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Showing 1 to 6 of 6 entries
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Metabolic Model-Based Integration of Microbiome Taxonomic and Metabolomic Profiles Elucidates Mechanistic Links between Ecological and Metabolic Variation.

mSystems

Noecker C, Eng A, Srinivasan S, Theriot CM, Young VB, Jansson JK, Fredricks DN, Borenstein E.
PMID: 27239563
mSystems. 2016 Jan-Feb;1(1). doi: 10.1128/mSystems.00013-15. Epub 2016 Jan 19.

Multiple molecular assays now enable high-throughput profiling of the ecology, metabolic capacity, and activity of the human microbiome. However, to date, analyses of such multi-omic data typically focus on statistical associations, often ignoring extensive prior knowledge of the mechanisms...

Bacterial Communities Associated With Abnormal Nugent Score in Postmenopausal Versus Premenopausal Women.

The Journal of infectious diseases

Mitchell CM, Srinivasan S, Ma N, Reed SD, Wu MC, Hoffman NG, Valint DJ, Proll S, Fiedler TL, Agnew KJ, Guthrie KA, Fredricks DN.
PMID: 33107562
J Infect Dis. 2021 Jun 15;223(12):2048-2052. doi: 10.1093/infdis/jiaa675.

The Nugent score is the reference standard for bacterial vaginosis (BV) diagnosis but has not been validated in postmenopausal women. We compared relative abundances from 16S ribosomal RNA gene sequencing of vaginal microbiota with Nugent score in cohorts of...

Bacterial Communities Associated With Abnormal Nugent Score in Postmenopausal Versus Premenopausal Women.

The Journal of infectious diseases

Mitchell CM, Srinivasan S, Ma N, Reed SD, Wu MC, Hoffman NG, Valint DJ, Proll S, Fiedler TL, Agnew KJ, Guthrie KA, Fredricks DN.
PMID: 33107562
J Infect Dis. 2021 Jun 15;223(12):2048-2052. doi: 10.1093/infdis/jiaa675.

The Nugent score is the reference standard for bacterial vaginosis (BV) diagnosis but has not been validated in postmenopausal women. We compared relative abundances from 16S ribosomal RNA gene sequencing of vaginal microbiota with Nugent score in cohorts of...

The human vaginal bacterial biota and bacterial vaginosis.

Interdisciplinary perspectives on infectious diseases

Srinivasan S, Fredricks DN.
PMID: 19282975
Interdiscip Perspect Infect Dis. 2008;2008:750479. doi: 10.1155/2008/750479. Epub 2009 Feb 16.

The bacterial biota of the human vagina can have a profound impact on the health of women and their neonates. Changes in the vaginal microbiota have been associated with several adverse health outcomes including premature birth, pelvic inflammatory disease,...

Molecular methodology in determining vaginal flora in health and disease: its time has come.

Current infectious disease reports

Fredricks DN, Marrazzo JM.
PMID: 16225785
Curr Infect Dis Rep. 2005 Nov;7(6):463-70. doi: 10.1007/s11908-005-0049-2.

The microbial flora of the human vagina can affect the health of women, their fetuses, and newborns. Conventional cultivation methods fail to detect some fastidious vaginal bacteria, leading to an incomplete census. Recent advances in molecular biology have facilitated...

Extra-vaginal Bacterial Colonization and Risk for Incident Bacterial Vaginosis in a Population of Women who Have Sex with Men.

The Journal of infectious diseases

Fredricks DN, Plantinga A, Srinivasan S, Oot A, Wiser A, Fiedler TL, Proll S, Wu MC, Marrazzo JM.
PMID: 32379324
J Infect Dis. 2020 May 07; doi: 10.1093/infdis/jiaa233. Epub 2020 May 07.

Bacterial vaginosis (BV) is a common cause of vaginal discharge and associated with vaginal acquisition of BV-associated bacteria (BVAB). We used quantitative PCR assays to determine if presence or concentrations of BVAB in the mouth, anus, vagina, or labia...

Showing 1 to 6 of 6 entries