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Showing 1 to 11 of 11 entries
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Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies.

The American journal of psychiatry

Frank P, Jokela M, Batty GD, Cadar D, Steptoe A, Kivimäki M.
PMID: 34645276
Am J Psychiatry. 2021 Dec;178(12):1107-1118. doi: 10.1176/appi.ajp.2021.20121776. Epub 2021 Oct 14.

OBJECTIVE: Evidence from anti-inflammatory drug trials for the treatment of depression has been inconsistent. This may be ascribed to the differing symptom-specific effects of inflammation. Accordingly, the authors explored the associations between systemic inflammation and an array of individual...

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Frank P, Jokela M, Batty GD, et al. Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies. Am J Psychiatry. 2021;178(12):1107-1118doi: 10.1176/appi.ajp.2021.20121776.
Frank, P., Jokela, M., Batty, G. D., Cadar, D., Steptoe, A., & Kivimäki, M. (2021). Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies. The American journal of psychiatry, 178(12), 1107-1118. https://doi.org/10.1176/appi.ajp.2021.20121776
Frank, Philipp, et al. "Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies." The American journal of psychiatry vol. 178,12 (2021): 1107-1118. doi: https://doi.org/10.1176/appi.ajp.2021.20121776
Frank P, Jokela M, Batty GD, Cadar D, Steptoe A, Kivimäki M. Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies. Am J Psychiatry. 2021 Dec;178(12):1107-1118. doi: 10.1176/appi.ajp.2021.20121776. Epub 2021 Oct 14. PMID: 34645276.
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Physical activity and peripheral artery disease: Two prospective cohort studies and a systematic review.

Atherosclerosis

Heikkilä K, Coughlin PA, Pentti J, Kivimäki M, Halonen JI.
PMID: 31136912
Atherosclerosis. 2019 Jul;286:114-120. doi: 10.1016/j.atherosclerosis.2019.05.008. Epub 2019 May 10.

BACKGROUND AND AIMS: Physical activity is a modifiable risk factor for cardiovascular disease and an important therapy in individuals with intermittent claudication. However, its role in the development of peripheral artery disease (PAD) is unclear. We have examined the...

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Heikkilä K, Coughlin PA, Pentti J, et al. Physical activity and peripheral artery disease: Two prospective cohort studies and a systematic review. Atherosclerosis. 2019;286:114-120doi: 10.1016/j.atherosclerosis.2019.05.008.
Heikkilä, K., Coughlin, P. A., Pentti, J., Kivimäki, M., & Halonen, J. I. (2019). Physical activity and peripheral artery disease: Two prospective cohort studies and a systematic review. Atherosclerosis, 286114-120. https://doi.org/10.1016/j.atherosclerosis.2019.05.008
Heikkilä, Katriina, et al. "Physical activity and peripheral artery disease: Two prospective cohort studies and a systematic review." Atherosclerosis vol. 286 (2019): 114-120. doi: https://doi.org/10.1016/j.atherosclerosis.2019.05.008
Heikkilä K, Coughlin PA, Pentti J, Kivimäki M, Halonen JI. Physical activity and peripheral artery disease: Two prospective cohort studies and a systematic review. Atherosclerosis. 2019 Jul;286:114-120. doi: 10.1016/j.atherosclerosis.2019.05.008. Epub 2019 May 10. PMID: 31136912.
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Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study.

Brain communications

Zsoldos E, Mahmood A, Filippini N, Suri S, Heise V, Griffanti L, Mackay CE, Singh-Manoux A, Kivimäki M, Ebmeier KP.
PMID: 32954286
Brain Commun. 2020 Mar 07;2(1):fcaa026. doi: 10.1093/braincomms/fcaa026. eCollection 2020.

Cardiovascular health in midlife is an established risk factor for cognitive function later in life. Knowing mechanisms of this association may allow preventative steps to be taken to preserve brain health and cognitive performance in older age. In this...

