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NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury.

Frontiers in immunology

Almyroudis NG, Grimm MJ, Davidson BA, Röhm M, Urban CF, Segal BH.
PMID: 23459634
Front Immunol. 2013 Mar 01;4:45. doi: 10.3389/fimmu.2013.00045. eCollection 2013.

Neutrophils are armed with both oxidant-dependent and -independent pathways for killing pathogens. Activation of the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase constitutes an emergency response to infectious threat and results in the generation of antimicrobial reactive oxidants. In...

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