2015). Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. Journal of clinical and translational research, 1(2), 100-106. https://doi.org/10.18053/jctres.201502.004
Xie, Yuchao, et al. "Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity." Journal of clinical and translational research vol. 1,2 (2015): 100-106. doi: https://doi.org/10.18053/jctres.201502.004
Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H. Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. J Clin Transl Res. 2015;1(2):100-106. doi: 10.18053/jctres.201502.004. Epub 2015 Sep 30. PMID: 26722668; PMCID: PMC4694640.
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Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.

Journal of clinical and translational research

Ramachandran A, Jaeschke H.
PMID: 28670625
J Clin Transl Res. 2017 Feb;3:157-169. doi: 10.18053/jctres.03.2017S1.002. Epub 2017 Feb 12.

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and mechanisms of liver injury induced by APAP overdose have been the focus of extensive investigation. Studies in the mouse model, which closely...

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Ramachandran A, Jaeschke H. Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology. J Clin Transl Res. 2017;3:157-169doi: 10.18053/jctres.03.2017S1.002.
Ramachandran, A., & Jaeschke, H. (2017). Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology. Journal of clinical and translational research, 3157-169. https://doi.org/10.18053/jctres.03.2017S1.002
Ramachandran, Anup, and Jaeschke, Hartmut. "Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology." Journal of clinical and translational research vol. 3 (2017): 157-169. doi: https://doi.org/10.18053/jctres.03.2017S1.002
Ramachandran A, Jaeschke H. Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology. J Clin Transl Res. 2017 Feb;3:157-169. doi: 10.18053/jctres.03.2017S1.002. Epub 2017 Feb 12. PMID: 28670625; PMCID: PMC5489132.
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Oxidative Stress and Acute Hepatic Injury.

Current opinion in toxicology

Ramachandran A, Jaeschke H.
PMID: 29399645
Curr Opin Toxicol. 2018 Feb;7:17-21. doi: 10.1016/j.cotox.2017.10.011.

Reactive oxygen species have long been implicated in the pathophysiology of acute liver injury. However, the translation of these findings to the clinic and the development of therapeutic agents have been slow mainly due to the poor mechanistic understanding...

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Ramachandran A, Jaeschke H. Oxidative Stress and Acute Hepatic Injury. Curr Opin Toxicol. 2018;7:17-21doi: 10.1016/j.cotox.2017.10.011.
Ramachandran, A., & Jaeschke, H. (2018). Oxidative Stress and Acute Hepatic Injury. Current opinion in toxicology, 717-21. https://doi.org/10.1016/j.cotox.2017.10.011
Ramachandran, Anup, and Jaeschke, Hartmut. "Oxidative Stress and Acute Hepatic Injury." Current opinion in toxicology vol. 7 (2018): 17-21. doi: https://doi.org/10.1016/j.cotox.2017.10.011
Ramachandran A, Jaeschke H. Oxidative Stress and Acute Hepatic Injury. Curr Opin Toxicol. 2018 Feb;7:17-21. doi: 10.1016/j.cotox.2017.10.011. PMID: 29399645; PMCID: PMC5793911.
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The impact of sterile inflammation in acute liver injury.

Journal of clinical and translational research

Woolbright BL, Jaeschke H.
PMID: 28670626
J Clin Transl Res. 2017 Feb;3:170-188. doi: 10.18053/jctres.03.2017S1.003. Epub 2017 Feb 12.

BACKGROUND: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver...

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Woolbright BL, Jaeschke H. The impact of sterile inflammation in acute liver injury. J Clin Transl Res. 2017;3:170-188doi: 10.18053/jctres.03.2017S1.003.
Woolbright, B. L., & Jaeschke, H. (2017). The impact of sterile inflammation in acute liver injury. Journal of clinical and translational research, 3170-188. https://doi.org/10.18053/jctres.03.2017S1.003
Woolbright, Benjamin L, and Jaeschke, Hartmut. "The impact of sterile inflammation in acute liver injury." Journal of clinical and translational research vol. 3 (2017): 170-188. doi: https://doi.org/10.18053/jctres.03.2017S1.003
Woolbright BL, Jaeschke H. The impact of sterile inflammation in acute liver injury. J Clin Transl Res. 2017 Feb;3:170-188. doi: 10.18053/jctres.03.2017S1.003. Epub 2017 Feb 12. PMID: 28670626; PMCID: PMC5488807.
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MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.