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Zsoldos E, Mahmood A, Filippini N, et al. Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study. Brain Commun. 2020;2(1):fcaa026doi: 10.1093/braincomms/fcaa026.
Zsoldos, E., Mahmood, A., Filippini, N., Suri, S., Heise, V., Griffanti, L., Mackay, C. E., Singh-Manoux, A., Kivimäki, M., & Ebmeier, K. P. (2020). Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study. Brain communications, 2(1), fcaa026. https://doi.org/10.1093/braincomms/fcaa026
Zsoldos, Enikő, et al. "Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study." Brain communications vol. 2,1 (2020): fcaa026. doi: https://doi.org/10.1093/braincomms/fcaa026
Zsoldos E, Mahmood A, Filippini N, Suri S, Heise V, Griffanti L, Mackay CE, Singh-Manoux A, Kivimäki M, Ebmeier KP. Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study. Brain Commun. 2020 Mar 07;2(1):fcaa026. doi: 10.1093/braincomms/fcaa026. eCollection 2020. PMID: 32954286; PMCID: PMC7491431.
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Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort.

The Lancet. Infectious diseases

Sipilä PN, Heikkilä N, Lindbohm JV, Hakulinen C, Vahtera J, Elovainio M, Suominen S, Väänänen A, Koskinen A, Nyberg ST, Pentti J, Strandberg TE, Kivimäki M.
PMID: 34166620
Lancet Infect Dis. 2021 Nov;21(11):1557-1567. doi: 10.1016/S1473-3099(21)00144-4. Epub 2021 Jun 21.

BACKGROUND: Infections have been hypothesised to increase the risk of dementia. Existing studies have included a narrow range of infectious diseases, relied on short follow-up periods, and provided little evidence for whether the increased risk is limited to specific...

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Sipilä PN, Heikkilä N, Lindbohm JV, et al. Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort. Lancet Infect Dis. 2021;21(11):1557-1567doi: 10.1016/S1473-3099(21)00144-4.
Sipilä, P. N., Heikkilä, N., Lindbohm, J. V., Hakulinen, C., Vahtera, J., Elovainio, M., Suominen, S., Väänänen, A., Koskinen, A., Nyberg, S. T., Pentti, J., Strandberg, T. E., & Kivimäki, M. (2021). Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort. The Lancet. Infectious diseases, 21(11), 1557-1567. https://doi.org/10.1016/S1473-3099(21)00144-4
Sipilä, Pyry N, et al. "Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort." The Lancet. Infectious diseases vol. 21,11 (2021): 1557-1567. doi: https://doi.org/10.1016/S1473-3099(21)00144-4
Sipilä PN, Heikkilä N, Lindbohm JV, Hakulinen C, Vahtera J, Elovainio M, Suominen S, Väänänen A, Koskinen A, Nyberg ST, Pentti J, Strandberg TE, Kivimäki M. Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort. Lancet Infect Dis. 2021 Nov;21(11):1557-1567. doi: 10.1016/S1473-3099(21)00144-4. Epub 2021 Jun 21. PMID: 34166620; PMCID: PMC8592915.
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Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics.

Nature communications

Gordillo-Marañón M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, Engmann J, Chaturvedi N, Papacosta O, Wannamethee G, Wong A, Sofat R, Kivimaki M, Price JF, Hughes AD, Gaunt TR, Lawlor DA, Gaulton A, Hingorani AD, Schmidt AF, Finan C.
PMID: 34675202
Nat Commun. 2021 Oct 21;12(1):6120. doi: 10.1038/s41467-021-25731-z.

Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target's expression or function, as a tool to anticipate the effect of drug action on the same...

