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Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis.

Journal of inflammation (London, England)

Soltys J, Wu X.
PMID: 22642809
J Inflamm (Lond). 2012 May 29;9(1):20. doi: 10.1186/1476-9255-9-20.

BACKGROUND: Myasthenia gravis (MG) and animal model of experimental autoimmune myasthenia gravis (EAMG) is the most common autoimmune disorder of neuromuscular transmission. The disease is caused by the breakdown of the acetylcholine receptor (AChR) which is largely due to...

The role of the immune response in age-related macular degeneration.

International journal of inflammation

Whitcup SM, Sodhi A, Atkinson JP, Holers VM, Sinha D, Rohrer B, Dick AD.
PMID: 23762772
Int J Inflam. 2013;2013:348092. doi: 10.1155/2013/348092. Epub 2013 May 23.

Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries; with the aging population, the negative health impacts and costs of the disease will increase dramatically over the next decade. Although the exact cause of AMD...

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases.

Frontiers in immunology

Lintner KE, Wu YL, Yang Y, Spencer CH, Hauptmann G, Hebert LA, Atkinson JP, Yu CY.
PMID: 26913032
Front Immunol. 2016 Feb 15;7:36. doi: 10.3389/fimmu.2016.00036. eCollection 2016.

The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated tissue injury, most notably systemic...

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