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Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Malik R, Georgakis MK, Neitzel J, Rannikmäe K, Ewers M, Seshadri S, Sudlow CLM, Dichgans M.
PMID: 33749976
Alzheimers Dement. 2021 Sep;17(9):1422-1431. doi: 10.1002/alz.12320. Epub 2021 Mar 22.

INTRODUCTION: Midlife clustering of vascular risk factors has been associated with late-life dementia, but causal effects of individual biological and lifestyle factors remain largely unknown.METHODS: Among 229,976 individuals (mean follow-up 9 years), we explored whether midlife cardiovascular health measured...

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Malik R, Georgakis MK, Neitzel J, et al. Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank. Alzheimers Dement. 2021;17(9):1422-1431doi: 10.1002/alz.12320.
Malik, R., Georgakis, M. K., Neitzel, J., Rannikmäe, K., Ewers, M., Seshadri, S., Sudlow, C. L. M., & Dichgans, M. (2021). Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(9), 1422-1431. https://doi.org/10.1002/alz.12320
Malik, Rainer, et al. "Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17,9 (2021): 1422-1431. doi: https://doi.org/10.1002/alz.12320
Malik R, Georgakis MK, Neitzel J, Rannikmäe K, Ewers M, Seshadri S, Sudlow CLM, Dichgans M. Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank. Alzheimers Dement. 2021 Sep;17(9):1422-1431. doi: 10.1002/alz.12320. Epub 2021 Mar 22. PMID: 33749976.
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Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy.

Free neuropathology

Cherry JD, Agus F, Dixon E, Huber B, Alvarez VE, Mez J, McKee AC, Labadorf A, Stein TD.
PMID: 34485990
Free Neuropathol. 2021;2. doi: 10.17879/freeneuropathology-2021-3453. Epub 2021 Aug 17.

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative tauopathy found in individuals with a history of repetitive head impacts (RHI). Previous work has demonstrated that neuroinflammation is involved in CTE pathogenesis, however, the specific inflammatory mechanisms are still unclear....

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Cherry JD, Agus F, Dixon E, et al. Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy. Free Neuropathol. 2021;2doi: 10.17879/freeneuropathology-2021-3453.
Cherry, J. D., Agus, F., Dixon, E., Huber, B., Alvarez, V. E., Mez, J., McKee, A. C., Labadorf, A., & Stein, T. D. (2021). Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy. Free neuropathology, 2. https://doi.org/10.17879/freeneuropathology-2021-3453
Cherry, Jonathan D, et al. "Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy." Free neuropathology vol. 2 (2021). doi: https://doi.org/10.17879/freeneuropathology-2021-3453
Cherry JD, Agus F, Dixon E, Huber B, Alvarez VE, Mez J, McKee AC, Labadorf A, Stein TD. Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy. Free Neuropathol. 2021;2. doi: 10.17879/freeneuropathology-2021-3453. Epub 2021 Aug 17. PMID: 34485990; PMCID: PMC8415801.
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The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

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Li S, Weinstein G, Zare H, et al. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020;2(2):fcaa176doi: 10.1093/braincomms/fcaa176.
Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizabal, C. L., Petyuk, V. A., Adams, H. H. H., Launer, L. J., Bennett, D. A., De Jager, P. L., Grabe, H. J., Ikram, M. A., Gudnason, V., Yang, Q., & Seshadri, S. (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain communications, 2(2), fcaa176. https://doi.org/10.1093/braincomms/fcaa176
Li, Shuo, et al. "The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages." Brain communications vol. 2,2 (2020): fcaa176. doi: https://doi.org/10.1093/braincomms/fcaa176
Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020. PMID: 33345186; PMCID: PMC7734441.
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Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study.

Stroke

Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S.
PMID: 33874747
Stroke. 2021 Jun;52(6):2068-2076. doi: 10.1161/STROKEAHA.120.030601. Epub 2021 Apr 20.

