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Hidden heritability due to heterogeneity across seven populations.

Nature human behaviour

Tropf FC, Lee SH, Verweij RM, Stulp G, van der Most PJ, de Vlaming R, Bakshi A, Briley DA, Rahal C, Hellpap R, Iliadou AN, Esko T, Metspalu A, Medland SE, Martin NG, Barban N, Snieder H, Robinson MR, Mills MC.
PMID: 29051922
Nat Hum Behav. 2017 Oct;1(10):757-765. doi: 10.1038/s41562-017-0195-1. Epub 2017 Sep 11.

Meta-analyses of genome-wide association studies (GWAS), which dominate genetic discovery are based on data from diverse historical time periods and populations. Genetic scores derived from GWAS explain only a fraction of the heritability estimates obtained from whole-genome studies on...

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Tropf FC, Lee SH, Verweij RM, et al. Hidden heritability due to heterogeneity across seven populations. Nat Hum Behav. 2017;1(10):757-765doi: 10.1038/s41562-017-0195-1.
Tropf, F. C., Lee, S. H., Verweij, R. M., Stulp, G., van der Most, P. J., de Vlaming, R., Bakshi, A., Briley, D. A., Rahal, C., Hellpap, R., Iliadou, A. N., Esko, T., Metspalu, A., Medland, S. E., Martin, N. G., Barban, N., Snieder, H., Robinson, M. R., & Mills, M. C. (2017). Hidden heritability due to heterogeneity across seven populations. Nature human behaviour, 1(10), 757-765. https://doi.org/10.1038/s41562-017-0195-1
Tropf, Felix C, et al. "Hidden heritability due to heterogeneity across seven populations." Nature human behaviour vol. 1,10 (2017): 757-765. doi: https://doi.org/10.1038/s41562-017-0195-1
Tropf FC, Lee SH, Verweij RM, Stulp G, van der Most PJ, de Vlaming R, Bakshi A, Briley DA, Rahal C, Hellpap R, Iliadou AN, Esko T, Metspalu A, Medland SE, Martin NG, Barban N, Snieder H, Robinson MR, Mills MC. Hidden heritability due to heterogeneity across seven populations. Nat Hum Behav. 2017 Oct;1(10):757-765. doi: 10.1038/s41562-017-0195-1. Epub 2017 Sep 11. PMID: 29051922; PMCID: PMC5642946.
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Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data.

Journal of data mining in genomics & proteomics

Lubke G, Laurin C, Walters R, Eriksson N, Hysi P, Spector T, Montgomery G, Martin N, Medland S, Boomsma D.
PMID: 24404405
J Data Mining Genomics Proteomics. 2013 Oct 20;4. doi: 10.4172/2153-0602.1000143.

Typically, genome-wide association studies consist of regressing the phenotype on each SNP separately using an additive genetic model. Although statistical models for recessive, dominant, SNP-SNP, or SNP-environment interactions exist, the testing burden makes an evaluation of all possible effects...

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Lubke G, Laurin C, Walters R, et al. Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data. J Data Mining Genomics Proteomics. 2013;4doi: 10.4172/2153-0602.1000143.
Lubke, G., Laurin, C., Walters, R., Eriksson, N., Hysi, P., Spector, T., Montgomery, G., Martin, N., Medland, S., & Boomsma, D. (2013). Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data. Journal of data mining in genomics & proteomics, 4. https://doi.org/10.4172/2153-0602.1000143
Lubke, Gh, et al. "Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data." Journal of data mining in genomics & proteomics vol. 4 (2013). doi: https://doi.org/10.4172/2153-0602.1000143
Lubke G, Laurin C, Walters R, Eriksson N, Hysi P, Spector T, Montgomery G, Martin N, Medland S, Boomsma D. Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data. J Data Mining Genomics Proteomics. 2013 Oct 20;4. doi: 10.4172/2153-0602.1000143. PMID: 24404405; PMCID: PMC3882018.
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Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.

Science advances

Simcoe M, Valdes A, Liu F, Furlotte NA, Evans DM, Hemani G, Ring SM, Smith GD, Duffy DL, Zhu G, Gordon SD, Medland SE, Vuckovic D, Girotto G, Sala C, Catamo E, Concas MP, Brumat M, Gasparini P, Toniolo D, Cocca M, Robino A, Yazar S, Hewitt A, Wu W, Kraft P, Hammond CJ, Shi Y, Chen Y, Zeng C, Klaver CCW, Uitterlinden AG, Ikram MA, Hamer MA, van Duijn CM, Nijsten T, Han J, Mackey DA, Martin NG, Cheng CY, Hinds DA, Spector TD, Kayser M, Hysi PG.
PMID: 33692100
Sci Adv. 2021 Mar 10;7(11). doi: 10.1126/sciadv.abd1239. Print 2021 Mar.

Human eye color is highly heritable, but its genetic architecture is not yet fully understood. We report the results of the largest genome-wide association study for eye color to date, involving up to 192,986 European participants from 10 populations....

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Simcoe M, Valdes A, Liu F, et al. Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color. Sci Adv. 2021;7(11)doi: 10.1126/sciadv.abd1239.
Simcoe, M., Valdes, A., Liu, F., Furlotte, N. A., Evans, D. M., Hemani, G., Ring, S. M., Smith, G. D., Duffy, D. L., Zhu, G., Gordon, S. D., Medland, S. E., Vuckovic, D., Girotto, G., Sala, C., Catamo, E., Concas, M. P., Brumat, M., Gasparini, P., Toniolo, D., Cocca, M., Robino, A., Yazar, S., Hewitt, A., Wu, W., Kraft, P., Hammond, C. J., Shi, Y., Chen, Y., Zeng, C., Klaver, C. C. W., Uitterlinden, A. G., Ikram, M. A., Hamer, M. A., van Duijn, C. M., Nijsten, T., Han, J., Mackey, D. A., Martin, N. G., Cheng, C. Y., Hinds, D. A., Spector, T. D., Kayser, M., & Hysi, P. G. (2021). Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color. Science advances, 7(11), . https://doi.org/10.1126/sciadv.abd1239
Simcoe, Mark, et al. "Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color." Science advances vol. 7,11 (2021). doi: https://doi.org/10.1126/sciadv.abd1239
Simcoe M, Valdes A, Liu F, Furlotte NA, Evans DM, Hemani G, Ring SM, Smith GD, Duffy DL, Zhu G, Gordon SD, Medland SE, Vuckovic D, Girotto G, Sala C, Catamo E, Concas MP, Brumat M, Gasparini P, Toniolo D, Cocca M, Robino A, Yazar S, Hewitt A, Wu W, Kraft P, Hammond CJ, Shi Y, Chen Y, Zeng C, Klaver CCW, Uitterlinden AG, Ikram MA, Hamer MA, van Duijn CM, Nijsten T, Han J, Mackey DA, Martin NG, Cheng CY, Hinds DA, Spector TD, Kayser M, Hysi PG. Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color. Sci Adv. 2021 Mar 10;7(11). doi: 10.1126/sciadv.abd1239. Print 2021 Mar. PMID: 33692100; PMCID: PMC7946369.
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