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Showing 1 to 12 of 19 entries
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Development and application of an interaction network ontology for literature mining of vaccine-associated gene-gene interactions.

Journal of biomedical semantics

Hur J, Özgür A, Xiang Z, He Y.
PMID: 25785184
J Biomed Semantics. 2015 Jan 06;6:2. doi: 10.1186/2041-1480-6-2. eCollection 2015.

BACKGROUND: Literature mining of gene-gene interactions has been enhanced by ontology-based name classifications. However, in biomedical literature mining, interaction keywords have not been carefully studied and used beyond a collection of keywords.METHODS: In this study, we report the development...

Ontorat: automatic generation of new ontology terms, annotations, and axioms based on ontology design patterns.

Journal of biomedical semantics

Xiang Z, Zheng J, Lin Y, He Y.
PMID: 25785185
J Biomed Semantics. 2015 Jan 09;6:4. doi: 10.1186/2041-1480-6-4. eCollection 2015.

BACKGROUND: It is time-consuming to build an ontology with many terms and axioms. Thus it is desired to automate the process of ontology development. Ontology Design Patterns (ODPs) provide a reusable solution to solve a recurrent modeling problem in...

Identification of New Features from Known Bacterial Protective Vaccine Antigens Enhances Rational Vaccine Design.

Frontiers in immunology

Ong E, Wong MU, He Y.
PMID: 29123525
Front Immunol. 2017 Oct 26;8:1382. doi: 10.3389/fimmu.2017.01382. eCollection 2017.

With many protective vaccine antigens reported in the literature and verified experimentally, how to use the knowledge mined from these antigens to support rational vaccine design and study underlying design mechanism remains unclear. In order to address the problem,...

Integrative representations and analyses of vaccine-induced intended protective immunity and unintended adverse events using ontology-based and theory-guided approaches.

Global vaccines and immunology

He Y, Ong E, Xie J.
PMID: 27868103
Glob Vaccines Immunol. 2016 Jun;1(2):37-39. doi: 10.15761/GVI.1000110. Epub 2016 May 23.

No abstract available.

Ontology-based representation and analysis of host-Brucella interactions.

Journal of biomedical semantics

Lin Y, Xiang Z, He Y.
PMID: 26445639
J Biomed Semantics. 2015 Oct 05;6:37. doi: 10.1186/s13326-015-0036-y. eCollection 2015.

BACKGROUND: Biomedical ontologies are representations of classes of entities in the biomedical domain and how these classes are related in computer- and human-interpretable formats. Ontologies support data standardization and exchange and provide a basis for computer-assisted automated reasoning. IDOBRU...

Ontodog: a web-based ontology community view generation tool.

Bioinformatics (Oxford, England)

Zheng J, Xiang Z, Stoeckert CJ, He Y.
PMID: 24413522
Bioinformatics. 2014 May 01;30(9):1340-2. doi: 10.1093/bioinformatics/btu008. Epub 2014 Jan 09.

Biomedical ontologies are often very large and complex. Only a subset of the ontology may be needed for a specified application or community. For ontology end users, it is desirable to have community-based labels rather than the labels generated...

Modeling biomedical experimental processes with OBI.

Journal of biomedical semantics

Brinkman RR, Courtot M, Derom D, Fostel JM, He Y, Lord P, Malone J, Parkinson H, Peters B, Rocca-Serra P, Ruttenberg A, Sansone SA, Soldatova LN, Stoeckert CJ, Turner JA, Zheng J.
PMID: 20626927
J Biomed Semantics. 2010 Jun 22;1:S7. doi: 10.1186/2041-1480-1-S1-S7.

BACKGROUND: Experimental descriptions are typically stored as free text without using standardized terminology, creating challenges in comparison, reproduction and analysis. These difficulties impose limitations on data exchange and information retrieval.RESULTS: The Ontology for Biomedical Investigations (OBI), developed as a...

Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN.

Immunome research

He Y, Xiang Z.
PMID: 20875156
Immunome Res. 2010 Sep 27;6:S5. doi: 10.1186/1745-7580-6-S1-S5.

BACKGROUND: Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis, one of the commonest zoonotic diseases found worldwide in humans and a variety of animal species. While several animal vaccines are available, there is no effective and safe...

OntoFox: web-based support for ontology reuse.

BMC research notes

Xiang Z, Courtot M, Brinkman RR, Ruttenberg A, He Y.
PMID: 20569493
BMC Res Notes. 2010 Jun 22;3:175. doi: 10.1186/1756-0500-3-175.

BACKGROUND: Ontology development is a rapidly growing area of research, especially in the life sciences domain. To promote collaboration and interoperability between different projects, the OBO Foundry principles require that these ontologies be open and non-redundant, avoiding duplication of...

Cwl0971, a novel peptidoglycan hydrolase, plays pleiotropic roles in Clostridioides difficile R20291.

Environmental microbiology

Zhu D, Patabendige HMLW, Tomlinson BR, Wang S, Hussain S, Flores D, He Y, Shaw LN, Sun X.
PMID: 33893759
Environ Microbiol. 2021 Sep;23(9):5222-5238. doi: 10.1111/1462-2920.15529. Epub 2021 Apr 24.

Clostridioides difficile is a Gram-positive, spore-forming, toxin-producing anaerobe that can cause nosocomial antibiotic-associated intestinal disease. Although the production of toxin A (TcdA) and toxin B (TcdB) contribute to the main pathogenesis of C. difficile, the mechanism of TcdA and...

The Ontology of Biological and Clinical Statistics (OBCS)-based statistical method standardization and meta-analysis of host responses to yellow fever vaccines.

Quantitative biology (Beijing, China)

Zheng J, Li H, Liu Q, He Y.
PMID: 30034908
Quant Biol. 2017 Dec;5(4):291-301. Epub 2017 Nov 12.

BACKGROUND: The community-based Ontology of Biological and Clinical Statistics (OBCS) represents and standardizes biological and clinical data and statistical methods.METHODS: Both OBCS and the Vaccine Ontology (VO) were used to ontologically model various components and relations in a typical...

Genome Sequence of an Environmental Isolate of the Bacterial Pathogen Legionella pneumophila.

Genome announcements

Ma J, He Y, Hu B, Luo ZQ.
PMID: 23792742
Genome Announc. 2013 Jun 27;1(3). doi: 10.1128/genomeA.00320-13.

We report here the genomic sequence of Legionella pneumophila strain LPE509 from the water distribution system of a hospital in Shanghai, China. This is the first complete genome sequence of an environmental L. pneumophila isolate. Genomic analyses identified approximately...

Showing 1 to 12 of 19 entries