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Association of History of Psychopathology With Accelerated Aging at Midlife.

JAMA psychiatry

Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington H, Hogan S, Houts RM, Leung JH, Poulton R, Purdy SC, Ramrakha S, Rasmussen LJH, Richmond-Rakerd LS, Thorne PR, Wilson GA, Moffitt TE.
PMID: 33595619
JAMA Psychiatry. 2021 May 01;78(5):530-539. doi: 10.1001/jamapsychiatry.2020.4626.

IMPORTANCE: Individuals with mental disorders are at an elevated risk of developing chronic age-related physical diseases. However, it is not clear whether psychopathology is also associated with processes of accelerated aging that precede the onset of age-related disease.OBJECTIVE: To...

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Wertz J, Caspi A, Ambler A, et al. Association of History of Psychopathology With Accelerated Aging at Midlife. JAMA Psychiatry. 2021;78(5):530-539doi: 10.1001/jamapsychiatry.2020.4626.
Wertz, J., Caspi, A., Ambler, A., Broadbent, J., Hancox, R. J., Harrington, H., Hogan, S., Houts, R. M., Leung, J. H., Poulton, R., Purdy, S. C., Ramrakha, S., Rasmussen, L. J. H., Richmond-Rakerd, L. S., Thorne, P. R., Wilson, G. A., & Moffitt, T. E. (2021). Association of History of Psychopathology With Accelerated Aging at Midlife. JAMA psychiatry, 78(5), 530-539. https://doi.org/10.1001/jamapsychiatry.2020.4626
Wertz, Jasmin, et al. "Association of History of Psychopathology With Accelerated Aging at Midlife." JAMA psychiatry vol. 78,5 (2021): 530-539. doi: https://doi.org/10.1001/jamapsychiatry.2020.4626
Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington H, Hogan S, Houts RM, Leung JH, Poulton R, Purdy SC, Ramrakha S, Rasmussen LJH, Richmond-Rakerd LS, Thorne PR, Wilson GA, Moffitt TE. Association of History of Psychopathology With Accelerated Aging at Midlife. JAMA Psychiatry. 2021 May 01;78(5):530-539. doi: 10.1001/jamapsychiatry.2020.4626. PMID: 33595619; PMCID: PMC7890535.
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Childhood forecasting of a small segment of the population with large economic burden.

Nature human behaviour

Caspi A, Houts RM, Belsky DW, Harrington H, Hogan S, Ramrakha S, Poulton R, Moffitt TE.
PMID: 28706997
Nat Hum Behav. 2016;1. doi: 10.1038/s41562-016-0005. Epub 2016 Dec 12.

Policy-makers are interested in early-years interventions to ameliorate childhood risks. They hope for improved adult outcomes in the long run, bringing return on investment. How much return can be expected depends, partly, on how strongly childhood risks forecast adult...

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Caspi A, Houts RM, Belsky DW, et al. Childhood forecasting of a small segment of the population with large economic burden. Nat Hum Behav. 2016;1doi: 10.1038/s41562-016-0005.
Caspi, A., Houts, R. M., Belsky, D. W., Harrington, H., Hogan, S., Ramrakha, S., Poulton, R., & Moffitt, T. E. (2016). Childhood forecasting of a small segment of the population with large economic burden. Nature human behaviour, 1. https://doi.org/10.1038/s41562-016-0005
Caspi, Avshalom, et al. "Childhood forecasting of a small segment of the population with large economic burden." Nature human behaviour vol. 1 (2016). doi: https://doi.org/10.1038/s41562-016-0005
Caspi A, Houts RM, Belsky DW, Harrington H, Hogan S, Ramrakha S, Poulton R, Moffitt TE. Childhood forecasting of a small segment of the population with large economic burden. Nat Hum Behav. 2016;1. doi: 10.1038/s41562-016-0005. Epub 2016 Dec 12. PMID: 28706997; PMCID: PMC5505663.
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The E Is in the G: Gene-Environment-Trait Correlations and Findings From Genome-Wide Association Studies.

