Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 20 entries
Sorted by: Best Match Show Resources per page
The janus head of T cell aging - autoimmunity and immunodeficiency.

Frontiers in immunology

Goronzy JJ, Li G, Yang Z, Weyand CM.
PMID: 23761790
Front Immunol. 2013 Jun 04;4:131. doi: 10.3389/fimmu.2013.00131. eCollection 2013.

Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence...

Cite
Goronzy JJ, Li G, Yang Z, et al. The janus head of T cell aging - autoimmunity and immunodeficiency. Front Immunol. 2013;4:131doi: 10.3389/fimmu.2013.00131.
Goronzy, J. J., Li, G., Yang, Z., & Weyand, C. M. (2013). The janus head of T cell aging - autoimmunity and immunodeficiency. Frontiers in immunology, 4131. https://doi.org/10.3389/fimmu.2013.00131
Goronzy, Jörg J, et al. "The janus head of T cell aging - autoimmunity and immunodeficiency." Frontiers in immunology vol. 4 (2013): 131. doi: https://doi.org/10.3389/fimmu.2013.00131
Goronzy JJ, Li G, Yang Z, Weyand CM. The janus head of T cell aging - autoimmunity and immunodeficiency. Front Immunol. 2013 Jun 04;4:131. doi: 10.3389/fimmu.2013.00131. eCollection 2013. PMID: 23761790; PMCID: PMC3671290.
Copy Download .nbib Format: NLM
Understanding T cell aging to improve anti-viral immunity.

Current opinion in virology

Zhang H, Weyand CM, Goronzy JJ, Gustafson CE.
PMID: 34688983
Curr Opin Virol. 2021 Dec;51:127-133. doi: 10.1016/j.coviro.2021.09.017. Epub 2021 Oct 21.

T cells are a critical component of the immune system and required for protection against viral and bacterial infections. However, the capacity of these cells to provide sufficient protection declines with age, leading to an increased susceptibility to and...

Cite
Zhang H, Weyand CM, Goronzy JJ, et al. Understanding T cell aging to improve anti-viral immunity. Curr Opin Virol. 2021;51:127-133doi: 10.1016/j.coviro.2021.09.017.
Zhang, H., Weyand, C. M., Goronzy, J. J., & Gustafson, C. E. (2021). Understanding T cell aging to improve anti-viral immunity. Current opinion in virology, 51127-133. https://doi.org/10.1016/j.coviro.2021.09.017
Zhang, Huimin, et al. "Understanding T cell aging to improve anti-viral immunity." Current opinion in virology vol. 51 (2021): 127-133. doi: https://doi.org/10.1016/j.coviro.2021.09.017
Zhang H, Weyand CM, Goronzy JJ, Gustafson CE. Understanding T cell aging to improve anti-viral immunity. Curr Opin Virol. 2021 Dec;51:127-133. doi: 10.1016/j.coviro.2021.09.017. Epub 2021 Oct 21. PMID: 34688983; PMCID: PMC8643327.
Copy Download .nbib Format: NLM
Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

Cite
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021;288(24):7123-7142doi: 10.1111/febs.15770.
Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021). Hallmarks of the aging T-cell system. The FEBS journal, 288(24), 7123-7142. https://doi.org/10.1111/febs.15770
Zhang, Huimin, et al. "Hallmarks of the aging T-cell system." The FEBS journal vol. 288,24 (2021): 7123-7142. doi: https://doi.org/10.1111/febs.15770
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03. PMID: 33590946; PMCID: PMC8364928.
Copy Download .nbib Format: NLM
Geographical variations in ocular and extra-ocular manifestations in Behçet's disease.

European journal of rheumatology

Shahram F, Mæhlen MT, Akhlaghi M, Davatchi F, Liao YJ, Weyand CM.
PMID: 31329543
Eur J Rheumatol. 2019 Jul 19;6(4):199-206. doi: 10.5152/eurjrheum.2019.18215. Print 2019 Oct.

OBJECTIVE: Behçet's disease (BD) is a rare vasculitis that results in multi-organ inflammatory disease. At-risk populations are most prevalent in the Middle East and East Asia. Clinical data on BD in Western countries, especially in the United States, are...

Cite
Shahram F, Mæhlen MT, Akhlaghi M, et al. Geographical variations in ocular and extra-ocular manifestations in Behçet's disease. Eur J Rheumatol. 2019;6(4):199-206doi: 10.5152/eurjrheum.2019.18215.
Shahram, F., Mæhlen, M. T., Akhlaghi, M., Davatchi, F., Liao, Y. J., & Weyand, C. M. (2019). Geographical variations in ocular and extra-ocular manifestations in Behçet's disease. European journal of rheumatology, 6(4), 199-206. https://doi.org/10.5152/eurjrheum.2019.18215
Shahram, Farhad, et al. "Geographical variations in ocular and extra-ocular manifestations in Behçet's disease." European journal of rheumatology vol. 6,4 (2019): 199-206. doi: https://doi.org/10.5152/eurjrheum.2019.18215
Shahram F, Mæhlen MT, Akhlaghi M, Davatchi F, Liao YJ, Weyand CM. Geographical variations in ocular and extra-ocular manifestations in Behçet's disease. Eur J Rheumatol. 2019 Jul 19;6(4):199-206. doi: 10.5152/eurjrheum.2019.18215. Print 2019 Oct. PMID: 31329543; PMCID: PMC6812895.
Copy Download .nbib Format: NLM
Metabolic Fitness of T Cells in Autoimmune Disease.

