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Showing 1 to 12 of 23 entries
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The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study.

Stroke

Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S.
PMID: 33874747
Stroke. 2021 Jun;52(6):2068-2076. doi: 10.1161/STROKEAHA.120.030601. Epub 2021 Apr 20.

BACKGROUND AND PURPOSE: The autonomic nervous system has been implicated in stroke and dementia pathophysiology. High resting heart rate and low heart rate variability indicate the effect of autonomic imbalance on the heart. We examined the associations of resting...

20th Workshop of the International Stroke Genetics Consortium, November 3-4, 2016, Milan, Italy: 2016.036 ISGC research priorities.

Neurology. Genetics

Woo D, Debette S, Anderson C.
PMID: 28428978
Neurol Genet. 2017 Mar 30;3(1):S12-S18. doi: 10.1212/NXG.0000000000000136. eCollection 2017 Mar.

OBJECTIVE: To develop a research priority list for the International Stroke Genetics Consortium (ISGC).BACKGROUND: Previously, stroke progress review groups and other activities provided an opportunity for members within the field to develop priorities for research. These filtered into larger...

Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences.

PLoS genetics

Zhan L, Li J, Jew B, Sul JH.
PMID: 34516545
PLoS Genet. 2021 Sep 13;17(9):e1009772. doi: 10.1371/journal.pgen.1009772. eCollection 2021 Sep.

Late-onset Alzheimer's disease (LOAD) is the most common type of dementia causing irreversible brain damage to the elderly and presents a major public health challenge. Clinical research and genome-wide association studies have suggested a potential contribution of the endocytic...

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study.

Alzheimer's & dementia (New York, N. Y.)

Spartano NL, Demissie S, Himali JJ, Dukes KA, Murabito JM, Vasan RS, Beiser AS, Seshadri S.
PMID: 31660424
Alzheimers Dement (N Y). 2019 Oct 15;5:618-626. doi: 10.1016/j.trci.2019.08.007. eCollection 2019.

INTRODUCTION: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease.METHODS: Cross-sectional regression analyses were performed in Framingham Heart Study Third...

Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study.

Stroke

Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S.
PMID: 33874747
Stroke. 2021 Jun;52(6):2068-2076. doi: 10.1161/STROKEAHA.120.030601. Epub 2021 Apr 20.

[Figure: see text].

Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts.

Neurology

Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM.
PMID: 33268560
Neurology. 2020 Dec 02; doi: 10.1212/WNL.0000000000011236. Epub 2020 Dec 02.

OBJECTIVE: To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings.METHODS: We investigated the association of metabolites with risk of stroke in seven prospective cohort studies including 1,791 incident stroke events among 38,797...

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Neurology

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT, Debette S.
PMID: 30651383
Neurology. 2019 Jan 16; doi: 10.1212/WNL.0000000000006851. Epub 2019 Jan 16.

OBJECTIVE: To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts.METHODS: We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with...

Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study.

Alzheimer's & dementia (New York, N. Y.)

Spartano NL, Demissie S, Himali JJ, Dukes KA, Murabito JM, Vasan RS, Beiser AS, Seshadri S.
PMID: 31660424
Alzheimers Dement (N Y). 2019 Oct 15;5:618-626. doi: 10.1016/j.trci.2019.08.007. eCollection 2019.

INTRODUCTION: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease.METHODS: Cross-sectional regression analyses were performed in Framingham Heart Study Third...

Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke.

Alzheimer's & dementia (Amsterdam, Netherlands)

Weinstein G, Beiser AS, Preis SR, Courchesne P, Chouraki V, Levy D, Seshadri S.
PMID: 27453932
Alzheimers Dement (Amst). 2016 Jul 09;3:103-9. doi: 10.1016/j.dadm.2016.06.005. eCollection 2016.

INTRODUCTION: Genetic variation in the clusterin gene has been associated with Alzheimer Disease (AD), and the clusterin protein is thought to play a mechanistic role. We explored the associations of clusterin plasma levels with incident dementia, AD, and stroke.METHODS:...

Showing 1 to 12 of 23 entries