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Showing 1 to 7 of 7 entries
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Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons.

JAMA psychiatry

Yu L, Tasaki S, Schneider JA, Arfanakis K, Duong DM, Wingo AP, Wingo TS, Kearns N, Thatcher GRJ, Seyfried NT, Levey AI, De Jager PL, Bennett DA.
PMID: 32609320
JAMA Psychiatry. 2020 Nov 01;77(11):1172-1180. doi: 10.1001/jamapsychiatry.2020.1807.

IMPORTANCE: Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics...

Effects of .

Frontiers in molecular neuroscience

Dai J, Johnson ECB, Dammer EB, Duong DM, Gearing M, Lah JJ, Levey AI, Wingo TS, Seyfried NT.
PMID: 30618606
Front Mol Neurosci. 2018 Dec 18;11:454. doi: 10.3389/fnmol.2018.00454. eCollection 2018.

Polymorphic alleles in the apolipoprotein E (

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia.

NPJ genomic medicine

Wingo TS, Yang J, Fan W, Min Canon S, Gerasimov ES, Lori A, Logsdon B, Yao B, Seyfried NT, Lah JJ, Levey AI, Boyle PA, Schneider JA, De Jager PL, Bennett DA, Wingo AP.
PMID: 32047652
NPJ Genom Med. 2020 Feb 06;5:6. doi: 10.1038/s41525-019-0113-8. eCollection 2020.

Late-life depression is associated with an increased risk for dementia but we have limited knowledge of the molecular mechanisms underlying this association. Here we investigated whether brain microRNAs, important posttranscriptional regulators of gene expression, contribute to this association. Late-life...

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons.

JAMA psychiatry

Yu L, Tasaki S, Schneider JA, Arfanakis K, Duong DM, Wingo AP, Wingo TS, Kearns N, Thatcher GRJ, Seyfried NT, Levey AI, De Jager PL, Bennett DA.
PMID: 32609320
JAMA Psychiatry. 2020 Nov 01;77(11):1172-1180. doi: 10.1001/jamapsychiatry.2020.1807.

IMPORTANCE: Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics...

Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline.

Biological psychiatry

Hüls A, Robins C, Conneely KN, Edgar R, De Jager PL, Bennett DA, Wingo AP, Epstein MP, Wingo TS.
PMID: 33838873
Biol Psychiatry. 2021 Feb 03; doi: 10.1016/j.biopsych.2021.01.015. Epub 2021 Feb 03.

BACKGROUND: Cognitive trajectory varies widely and can distinguish people who develop dementia from people who remain cognitively normal. Variation in cognitive trajectory is only partially explained by traditional neuropathologies. We sought to identify novel genes associated with cognitive trajectory...

Editorial: Non-Coding RNAs and Human Diseases.

Frontiers in genetics

Li Y, Shan G, Teng ZQ, Wingo TS.
PMID: 32528532
Front Genet. 2020 May 25;11:523. doi: 10.3389/fgene.2020.00523. eCollection 2020.

No abstract available.

A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with .

Genes

Vattathil SM, Liu Y, Harerimana NV, Lori A, Gerasimov ES, Beach TG, Reiman EM, De Jager PL, Schneider JA, Bennett DA, Seyfried NT, Levey AI, Wingo AP, Wingo TS.
PMID: 34073619
Genes (Basel). 2021 May 26;12(6). doi: 10.3390/genes12060815.

Cerebral atherosclerosis is a leading cause of stroke and an important contributor to dementia. Yet little is known about its genetic basis. To examine the association of common single nucleotide polymorphisms with cerebral atherosclerosis severity, we conducted a genomewide...

Showing 1 to 7 of 7 entries