Perspectives on psychological science : a journal of the Association for Psychological Science

Avinun R.
PMID: 31558103
Perspect Psychol Sci. 2020 Jan;15(1):81-89. doi: 10.1177/1745691619867107. Epub 2019 Sep 27.

Genome-wide association studies (GWASs) have shown that pleiotropy is widespread (i.e., the same genetic variants affect multiple traits) and that complex traits are polygenic (i.e., affected by many genetic variants with very small effect sizes). However, despite the growing...

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Avinun R. The E Is in the G: Gene-Environment-Trait Correlations and Findings From Genome-Wide Association Studies. Perspect Psychol Sci. 2019;15(1):81-89doi: 10.1177/1745691619867107.
Avinun, R. (2020). The E Is in the G: Gene-Environment-Trait Correlations and Findings From Genome-Wide Association Studies. Perspectives on psychological science : a journal of the Association for Psychological Science, 15(1), 81-89. https://doi.org/10.1177/1745691619867107
Avinun, Reut. "The E Is in the G: Gene-Environment-Trait Correlations and Findings From Genome-Wide Association Studies." Perspectives on psychological science : a journal of the Association for Psychological Science vol. 15,1 (2020): 81-89. doi: https://doi.org/10.1177/1745691619867107
Avinun R. The E Is in the G: Gene-Environment-Trait Correlations and Findings From Genome-Wide Association Studies. Perspect Psychol Sci. 2020 Jan;15(1):81-89. doi: 10.1177/1745691619867107. Epub 2019 Sep 27. PMID: 31558103; PMCID: PMC6980468.
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A BRIEF INTRODUCTION TO THE NEUROGENETICS OF COGNITION-EMOTION INTERACTIONS.

Current opinion in behavioral sciences

Scult MA, Hariri AR.
PMID: 29399606
Curr Opin Behav Sci. 2018 Feb;19:50-54. doi: 10.1016/j.cobeha.2017.09.014. Epub 2017 Oct 15.

Neuroscience research has demonstrated that cognition, emotion, and their dynamic interactions emerge from complex and flexible patterns of activity across distributed neural circuits. A parallel branch of research in genetics has begun to identify common variation in the human...

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Scult MA, Hariri AR. A BRIEF INTRODUCTION TO THE NEUROGENETICS OF COGNITION-EMOTION INTERACTIONS. Curr Opin Behav Sci. 2017;19:50-54doi: 10.1016/j.cobeha.2017.09.014.
Scult, M. A., & Hariri, A. R. (2018). A BRIEF INTRODUCTION TO THE NEUROGENETICS OF COGNITION-EMOTION INTERACTIONS. Current opinion in behavioral sciences, 1950-54. https://doi.org/10.1016/j.cobeha.2017.09.014
Scult, Matthew A, and Hariri, Ahmad R. "A BRIEF INTRODUCTION TO THE NEUROGENETICS OF COGNITION-EMOTION INTERACTIONS." Current opinion in behavioral sciences vol. 19 (2018): 50-54. doi: https://doi.org/10.1016/j.cobeha.2017.09.014
Scult MA, Hariri AR. A BRIEF INTRODUCTION TO THE NEUROGENETICS OF COGNITION-EMOTION INTERACTIONS. Curr Opin Behav Sci. 2018 Feb;19:50-54. doi: 10.1016/j.cobeha.2017.09.014. Epub 2017 Oct 15. PMID: 29399606; PMCID: PMC5790152.
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Dissecting the role of amygdala reactivity in antisocial behavior in a sample of young, low-income, urban men.

Clinical psychological science : a journal of the Association for Psychological Science

Hyde LW, Shaw DS, Murray L, Gard A, Hariri AR, Forbes EE.
PMID: 27429865
Clin Psychol Sci. 2016 May;4(3):527-544. doi: 10.1177/2167702615614511. Epub 2015 Dec 14.

Neuroimaging has suggested that amygdala reactivity to emotional facial expressions is associated with antisocial behavior (AB), particularly among those high on callous-unemotional (CU) traits. To investigate this association and potential moderators of this relationship, including task/stimuli effects, subregional anatomy...