BACKGROUND AND PURPOSE: The autonomic nervous system has been implicated in stroke and dementia pathophysiology. High resting heart rate and low heart rate variability indicate the effect of autonomic imbalance on the heart. We examined the associations of resting...

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Weinstein G, Davis-Plourde K, Beiser AS, et al. Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke. 2021;52(6):2068-2076doi: 10.1161/STROKEAHA.120.030601.
Weinstein, G., Davis-Plourde, K., Beiser, A. S., & Seshadri, S. (2021). Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke, 52(6), 2068-2076. https://doi.org/10.1161/STROKEAHA.120.030601
Weinstein, Galit, et al. "Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study." Stroke vol. 52,6 (2021): 2068-2076. doi: https://doi.org/10.1161/STROKEAHA.120.030601
Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke. 2021 Jun;52(6):2068-2076. doi: 10.1161/STROKEAHA.120.030601. Epub 2021 Apr 20. PMID: 33874747; PMCID: PMC8154675.
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Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings.

Alzheimer's & dementia (Amsterdam, Netherlands)

Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA.
PMID: 30976649
Alzheimers Dement (Amst). 2019 Mar 30;11:286-290. doi: 10.1016/j.dadm.2019.02.003. eCollection 2019 Dec.

Advances in technology enable increasing amounts of data collection from individuals for biomedical research. Such technologies, for example, in genetics and medical imaging, have also led to important scientific discoveries about health and disease. The combination of multiple types...

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Adams HHH, Roshchupkin GV, DeCarli C, et al. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019;11:286-290doi: 10.1016/j.dadm.2019.02.003.
Adams, H. H. H., Roshchupkin, G. V., DeCarli, C., Franke, B., Grabe, H. J., Habes, M., Jahanshad, N., Medland, S. E., Niessen, W., Satizabal, C. L., Schmidt, R., Seshadri, S., Teumer, A., Thompson, P. M., Vernooij, M. W., Wittfeld, K., & Ikram, M. A. (2019). Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimer's & dementia (Amsterdam, Netherlands), 11286-290. https://doi.org/10.1016/j.dadm.2019.02.003
Adams, Hieab H H, et al. "Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 11 (2019): 286-290. doi: https://doi.org/10.1016/j.dadm.2019.02.003
Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019 Mar 30;11:286-290. doi: 10.1016/j.dadm.2019.02.003. eCollection 2019 Dec. PMID: 30976649; PMCID: PMC6441785.
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Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia.

Alzheimer's & dementia (New York, N. Y.)

Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S.
PMID: 29067329
Alzheimers Dement (N Y). 2017 Mar 22;3(2):229-237. doi: 10.1016/j.trci.2017.03.001. eCollection 2017 Jun.

INTRODUCTION: Mechanisms underlying social determinants of stroke and dementia are unclear and brain-derived neurotrophic factor (BDNF) may contribute as a molecular link.METHODS: Using the Framingham Study, we examined social relationship measures as predictors of higher serum BDNF level and...

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Salinas J, Beiser A, Himali JJ, et al. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017;3(2):229-237doi: 10.1016/j.trci.2017.03.001.
Salinas, J., Beiser, A., Himali, J. J., Satizabal, C. L., Aparicio, H. J., Weinstein, G., Mateen, F. J., Berkman, L. F., Rosand, J., & Seshadri, S. (2017). Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimer's & dementia (New York, N. Y.), 3(2), 229-237. https://doi.org/10.1016/j.trci.2017.03.001
Salinas, Joel, et al. "Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia." Alzheimer's & dementia (New York, N. Y.) vol. 3,2 (2017): 229-237. doi: https://doi.org/10.1016/j.trci.2017.03.001
Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017 Mar 22;3(2):229-237. doi: 10.1016/j.trci.2017.03.001. eCollection 2017 Jun. PMID: 29067329; PMCID: PMC5651441.
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20th Workshop of the International Stroke Genetics Consortium, November 3-4, 2016, Milan, Italy: 2016.036 ISGC research priorities.