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Gordillo-Marañón M, Zwierzyna M, Charoen P, et al. Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nat Commun. 2021;12(1):6120doi: 10.1038/s41467-021-25731-z.
Gordillo-Marañón, M., Zwierzyna, M., Charoen, P., Drenos, F., Chopade, S., Shah, T., Engmann, J., Chaturvedi, N., Papacosta, O., Wannamethee, G., Wong, A., Sofat, R., Kivimaki, M., Price, J. F., Hughes, A. D., Gaunt, T. R., Lawlor, D. A., Gaulton, A., Hingorani, A. D., Schmidt, A. F., & Finan, C. (2021). Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nature communications, 12(1), 6120. https://doi.org/10.1038/s41467-021-25731-z
Gordillo-Marañón, María, et al. "Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics." Nature communications vol. 12,1 (2021): 6120. doi: https://doi.org/10.1038/s41467-021-25731-z
Gordillo-Marañón M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, Engmann J, Chaturvedi N, Papacosta O, Wannamethee G, Wong A, Sofat R, Kivimaki M, Price JF, Hughes AD, Gaunt TR, Lawlor DA, Gaulton A, Hingorani AD, Schmidt AF, Finan C. Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nat Commun. 2021 Oct 21;12(1):6120. doi: 10.1038/s41467-021-25731-z. PMID: 34675202; PMCID: PMC8531035.
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Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort.

The Lancet. Infectious diseases

Sipilä PN, Heikkilä N, Lindbohm JV, Hakulinen C, Vahtera J, Elovainio M, Suominen S, Väänänen A, Koskinen A, Nyberg ST, Pentti J, Strandberg TE, Kivimäki M.
PMID: 34166620
Lancet Infect Dis. 2021 Nov;21(11):1557-1567. doi: 10.1016/S1473-3099(21)00144-4. Epub 2021 Jun 21.

BACKGROUND: Infections have been hypothesised to increase the risk of dementia. Existing studies have included a narrow range of infectious diseases, relied on short follow-up periods, and provided little evidence for whether the increased risk is limited to specific...

Cite
Sipilä PN, Heikkilä N, Lindbohm JV, et al. Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort. Lancet Infect Dis. 2021;21(11):1557-1567doi: 10.1016/S1473-3099(21)00144-4.
Sipilä, P. N., Heikkilä, N., Lindbohm, J. V., Hakulinen, C., Vahtera, J., Elovainio, M., Suominen, S., Väänänen, A., Koskinen, A., Nyberg, S. T., Pentti, J., Strandberg, T. E., & Kivimäki, M. (2021). Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort. The Lancet. Infectious diseases, 21(11), 1557-1567. https://doi.org/10.1016/S1473-3099(21)00144-4
Sipilä, Pyry N, et al. "Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort." The Lancet. Infectious diseases vol. 21,11 (2021): 1557-1567. doi: https://doi.org/10.1016/S1473-3099(21)00144-4
Sipilä PN, Heikkilä N, Lindbohm JV, Hakulinen C, Vahtera J, Elovainio M, Suominen S, Väänänen A, Koskinen A, Nyberg ST, Pentti J, Strandberg TE, Kivimäki M. Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort. Lancet Infect Dis. 2021 Nov;21(11):1557-1567. doi: 10.1016/S1473-3099(21)00144-4. Epub 2021 Jun 21. PMID: 34166620; PMCID: PMC8592915.
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Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population.

medRxiv : the preprint server for health sciences

Batty GD, Deary I, Luciano M, Altschul D, Kivimaki M, Gale C.
PMID: 32577689
medRxiv. 2020 Jun 01; doi: 10.1101/2020.05.29.20100735.

OBJECTIVE: To examine the association of a range of psychosocial factors with hospitalisation for COVID-19.DESIGN: Prospective cohort study.SETTING: England.PARTICIPANTS: UK Biobank comprises around half a million people who were aged 40 to 69 years at study induction between 2006...