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Hyde LW, Shaw DS, Murray L, et al. Dissecting the role of amygdala reactivity in antisocial behavior in a sample of young, low-income, urban men. Clin Psychol Sci. 2015;4(3):527-544doi: 10.1177/2167702615614511.
Hyde, L. W., Shaw, D. S., Murray, L., Gard, A., Hariri, A. R., & Forbes, E. E. (2016). Dissecting the role of amygdala reactivity in antisocial behavior in a sample of young, low-income, urban men. Clinical psychological science : a journal of the Association for Psychological Science, 4(3), 527-544. https://doi.org/10.1177/2167702615614511
Hyde, Luke W, et al. "Dissecting the role of amygdala reactivity in antisocial behavior in a sample of young, low-income, urban men." Clinical psychological science : a journal of the Association for Psychological Science vol. 4,3 (2016): 527-544. doi: https://doi.org/10.1177/2167702615614511
Hyde LW, Shaw DS, Murray L, Gard A, Hariri AR, Forbes EE. Dissecting the role of amygdala reactivity in antisocial behavior in a sample of young, low-income, urban men. Clin Psychol Sci. 2016 May;4(3):527-544. doi: 10.1177/2167702615614511. Epub 2015 Dec 14. PMID: 27429865; PMCID: PMC4941820.
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Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter.

Frontiers in aging neuroscience

d'Arbeloff T, Elliott ML, Knodt AR, Sison M, Melzer TR, Ireland D, Ramrakha S, Poulton R, Caspi A, Moffitt TE, Hariri AR.
PMID: 33889085
Front Aging Neurosci. 2021 Apr 06;13:652575. doi: 10.3389/fnagi.2021.652575. eCollection 2021.

Disappointing results from clinical trials designed to delay structural brain decline and the accompanying increase in risk for dementia in older adults have precipitated a shift in testing promising interventions from late in life toward midlife before irreversible damage...

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d'Arbeloff T, Elliott ML, Knodt AR, et al. Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter. Front Aging Neurosci. 2021;13:652575doi: 10.3389/fnagi.2021.652575.
d'Arbeloff, T., Elliott, M. L., Knodt, A. R., Sison, M., Melzer, T. R., Ireland, D., Ramrakha, S., Poulton, R., Caspi, A., Moffitt, T. E., & Hariri, A. R. (2021). Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter. Frontiers in aging neuroscience, 13652575. https://doi.org/10.3389/fnagi.2021.652575
d'Arbeloff, Tracy, et al. "Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter." Frontiers in aging neuroscience vol. 13 (2021): 652575. doi: https://doi.org/10.3389/fnagi.2021.652575
d'Arbeloff T, Elliott ML, Knodt AR, Sison M, Melzer TR, Ireland D, Ramrakha S, Poulton R, Caspi A, Moffitt TE, Hariri AR. Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter. Front Aging Neurosci. 2021 Apr 06;13:652575. doi: 10.3389/fnagi.2021.652575. eCollection 2021. PMID: 33889085; PMCID: PMC8055854.
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White matter hyperintensities are common in midlife and already associated with cognitive decline.

Brain communications

d'Arbeloff T, Elliott ML, Knodt AR, Melzer TR, Keenan R, Ireland D, Ramrakha S, Poulton R, Anderson T, Caspi A, Moffitt TE, Hariri AR.
PMID: 31894208
Brain Commun. 2019;1(1):fcz041. doi: 10.1093/braincomms/fcz041. Epub 2019 Dec 09.

White matter hyperintensities proliferate as the brain ages and are associated with increased risk for cognitive decline as well as Alzheimer's disease and related dementias. As such, white matter hyperintensities have been targeted as a surrogate biomarker in intervention...

