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Soluble mediators regulating immunity in early life.

Frontiers in immunology

Pettengill MA, van Haren SD, Levy O.
PMID: 25309541
Front Immunol. 2014 Sep 24;5:457. doi: 10.3389/fimmu.2014.00457. eCollection 2014.

Soluble factors in blood plasma have a substantial impact on both the innate and adaptive immune responses. The complement system, antibodies, and anti-microbial proteins and peptides can directly interact with potential pathogens, protecting against systemic infection. Levels of these...

Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage.

Frontiers in immunology

Pettengill MA, Levy O.
PMID: 27066009
Front Immunol. 2016 Mar 30;7:121. doi: 10.3389/fimmu.2016.00121. eCollection 2016.

BACKGROUND: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate, are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood may influence their function and has been incompletely characterized.METHODS: Mononuclear cells were...

Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization.

Frontiers in immunology

Borriello F, Pietrasanta C, Lai JCY, Walsh LM, Sharma P, O'Driscoll DN, Ramirez J, Brightman S, Pugni L, Mosca F, Burkhart DJ, Dowling DJ, Levy O.
PMID: 29312305
Front Immunol. 2017 Dec 12;8:1772. doi: 10.3389/fimmu.2017.01772. eCollection 2017.

Immunization is key to preventing infectious diseases, a leading cause of death early in life. However, due to age-specific immunity, vaccines often demonstrate reduced efficacy in newborns and young infants as compared to adults. Here, we combined

Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future.

Frontiers in pediatrics

Schüller SS, Kramer BW, Villamor E, Spittler A, Berger A, Levy O.
PMID: 30073156
Front Pediatr. 2018 Jul 19;6:199. doi: 10.3389/fped.2018.00199. eCollection 2018.

Despite continued advances in neonatal medicine, sepsis remains a leading cause of death worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates varies markedly from that in older children and adults, and distinct acute inflammatory...

Showing 1 to 4 of 4 entries