Immunometabolism

Wu B, Goronzy JJ, Weyand CM.
PMID: 32477606
Immunometabolism. 2020;2(2). doi: 10.20900/immunometab20200017. Epub 2020 Apr 22.

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are relatively common autoimmune diseases, often considered prototypic examples for how protective immunity switches to destructive immunity. The autoantigens recognized in RA and SLE are distinct, clinical manifestations are partially overlapping....

Cite
Wu B, Goronzy JJ, Weyand CM. Metabolic Fitness of T Cells in Autoimmune Disease. Immunometabolism. 2020;2(2)doi: 10.20900/immunometab20200017.
Wu, B., Goronzy, J. J., & Weyand, C. M. (2020). Metabolic Fitness of T Cells in Autoimmune Disease. Immunometabolism, 2(2), . https://doi.org/10.20900/immunometab20200017
Wu, Bowen, et al. "Metabolic Fitness of T Cells in Autoimmune Disease." Immunometabolism vol. 2,2 (2020). doi: https://doi.org/10.20900/immunometab20200017
Wu B, Goronzy JJ, Weyand CM. Metabolic Fitness of T Cells in Autoimmune Disease. Immunometabolism. 2020;2(2). doi: 10.20900/immunometab20200017. Epub 2020 Apr 22. PMID: 32477606; PMCID: PMC7261019.
Copy Download .nbib Format: NLM
Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

Cite
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021;288(24):7123-7142doi: 10.1111/febs.15770.
Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021). Hallmarks of the aging T-cell system. The FEBS journal, 288(24), 7123-7142. https://doi.org/10.1111/febs.15770
Zhang, Huimin, et al. "Hallmarks of the aging T-cell system." The FEBS journal vol. 288,24 (2021): 7123-7142. doi: https://doi.org/10.1111/febs.15770
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03. PMID: 33590946; PMCID: PMC8364928.
Copy Download .nbib Format: NLM
T cell-macrophage interactions and granuloma formation in vasculitis.

Frontiers in immunology

Hilhorst M, Shirai T, Berry G, Goronzy JJ, Weyand CM.
PMID: 25309534
Front Immunol. 2014 Sep 12;5:432. doi: 10.3389/fimmu.2014.00432. eCollection 2014.

Granuloma formation, bringing into close proximity highly activated macrophages and T cells, is a typical event in inflammatory blood vessel diseases, and is noted in the name of several of the vasculitides. It is not known whether specific properties...

Cite
Hilhorst M, Shirai T, Berry G, et al. T cell-macrophage interactions and granuloma formation in vasculitis. Front Immunol. 2014;5:432doi: 10.3389/fimmu.2014.00432.
Hilhorst, M., Shirai, T., Berry, G., Goronzy, J. J., & Weyand, C. M. (2014). T cell-macrophage interactions and granuloma formation in vasculitis. Frontiers in immunology, 5432. https://doi.org/10.3389/fimmu.2014.00432
Hilhorst, Marc, et al. "T cell-macrophage interactions and granuloma formation in vasculitis." Frontiers in immunology vol. 5 (2014): 432. doi: https://doi.org/10.3389/fimmu.2014.00432
Hilhorst M, Shirai T, Berry G, Goronzy JJ, Weyand CM. T cell-macrophage interactions and granuloma formation in vasculitis. Front Immunol. 2014 Sep 12;5:432. doi: 10.3389/fimmu.2014.00432. eCollection 2014. PMID: 25309534; PMCID: PMC4162471.
Copy Download .nbib Format: NLM
Finding Balance: T cell Regulatory Receptor Expression during Aging.

Aging and disease

Cavanagh MM, Qi Q, Weyand CM, Goronzy JJ.
PMID: 22396890
Aging Dis. 2011 Oct;2(5):398-413. Epub 2011 Oct 28.

Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of...

Cite
Cavanagh MM, Qi Q, Weyand CM, et al. Finding Balance: T cell Regulatory Receptor Expression during Aging. Aging Dis. 2011;2(5):398-413
Cavanagh, M. M., Qi, Q., Weyand, C. M., & Goronzy, J. J. (2011). Finding Balance: T cell Regulatory Receptor Expression during Aging. Aging and disease, 2(5), 398-413.
Cavanagh, Mary M, et al. "Finding Balance: T cell Regulatory Receptor Expression during Aging." Aging and disease vol. 2,5 (2011): 398-413.
Cavanagh MM, Qi Q, Weyand CM, Goronzy JJ. Finding Balance: T cell Regulatory Receptor Expression during Aging. Aging Dis. 2011 Oct;2(5):398-413. Epub 2011 Oct 28. PMID: 22396890; PMCID: PMC3295076.
Copy Download .nbib Format: NLM
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.