Journal of clinical medicine

McGill MR, Jaeschke H.
PMID: 26167291
J Clin Med. 2015 May 20;4(5):1063-78. doi: 10.3390/jcm4051063. eCollection 2015 May.

Drug-induced liver injury (DILI) is major problem for both the drug industry and for clinicians. There are two basic categories of DILI: intrinsic and idiosyncratic. The former is the chief cause of acute liver failure in several developed countries,...

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McGill MR, Jaeschke H. MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury. J Clin Med. 2015;4(5):1063-78doi: 10.3390/jcm4051063.
McGill, M. R., & Jaeschke, H. (2015). MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury. Journal of clinical medicine, 4(5), 1063-78. https://doi.org/10.3390/jcm4051063
McGill, Mitchell R, and Jaeschke, Hartmut. "MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury." Journal of clinical medicine vol. 4,5 (2015): 1063-78. doi: https://doi.org/10.3390/jcm4051063
McGill MR, Jaeschke H. MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury. J Clin Med. 2015 May 20;4(5):1063-78. doi: 10.3390/jcm4051063. eCollection 2015 May. PMID: 26167291; PMCID: PMC4470217.
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Alcoholic Hepatitis: Lost in Translation.

Journal of clinical and translational hepatology

Woolbright BL, Jaeschke H.
PMID: 29577035
J Clin Transl Hepatol. 2018 Mar 28;6(1):89-96. doi: 10.14218/JCTH.2017.00054. Epub 2017 Dec 17.

Alcoholic hepatitis is the most severe and acute form of alcoholic liver disease. The mortality rate associated with alcoholic hepatitis is high, largely due to the lack of suitable pharmacological interventions. While there has been substantial research in the...

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Woolbright BL, Jaeschke H. Alcoholic Hepatitis: Lost in Translation. J Clin Transl Hepatol. 2017;6(1):89-96doi: 10.14218/JCTH.2017.00054.
Woolbright, B. L., & Jaeschke, H. (2018). Alcoholic Hepatitis: Lost in Translation. Journal of clinical and translational hepatology, 6(1), 89-96. https://doi.org/10.14218/JCTH.2017.00054
Woolbright, Benjamin L, and Jaeschke, Hartmut. "Alcoholic Hepatitis: Lost in Translation." Journal of clinical and translational hepatology vol. 6,1 (2018): 89-96. doi: https://doi.org/10.14218/JCTH.2017.00054
Woolbright BL, Jaeschke H. Alcoholic Hepatitis: Lost in Translation. J Clin Transl Hepatol. 2018 Mar 28;6(1):89-96. doi: 10.14218/JCTH.2017.00054. Epub 2017 Dec 17. PMID: 29577035; PMCID: PMC5863004.
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Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease.

Journal of clinical and translational research

van Golen RF, Stevens KM, Colarusso P, Jaeschke H, Heger M.
PMID: 26925465
J Clin Transl Res. 2015;1(2):107-115. doi: 10.18053/jctres.201502.001. Epub 2015 Sep 13.

BACKGROUND: Platelets and P-selectin (CD62P) play an unequivocal role in the pathology of hepatic ischemia/reperfusion (I/R) injury. Inhibition or knock-out of P-selectin or immunodepletion of platelets results in amelioration of post-ischemic inflammation, reduced hepatocellular damage, and improved survival. However,...