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Batty GD, Deary I, Luciano M, et al. Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population. medRxiv. 2020;doi: 10.1101/2020.05.29.20100735.
Batty, G. D., Deary, I., Luciano, M., Altschul, D., Kivimaki, M., & Gale, C. (2020). Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2020.05.29.20100735
Batty, George David, et al. "Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population." medRxiv : the preprint server for health sciences vol. (2020). doi: https://doi.org/10.1101/2020.05.29.20100735
Batty GD, Deary I, Luciano M, Altschul D, Kivimaki M, Gale C. Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population. medRxiv. 2020 Jun 01; doi: 10.1101/2020.05.29.20100735. PMID: 32577689; PMCID: PMC7302298.
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Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study.

EClinicalMedicine

Chadeau-Hyam M, Bodinier B, Vermeulen R, Karimi M, Zuber V, Castagné R, Elliott J, Muller D, Petrovic D, Whitaker M, Stringhini S, Tzoulaki I, Kivimäki M, Vineis P, Elliott P, Kelly-Irving M, Delpierre C.
PMID: 33437953
EClinicalMedicine. 2020 Nov 19;29:100658. doi: 10.1016/j.eclinm.2020.100658. eCollection 2020 Dec.

BACKGROUND: Socioeconomic position as measured by education may be embodied and affect the functioning of key physiological systems. Links between social disadvantage, its biological imprint, and cause-specific mortality and morbidity have not been investigated in large populations, and yet...

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Chadeau-Hyam M, Bodinier B, Vermeulen R, et al. Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study. EClinicalMedicine. 2020;29:100658doi: 10.1016/j.eclinm.2020.100658.
Chadeau-Hyam, M., Bodinier, B., Vermeulen, R., Karimi, M., Zuber, V., Castagné, R., Elliott, J., Muller, D., Petrovic, D., Whitaker, M., Stringhini, S., Tzoulaki, I., Kivimäki, M., Vineis, P., Elliott, P., Kelly-Irving, M., & Delpierre, C. (2020). Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study. EClinicalMedicine, 29100658. https://doi.org/10.1016/j.eclinm.2020.100658
Chadeau-Hyam, Marc, et al. "Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study." EClinicalMedicine vol. 29 (2020): 100658. doi: https://doi.org/10.1016/j.eclinm.2020.100658
Chadeau-Hyam M, Bodinier B, Vermeulen R, Karimi M, Zuber V, Castagné R, Elliott J, Muller D, Petrovic D, Whitaker M, Stringhini S, Tzoulaki I, Kivimäki M, Vineis P, Elliott P, Kelly-Irving M, Delpierre C. Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study. EClinicalMedicine. 2020 Nov 19;29:100658. doi: 10.1016/j.eclinm.2020.100658. eCollection 2020 Dec. PMID: 33437953; PMCID: PMC7788440.
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Lifestyle Risk Factors for Cardiovascular Disease in Relation to COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK.

medRxiv : the preprint server for health sciences

Hamer M, Kivimäki M, Gale CR, Batty GD.
PMID: 32511498
medRxiv. 2020 May 13; doi: 10.1101/2020.05.09.20096438.

AIMS: It is important to identify characteristics of people who may be most at risk of COVID-19 to inform policy and intervention. Little is known about the impact of unhealthy lifestyles including smoking, physical inactivity, obesity, and excessive alcohol...

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Hamer M, Kivimäki M, Gale CR, et al. Lifestyle Risk Factors for Cardiovascular Disease in Relation to COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK. medRxiv. 2020;doi: 10.1101/2020.05.09.20096438.
Hamer, M., Kivimäki, M., Gale, C. R., & Batty, G. D. (2020). Lifestyle Risk Factors for Cardiovascular Disease in Relation to COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2020.05.09.20096438
Hamer, Mark, et al. "Lifestyle Risk Factors for Cardiovascular Disease in Relation to COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK." medRxiv : the preprint server for health sciences vol. (2020). doi: https://doi.org/10.1101/2020.05.09.20096438
Hamer M, Kivimäki M, Gale CR, Batty GD. Lifestyle Risk Factors for Cardiovascular Disease in Relation to COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK. medRxiv. 2020 May 13; doi: 10.1101/2020.05.09.20096438. PMID: 32511498; PMCID: PMC7273266.
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Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.

