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Showing 1 to 8 of 8 entries
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Gene-based and pathway-based genome-wide association study of alcohol dependence.

Shanghai archives of psychiatry

Zuo L, Zhang CK, Sayward FG, Cheung KH, Wang K, Krystal JH, Zhao H, Luo X.
PMID: 26120261
Shanghai Arch Psychiatry. 2015 Apr 25;27(2):111-8. doi: 10.11919/j.issn.1002-0829.215031.

BACKGROUND: The organization of risk genes within signaling pathways may provide clues about the converging neurobiological effects of risk genes for alcohol dependence.AIM: Identify risk genes and risk gene pathways for alcohol dependence.METHODS: We conducted a pathway-based genome-wide association...

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.

Behavior genetics

van den Berg SM, de Moor MH, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abdellaoui A, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Smith GD, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Mbarek H, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Nivard MG, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, Penninx BW, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Martin NG, Boomsma DI.
PMID: 26362575
Behav Genet. 2016 Mar;46(2):170-82. doi: 10.1007/s10519-015-9735-5. Epub 2015 Sep 11.

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively...

Sex difference of autosomal alleles in populations of European and African descent.

Genes & genomics

Zuo L, Wang T, Lin X, Wang J, Tan Y, Wang X, Yu X, Luo X.
PMID: 26702338
Genes Genomics. 2015 Dec 01;37(12):1007-1016. doi: 10.1007/s13258-015-0332-z. Epub 2015 Sep 03.

In the present study, we aimed to report the individual sex-different genetic markers across autosomes in European- and African-origin populations. A total of 8,400 females and 8,081 males in 19 independent cohorts were genotyped across genomes using Illumina or...

Multi-Polygenic Analysis of Nicotine Dependence in Individuals of European Ancestry.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Risner VA, Benca-Bachman CE, Bertin L, Smith AK, Kaprio J, McGeary JE, Chesler E, Knopik VS, Friedman NP, Palmer RHC.
PMID: 34008017
Nicotine Tob Res. 2021 Nov 05;23(12):2102-2109. doi: 10.1093/ntr/ntab105.

INTRODUCTION: Heritability estimates of nicotine dependence (ND) range from 40% to 70%, but discovery GWAS of ND are underpowered and have limited predictive utility. In this work, we leverage genetically correlated traits and diseases to increase the accuracy of...

Hidden heritability due to heterogeneity across seven populations.

Nature human behaviour

Tropf FC, Lee SH, Verweij RM, Stulp G, van der Most PJ, de Vlaming R, Bakshi A, Briley DA, Rahal C, Hellpap R, Iliadou AN, Esko T, Metspalu A, Medland SE, Martin NG, Barban N, Snieder H, Robinson MR, Mills MC.
PMID: 29051922
Nat Hum Behav. 2017 Oct;1(10):757-765. doi: 10.1038/s41562-017-0195-1. Epub 2017 Sep 11.

Meta-analyses of genome-wide association studies (GWAS), which dominate genetic discovery are based on data from diverse historical time periods and populations. Genetic scores derived from GWAS explain only a fraction of the heritability estimates obtained from whole-genome studies on...

Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data.

Journal of data mining in genomics & proteomics

Lubke G, Laurin C, Walters R, Eriksson N, Hysi P, Spector T, Montgomery G, Martin N, Medland S, Boomsma D.
PMID: 24404405
J Data Mining Genomics Proteomics. 2013 Oct 20;4. doi: 10.4172/2153-0602.1000143.

Typically, genome-wide association studies consist of regressing the phenotype on each SNP separately using an additive genetic model. Although statistical models for recessive, dominant, SNP-SNP, or SNP-environment interactions exist, the testing burden makes an evaluation of all possible effects...

Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.

Science advances

Simcoe M, Valdes A, Liu F, Furlotte NA, Evans DM, Hemani G, Ring SM, Smith GD, Duffy DL, Zhu G, Gordon SD, Medland SE, Vuckovic D, Girotto G, Sala C, Catamo E, Concas MP, Brumat M, Gasparini P, Toniolo D, Cocca M, Robino A, Yazar S, Hewitt A, Wu W, Kraft P, Hammond CJ, Shi Y, Chen Y, Zeng C, Klaver CCW, Uitterlinden AG, Ikram MA, Hamer MA, van Duijn CM, Nijsten T, Han J, Mackey DA, Martin NG, Cheng CY, Hinds DA, Spector TD, Kayser M, Hysi PG.
PMID: 33692100
Sci Adv. 2021 Mar 10;7(11). doi: 10.1126/sciadv.abd1239. Print 2021 Mar.

Human eye color is highly heritable, but its genetic architecture is not yet fully understood. We report the results of the largest genome-wide association study for eye color to date, involving up to 192,986 European participants from 10 populations....

Multi-Polygenic Analysis of Nicotine Dependence in Individuals of European Ancestry.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Risner VA, Benca-Bachman CE, Bertin L, Smith AK, Kaprio J, McGeary JE, Chesler E, Knopik VS, Friedman NP, Palmer RHC.
PMID: 34008017
Nicotine Tob Res. 2021 Nov 05;23(12):2102-2109. doi: 10.1093/ntr/ntab105.

INTRODUCTION: Heritability estimates of nicotine dependence (ND) range from 40% to 70%, but discovery GWAS of ND are underpowered and have limited predictive utility. In this work, we leverage genetically correlated traits and diseases to increase the accuracy of...

Showing 1 to 8 of 8 entries