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d'Arbeloff T, Elliott ML, Knodt AR, et al. White matter hyperintensities are common in midlife and already associated with cognitive decline. Brain Commun. 2019;1(1):fcz041doi: 10.1093/braincomms/fcz041.
d'Arbeloff, T., Elliott, M. L., Knodt, A. R., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., Anderson, T., Caspi, A., Moffitt, T. E., & Hariri, A. R. (2019). White matter hyperintensities are common in midlife and already associated with cognitive decline. Brain communications, 1(1), fcz041. https://doi.org/10.1093/braincomms/fcz041
d'Arbeloff, Tracy, et al. "White matter hyperintensities are common in midlife and already associated with cognitive decline." Brain communications vol. 1,1 (2019): fcz041. doi: https://doi.org/10.1093/braincomms/fcz041
d'Arbeloff T, Elliott ML, Knodt AR, Melzer TR, Keenan R, Ireland D, Ramrakha S, Poulton R, Anderson T, Caspi A, Moffitt TE, Hariri AR. White matter hyperintensities are common in midlife and already associated with cognitive decline. Brain Commun. 2019;1(1):fcz041. doi: 10.1093/braincomms/fcz041. Epub 2019 Dec 09. PMID: 31894208; PMCID: PMC6928390.
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Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts.

Development and psychopathology

Schaefer JD, Scult MA, Caspi A, Arseneault L, Belsky DW, Hariri AR, Harrington H, Houts R, Ramrakha S, Poulton R, Moffitt TE.
PMID: 29144220
Dev Psychopathol. 2017 Nov 16;1-15. doi: 10.1017/S095457941700164X. Epub 2017 Nov 16.

Cognitive impairment has been identified as an important aspect of major depressive disorder (MDD). We tested two theories regarding the association between MDD and cognitive functioning using data from longitudinal cohort studies. One theory, the cognitive reserve hypothesis, suggests...

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Schaefer JD, Scult MA, Caspi A, et al. Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts. Dev Psychopathol. 2017;1-15doi: 10.1017/S095457941700164X.
Schaefer, J. D., Scult, M. A., Caspi, A., Arseneault, L., Belsky, D. W., Hariri, A. R., Harrington, H., Houts, R., Ramrakha, S., Poulton, R., & Moffitt, T. E. (2017). Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts. Development and psychopathology, 1-15. https://doi.org/10.1017/S095457941700164X
Schaefer, Jonathan D, et al. "Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts." Development and psychopathology vol. (2017): 1-15. doi: https://doi.org/10.1017/S095457941700164X
Schaefer JD, Scult MA, Caspi A, Arseneault L, Belsky DW, Hariri AR, Harrington H, Houts R, Ramrakha S, Poulton R, Moffitt TE. Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts. Dev Psychopathol. 2017 Nov 16;1-15. doi: 10.1017/S095457941700164X. Epub 2017 Nov 16. PMID: 29144220; PMCID: PMC5842891.
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Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Carey CE, Knodt AR, Conley ED, Hariri AR, Bogdan R.
PMID: 28825048
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):180-187. doi: 10.1016/j.bpsc.2016.10.003.

BACKGROUND: Problematic alcohol use in adolescence and adulthood is a common and often debilitating correlate of childhood attention-deficit/hyperactivity disorder (ADHD). Converging evidence suggests that ADHD and problematic alcohol use share a common additive genetic basis, which may be mechanistically...

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Carey CE, Knodt AR, Conley ED, et al. Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(2):180-187doi: 10.1016/j.bpsc.2016.10.003.
Carey, C. E., Knodt, A. R., Conley, E. D., Hariri, A. R., & Bogdan, R. (2017). Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood. Biological psychiatry. Cognitive neuroscience and neuroimaging, 2(2), 180-187. https://doi.org/10.1016/j.bpsc.2016.10.003
Carey, Caitlin E, et al. "Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood." Biological psychiatry. Cognitive neuroscience and neuroimaging vol. 2,2 (2017): 180-187. doi: https://doi.org/10.1016/j.bpsc.2016.10.003
Carey CE, Knodt AR, Conley ED, Hariri AR, Bogdan R. Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):180-187. doi: 10.1016/j.bpsc.2016.10.003. PMID: 28825048; PMCID: PMC5560771.
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Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort.