International journal of obesity (2005)

Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M, Tabak A, Singh-Manoux A, Wilson J, Langenberg C, Wareham N, Boniface D, Hingorani A, Kivimäki M, Llewellyn C.
PMID: 33446837
Int J Obes (Lond). 2021 Apr;45(4):758-765. doi: 10.1038/s41366-020-00735-9. Epub 2021 Jan 14.

BACKGROUND/OBJECTIVES: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain.SUBJECTS/METHODS: We followed...

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Brunner EJ, Maruyama K, Shipley M, et al. Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory. Int J Obes (Lond). 2021;45(4):758-765doi: 10.1038/s41366-020-00735-9.
Brunner, E. J., Maruyama, K., Shipley, M., Cable, N., Iso, H., Hiyoshi, A., Stallone, D., Kumari, M., Tabak, A., Singh-Manoux, A., Wilson, J., Langenberg, C., Wareham, N., Boniface, D., Hingorani, A., Kivimäki, M., & Llewellyn, C. (2021). Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory. International journal of obesity (2005), 45(4), 758-765. https://doi.org/10.1038/s41366-020-00735-9
Brunner, Eric J, et al. "Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory." International journal of obesity (2005) vol. 45,4 (2021): 758-765. doi: https://doi.org/10.1038/s41366-020-00735-9
Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M, Tabak A, Singh-Manoux A, Wilson J, Langenberg C, Wareham N, Boniface D, Hingorani A, Kivimäki M, Llewellyn C. Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory. Int J Obes (Lond). 2021 Apr;45(4):758-765. doi: 10.1038/s41366-020-00735-9. Epub 2021 Jan 14. PMID: 33446837; PMCID: PMC8005371.
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Structural social relations and cognitive ageing trajectories: evidence from the Whitehall II cohort study.

International journal of epidemiology

Elovainio M, Sommerlad A, Hakulinen C, Pulkki-Råback L, Virtanen M, Kivimäki M, Singh-Manoux A.
PMID: 29121238
Int J Epidemiol. 2018 Jun 01;47(3):701-708. doi: 10.1093/ije/dyx209.

BACKGROUND: Social relations are important for health, particularly at older ages. We examined the salience of frequency of social contacts and marital status for cognitive ageing trajectories over 21 years, from midlife to early old age.METHODS: Data are from...

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Elovainio M, Sommerlad A, Hakulinen C, et al. Structural social relations and cognitive ageing trajectories: evidence from the Whitehall II cohort study. Int J Epidemiol. 2018;47(3):701-708doi: 10.1093/ije/dyx209.
Elovainio, M., Sommerlad, A., Hakulinen, C., Pulkki-Råback, L., Virtanen, M., Kivimäki, M., & Singh-Manoux, A. (2018). Structural social relations and cognitive ageing trajectories: evidence from the Whitehall II cohort study. International journal of epidemiology, 47(3), 701-708. https://doi.org/10.1093/ije/dyx209
Elovainio, Marko, et al. "Structural social relations and cognitive ageing trajectories: evidence from the Whitehall II cohort study." International journal of epidemiology vol. 47,3 (2018): 701-708. doi: https://doi.org/10.1093/ije/dyx209
Elovainio M, Sommerlad A, Hakulinen C, Pulkki-Råback L, Virtanen M, Kivimäki M, Singh-Manoux A. Structural social relations and cognitive ageing trajectories: evidence from the Whitehall II cohort study. Int J Epidemiol. 2018 Jun 01;47(3):701-708. doi: 10.1093/ije/dyx209. PMID: 29121238; PMCID: PMC6005021.
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