Neurology. Genetics

Woo D, Debette S, Anderson C.
PMID: 28428978
Neurol Genet. 2017 Mar 30;3(1):S12-S18. doi: 10.1212/NXG.0000000000000136. eCollection 2017 Mar.

OBJECTIVE: To develop a research priority list for the International Stroke Genetics Consortium (ISGC).BACKGROUND: Previously, stroke progress review groups and other activities provided an opportunity for members within the field to develop priorities for research. These filtered into larger...

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Woo D, Debette S, Anderson C. 20th Workshop of the International Stroke Genetics Consortium, November 3-4, 2016, Milan, Italy: 2016.036 ISGC research priorities. Neurol Genet. 2017;3(1):S12-S18doi: 10.1212/NXG.0000000000000136.
Woo, D., Debette, S., & Anderson, C. (2017). 20th Workshop of the International Stroke Genetics Consortium, November 3-4, 2016, Milan, Italy: 2016.036 ISGC research priorities. Neurology. Genetics, 3(1), S12-S18. https://doi.org/10.1212/NXG.0000000000000136
Woo, Daniel, et al. "20th Workshop of the International Stroke Genetics Consortium, November 3-4, 2016, Milan, Italy: 2016.036 ISGC research priorities." Neurology. Genetics vol. 3,1 (2017): S12-S18. doi: https://doi.org/10.1212/NXG.0000000000000136
Woo D, Debette S, Anderson C. 20th Workshop of the International Stroke Genetics Consortium, November 3-4, 2016, Milan, Italy: 2016.036 ISGC research priorities. Neurol Genet. 2017 Mar 30;3(1):S12-S18. doi: 10.1212/NXG.0000000000000136. eCollection 2017 Mar. PMID: 28428978; PMCID: PMC5390740.
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Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences.

PLoS genetics

Zhan L, Li J, Jew B, Sul JH.
PMID: 34516545
PLoS Genet. 2021 Sep 13;17(9):e1009772. doi: 10.1371/journal.pgen.1009772. eCollection 2021 Sep.

Late-onset Alzheimer's disease (LOAD) is the most common type of dementia causing irreversible brain damage to the elderly and presents a major public health challenge. Clinical research and genome-wide association studies have suggested a potential contribution of the endocytic...

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Zhan L, Li J, Jew B, et al. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. PLoS Genet. 2021;17(9):e1009772doi: 10.1371/journal.pgen.1009772.
Zhan, L., Li, J., Jew, B., & Sul, J. H. (2021). Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. PLoS genetics, 17(9), e1009772. https://doi.org/10.1371/journal.pgen.1009772
Zhan, Lingyu, et al. "Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences." PLoS genetics vol. 17,9 (2021): e1009772. doi: https://doi.org/10.1371/journal.pgen.1009772
Zhan L, Li J, Jew B, Sul JH. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. PLoS Genet. 2021 Sep 13;17(9):e1009772. doi: 10.1371/journal.pgen.1009772. eCollection 2021 Sep. PMID: 34516545; PMCID: PMC8460036.
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The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

Cite
Li S, Weinstein G, Zare H, et al. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020;2(2):fcaa176doi: 10.1093/braincomms/fcaa176.
Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizabal, C. L., Petyuk, V. A., Adams, H. H. H., Launer, L. J., Bennett, D. A., De Jager, P. L., Grabe, H. J., Ikram, M. A., Gudnason, V., Yang, Q., & Seshadri, S. (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain communications, 2(2), fcaa176. https://doi.org/10.1093/braincomms/fcaa176
Li, Shuo, et al. "The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages." Brain communications vol. 2,2 (2020): fcaa176. doi: https://doi.org/10.1093/braincomms/fcaa176
Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020. PMID: 33345186; PMCID: PMC7734441.
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Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study.

Alzheimer's & dementia (New York, N. Y.)