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van Golen RF, Stevens KM, Colarusso P, et al. Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease. J Clin Transl Res. 2015;1(2):107-115doi: 10.18053/jctres.201502.001.
van Golen, R. F., Stevens, K. M., Colarusso, P., Jaeschke, H., & Heger, M. (2015). Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease. Journal of clinical and translational research, 1(2), 107-115. https://doi.org/10.18053/jctres.201502.001
van Golen, Rowan F, et al. "Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease." Journal of clinical and translational research vol. 1,2 (2015): 107-115. doi: https://doi.org/10.18053/jctres.201502.001
van Golen RF, Stevens KM, Colarusso P, Jaeschke H, Heger M. Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease. J Clin Transl Res. 2015;1(2):107-115. doi: 10.18053/jctres.201502.001. Epub 2015 Sep 13. PMID: 26925465; PMCID: PMC4767188.
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Is Keratin-18 only a Marker of Cell Death in Acute-On-Chronic Liver Failure?.

Journal of laboratory and precision medicine

Woolbright BL, Jaeschke H.
PMID: 29928749
J Lab Precis Med. 2018 Mar;3. doi: 10.21037/jlpm.2018.03.07. Epub 2018 Mar 20.

No abstract available.

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Woolbright BL, Jaeschke H. Is Keratin-18 only a Marker of Cell Death in Acute-On-Chronic Liver Failure?. J Lab Precis Med. 2018;3doi: 10.21037/jlpm.2018.03.07.
Woolbright, B. L., & Jaeschke, H. (2018). Is Keratin-18 only a Marker of Cell Death in Acute-On-Chronic Liver Failure?. Journal of laboratory and precision medicine, 3. https://doi.org/10.21037/jlpm.2018.03.07
Woolbright, Benjamin L, and Jaeschke, Hartmut. "Is Keratin-18 only a Marker of Cell Death in Acute-On-Chronic Liver Failure?." Journal of laboratory and precision medicine vol. 3 (2018). doi: https://doi.org/10.21037/jlpm.2018.03.07
Woolbright BL, Jaeschke H. Is Keratin-18 only a Marker of Cell Death in Acute-On-Chronic Liver Failure?. J Lab Precis Med. 2018 Mar;3. doi: 10.21037/jlpm.2018.03.07. Epub 2018 Mar 20. PMID: 29928749; PMCID: PMC6005660.
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Acetaminophen-induced Liver Injury: from Animal Models to Humans.

Journal of clinical and translational hepatology

Jaeschke H, Xie Y, McGill MR.
PMID: 26355817
J Clin Transl Hepatol. 2014 Sep;2(3):153-61. doi: 10.14218/JCTH.2014.00014. Epub 2014 Sep 15.

Drug-induced liver injury is an important clinical problem and a challenge for drug development. Whereas progress in understanding rare and unpredictable (idiosyncratic) drug hepatotoxicity is severely hampered by the lack of relevant animal models, enormous insight has been gained...

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Jaeschke H, Xie Y, McGill MR. Acetaminophen-induced Liver Injury: from Animal Models to Humans. J Clin Transl Hepatol. 2014;2(3):153-61doi: 10.14218/JCTH.2014.00014.
Jaeschke, H., Xie, Y., & McGill, M. R. (2014). Acetaminophen-induced Liver Injury: from Animal Models to Humans. Journal of clinical and translational hepatology, 2(3), 153-61. https://doi.org/10.14218/JCTH.2014.00014
Jaeschke, Hartmut, et al. "Acetaminophen-induced Liver Injury: from Animal Models to Humans." Journal of clinical and translational hepatology vol. 2,3 (2014): 153-61. doi: https://doi.org/10.14218/JCTH.2014.00014
Jaeschke H, Xie Y, McGill MR. Acetaminophen-induced Liver Injury: from Animal Models to Humans. J Clin Transl Hepatol. 2014 Sep;2(3):153-61. doi: 10.14218/JCTH.2014.00014. Epub 2014 Sep 15. PMID: 26355817; PMCID: PMC4521247.
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Showing 1 to 9 of 9 entries