Molecular psychiatry

Romer AL, Knodt AR, Sison ML, Ireland D, Houts R, Ramrakha S, Poulton R, Keenan R, Melzer TR, Moffitt TE, Caspi A, Hariri AR.
PMID: 31796893
Mol Psychiatry. 2021 Aug;26(8):3839-3846. doi: 10.1038/s41380-019-0621-z. Epub 2019 Dec 03.

Transdiagnostic research has identified a general psychopathology factor-often called the 'p' factor-that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in...

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Romer AL, Knodt AR, Sison ML, et al. Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort. Mol Psychiatry. 2019;26(8):3839-3846doi: 10.1038/s41380-019-0621-z.
Romer, A. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., Moffitt, T. E., Caspi, A., & Hariri, A. R. (2021). Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort. Molecular psychiatry, 26(8), 3839-3846. https://doi.org/10.1038/s41380-019-0621-z
Romer, Adrienne L, et al. "Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort." Molecular psychiatry vol. 26,8 (2021): 3839-3846. doi: https://doi.org/10.1038/s41380-019-0621-z
Romer AL, Knodt AR, Sison ML, Ireland D, Houts R, Ramrakha S, Poulton R, Keenan R, Melzer TR, Moffitt TE, Caspi A, Hariri AR. Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort. Mol Psychiatry. 2021 Aug;26(8):3839-3846. doi: 10.1038/s41380-019-0621-z. Epub 2019 Dec 03. PMID: 31796893; PMCID: PMC7266702.
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The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Gard AM, Waller R, Shaw DS, Forbes EE, Hariri AR, Hyde LW.
PMID: 29170760
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct;2(7):582-590. doi: 10.1016/j.bpsc.2017.06.005. Epub 2017 Jun 27.

BACKGROUND: Early life adversities including harsh parenting, maternal depression, neighborhood deprivation, and low family economic resources are more prevalent in low-income urban environments and are potent predictors of psychopathology, including, for boys, antisocial behavior (AB). However, little research has...

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Gard AM, Waller R, Shaw DS, et al. The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(7):582-590doi: 10.1016/j.bpsc.2017.06.005.
Gard, A. M., Waller, R., Shaw, D. S., Forbes, E. E., Hariri, A. R., & Hyde, L. W. (2017). The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood. Biological psychiatry. Cognitive neuroscience and neuroimaging, 2(7), 582-590. https://doi.org/10.1016/j.bpsc.2017.06.005
Gard, Arianna M, et al. "The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood." Biological psychiatry. Cognitive neuroscience and neuroimaging vol. 2,7 (2017): 582-590. doi: https://doi.org/10.1016/j.bpsc.2017.06.005
Gard AM, Waller R, Shaw DS, Forbes EE, Hariri AR, Hyde LW. The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct;2(7):582-590. doi: 10.1016/j.bpsc.2017.06.005. Epub 2017 Jun 27. PMID: 29170760; PMCID: PMC5695704.
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Male antisocial behaviour in adolescence and beyond.

Nature human behaviour

Moffitt TE.
PMID: 30271880
Nat Hum Behav. 2018;2:177-186. Epub 2018 Feb 21.

Male antisocial behavior is concentrated in the adolescent period of the life course, as documented by the curve of crime over age. This article reviews recent evidence regarding the hypothesis that the age-crime curve conceals two groups with different...

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Moffitt TE. Male antisocial behaviour in adolescence and beyond. Nat Hum Behav. 2018;2:177-186
Moffitt, T. E. (2018). Male antisocial behaviour in adolescence and beyond. Nature human behaviour, 2177-186.
Moffitt, Terrie E. "Male antisocial behaviour in adolescence and beyond." Nature human behaviour vol. 2 (2018): 177-186.
Moffitt TE. Male antisocial behaviour in adolescence and beyond. Nat Hum Behav. 2018;2:177-186. Epub 2018 Feb 21. PMID: 30271880; PMCID: PMC6157602.
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Showing 1 to 12 of 20 entries