Spartano NL, Demissie S, Himali JJ, Dukes KA, Murabito JM, Vasan RS, Beiser AS, Seshadri S.
PMID: 31660424
Alzheimers Dement (N Y). 2019 Oct 15;5:618-626. doi: 10.1016/j.trci.2019.08.007. eCollection 2019.

INTRODUCTION: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease.METHODS: Cross-sectional regression analyses were performed in Framingham Heart Study Third...

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Spartano NL, Demissie S, Himali JJ, et al. Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. Alzheimers Dement (N Y). 2019;5:618-626doi: 10.1016/j.trci.2019.08.007.
Spartano, N. L., Demissie, S., Himali, J. J., Dukes, K. A., Murabito, J. M., Vasan, R. S., Beiser, A. S., & Seshadri, S. (2019). Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. Alzheimer's & dementia (New York, N. Y.), 5618-626. https://doi.org/10.1016/j.trci.2019.08.007
Spartano, Nicole L, et al. "Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study." Alzheimer's & dementia (New York, N. Y.) vol. 5 (2019): 618-626. doi: https://doi.org/10.1016/j.trci.2019.08.007
Spartano NL, Demissie S, Himali JJ, Dukes KA, Murabito JM, Vasan RS, Beiser AS, Seshadri S. Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. Alzheimers Dement (N Y). 2019 Oct 15;5:618-626. doi: 10.1016/j.trci.2019.08.007. eCollection 2019. PMID: 31660424; PMCID: PMC6807299.
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Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study.

Stroke

Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S.
PMID: 33874747
Stroke. 2021 Jun;52(6):2068-2076. doi: 10.1161/STROKEAHA.120.030601. Epub 2021 Apr 20.

[Figure: see text].

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Weinstein G, Davis-Plourde K, Beiser AS, et al. Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke. 2021;52(6):2068-2076doi: 10.1161/STROKEAHA.120.030601.
Weinstein, G., Davis-Plourde, K., Beiser, A. S., & Seshadri, S. (2021). Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke, 52(6), 2068-2076. https://doi.org/10.1161/STROKEAHA.120.030601
Weinstein, Galit, et al. "Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study." Stroke vol. 52,6 (2021): 2068-2076. doi: https://doi.org/10.1161/STROKEAHA.120.030601
Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke. 2021 Jun;52(6):2068-2076. doi: 10.1161/STROKEAHA.120.030601. Epub 2021 Apr 20. PMID: 33874747; PMCID: PMC8154675.
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Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts.

Neurology

Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM.
PMID: 33268560
Neurology. 2020 Dec 02; doi: 10.1212/WNL.0000000000011236. Epub 2020 Dec 02.

OBJECTIVE: To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings.METHODS: We investigated the association of metabolites with risk of stroke in seven prospective cohort studies including 1,791 incident stroke events among 38,797...

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Vojinovic D, Kalaoja M, Trompet S, et al. Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts. Neurology. 2020;doi: 10.1212/WNL.0000000000011236.
Vojinovic, D., Kalaoja, M., Trompet, S., Fischer, K., Shipley, M. J., Li, S., Havulinna, A. S., Perola, M., Salomaa, V., Yang, Q., Sattar, N., Jousilahti, P., Amin, N., Satizabal, C. L., Taba, N., Sabayan, B., Vasan, R. S., Ikram, M. A., Stott, D. J., Ala-Korpela, M., Jukema, J. W., Seshadri, S., Kettunen, J., Kivimaki, M., Esko, T., & van Duijn, C. M. (2020). Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts. Neurology, . https://doi.org/10.1212/WNL.0000000000011236
Vojinovic, Dina, et al. "Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts." Neurology vol. (2020). doi: https://doi.org/10.1212/WNL.0000000000011236
Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM. Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts. Neurology. 2020 Dec 02; doi: 10.1212/WNL.0000000000011236. Epub 2020 Dec 02. PMID: 33268560; PMCID: PMC8055347.
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