Nature immunology

Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM.
PMID: 34811544
Nat Immunol. 2021 Dec;22(12):1551-1562. doi: 10.1038/s41590-021-01065-2. Epub 2021 Nov 22.

Misdirected immunity gives rise to the autoimmune tissue inflammation of rheumatoid arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central pathogenic event. Mechanisms underlying the breakdown of self-tolerance are unclear, but T cells...

Cite
Wu B, Zhao TV, Jin K, et al. Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol. 2021;22(12):1551-1562doi: 10.1038/s41590-021-01065-2.
Wu, B., Zhao, T. V., Jin, K., Hu, Z., Abdel, M. P., Warrington, K. J., Goronzy, J. J., & Weyand, C. M. (2021). Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nature immunology, 22(12), 1551-1562. https://doi.org/10.1038/s41590-021-01065-2
Wu, Bowen, et al. "Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation." Nature immunology vol. 22,12 (2021): 1551-1562. doi: https://doi.org/10.1038/s41590-021-01065-2
Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM. Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol. 2021 Dec;22(12):1551-1562. doi: 10.1038/s41590-021-01065-2. Epub 2021 Nov 22. PMID: 34811544.
Copy Download .nbib Format: NLM
Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Feb 16; doi: 10.1111/febs.15770. Epub 2021 Feb 16.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

Cite
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021;doi: 10.1111/febs.15770.
Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021). Hallmarks of the aging T-cell system. The FEBS journal, . https://doi.org/10.1111/febs.15770
Zhang, Huimin, et al. "Hallmarks of the aging T-cell system." The FEBS journal vol. (2021). doi: https://doi.org/10.1111/febs.15770
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021 Feb 16; doi: 10.1111/febs.15770. Epub 2021 Feb 16. PMID: 33590946; PMCID: PMC8364928.
Copy Download .nbib Format: NLM
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

The Journal of clinical investigation

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG.
PMID: 27035819
J Clin Invest. 2016 Apr 01;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 01.

No abstract available.

Cite
Wu J, Saleh MA, Kirabo A, et al. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest. 2016;126(4):1607doi: 10.1172/JCI87425.
Wu, J., Saleh, M. A., Kirabo, A., Itani, H. A., Montaniel, K. R., Xiao, L., Chen, W., Mernaugh, R. L., Cai, H., Bernstein, K. E., Goronzy, J. J., Weyand, C. M., Curci, J. A., Barbaro, N. R., Moreno, H., Davies, S. S., Roberts, L. J., Madhur, M. S., & Harrison, D. G. (2016). Immune activation caused by vascular oxidation promotes fibrosis and hypertension. The Journal of clinical investigation, 126(4), 1607. https://doi.org/10.1172/JCI87425
Wu, Jing, et al. "Immune activation caused by vascular oxidation promotes fibrosis and hypertension." The Journal of clinical investigation vol. 126,4 (2016): 1607. doi: https://doi.org/10.1172/JCI87425
Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest. 2016 Apr 01;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 01. PMID: 27035819; PMCID: PMC4811163.
Copy Download .nbib Format: NLM
Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

Frontiers in immunology

Gustafson CE, Qi Q, Hutter-Saunders J, Gupta S, Jadhav R, Newell E, Maecker H, Weyand CM, Goronzy JJ.
PMID: 28659925
Front Immunol. 2017 Jun 14;8:692. doi: 10.3389/fimmu.2017.00692. eCollection 2017.

Aging is associated with an increased susceptibility to infection and a failure to control latent viruses thought to be driven, at least in part, by alterations in CD8 T cell function. The aging T cell repertoire is characterized by...

Cite
Gustafson CE, Qi Q, Hutter-Saunders J, et al. Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging. Front Immunol. 2017;8:692doi: 10.3389/fimmu.2017.00692.
Gustafson, C. E., Qi, Q., Hutter-Saunders, J., Gupta, S., Jadhav, R., Newell, E., Maecker, H., Weyand, C. M., & Goronzy, J. J. (2017). Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging. Frontiers in immunology, 8692. https://doi.org/10.3389/fimmu.2017.00692
Gustafson, Claire E, et al. "Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging." Frontiers in immunology vol. 8 (2017): 692. doi: https://doi.org/10.3389/fimmu.2017.00692
Gustafson CE, Qi Q, Hutter-Saunders J, Gupta S, Jadhav R, Newell E, Maecker H, Weyand CM, Goronzy JJ. Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging. Front Immunol. 2017 Jun 14;8:692. doi: 10.3389/fimmu.2017.00692. eCollection 2017. PMID: 28659925; PMCID: PMC5469909.
Copy Download .nbib Format: NLM
Showing 1 to 12 of 20 entries