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Showing 1 to 12 of 18 entries
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HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis.

Modern rheumatology

Takemura S, Toda Y, Goronzy JJ, Weyand CM, Ogawa R, Iida H.
PMID: 17028803
Mod Rheumatol. 2004;14(1):37-42. doi: 10.1007/s10165-003-0263-4.

This study investigated whether the HLA-DRB1 "susceptible allele" (SA) genotype is predictive for total knee arthroplasty (TKA) failure in patients with rheumatoid arthritis (RA). The results of 49 TKAs (30 RA patients) with an average follow-up of 7.9 years...

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Takemura S, Toda Y, Goronzy JJ, et al. HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis. Mod Rheumatol. 2004;14(1):37-42doi: 10.1007/s10165-003-0263-4.
Takemura, S., Toda, Y., Goronzy, J. J., Weyand, C. M., Ogawa, R., & Iida, H. (2004). HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis. Modern rheumatology, 14(1), 37-42. https://doi.org/10.1007/s10165-003-0263-4
Takemura, Seisuke, et al. "HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis." Modern rheumatology vol. 14,1 (2004): 37-42. doi: https://doi.org/10.1007/s10165-003-0263-4
Takemura S, Toda Y, Goronzy JJ, Weyand CM, Ogawa R, Iida H. HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis. Mod Rheumatol. 2004;14(1):37-42. doi: 10.1007/s10165-003-0263-4. PMID: 17028803.
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The janus head of T cell aging - autoimmunity and immunodeficiency.

Frontiers in immunology

Goronzy JJ, Li G, Yang Z, Weyand CM.
PMID: 23761790
Front Immunol. 2013 Jun 04;4:131. doi: 10.3389/fimmu.2013.00131. eCollection 2013.

Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence...

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Goronzy JJ, Li G, Yang Z, et al. The janus head of T cell aging - autoimmunity and immunodeficiency. Front Immunol. 2013;4:131doi: 10.3389/fimmu.2013.00131.
Goronzy, J. J., Li, G., Yang, Z., & Weyand, C. M. (2013). The janus head of T cell aging - autoimmunity and immunodeficiency. Frontiers in immunology, 4131. https://doi.org/10.3389/fimmu.2013.00131
Goronzy, Jörg J, et al. "The janus head of T cell aging - autoimmunity and immunodeficiency." Frontiers in immunology vol. 4 (2013): 131. doi: https://doi.org/10.3389/fimmu.2013.00131
Goronzy JJ, Li G, Yang Z, Weyand CM. The janus head of T cell aging - autoimmunity and immunodeficiency. Front Immunol. 2013 Jun 04;4:131. doi: 10.3389/fimmu.2013.00131. eCollection 2013. PMID: 23761790; PMCID: PMC3671290.
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Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

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Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021;288(24):7123-7142doi: 10.1111/febs.15770.
Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021). Hallmarks of the aging T-cell system. The FEBS journal, 288(24), 7123-7142. https://doi.org/10.1111/febs.15770
Zhang, Huimin, et al. "Hallmarks of the aging T-cell system." The FEBS journal vol. 288,24 (2021): 7123-7142. doi: https://doi.org/10.1111/febs.15770
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03. PMID: 33590946; PMCID: PMC8364928.
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Geographical variations in ocular and extra-ocular manifestations in Behçet's disease.

European journal of rheumatology

Shahram F, Mæhlen MT, Akhlaghi M, Davatchi F, Liao YJ, Weyand CM.
PMID: 31329543
Eur J Rheumatol. 2019 Jul 19;6(4):199-206. doi: 10.5152/eurjrheum.2019.18215. Print 2019 Oct.

OBJECTIVE: Behçet's disease (BD) is a rare vasculitis that results in multi-organ inflammatory disease. At-risk populations are most prevalent in the Middle East and East Asia. Clinical data on BD in Western countries, especially in the United States, are...

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Shahram F, Mæhlen MT, Akhlaghi M, et al. Geographical variations in ocular and extra-ocular manifestations in Behçet's disease. Eur J Rheumatol. 2019;6(4):199-206doi: 10.5152/eurjrheum.2019.18215.
Shahram, F., Mæhlen, M. T., Akhlaghi, M., Davatchi, F., Liao, Y. J., & Weyand, C. M. (2019). Geographical variations in ocular and extra-ocular manifestations in Behçet's disease. European journal of rheumatology, 6(4), 199-206. https://doi.org/10.5152/eurjrheum.2019.18215
Shahram, Farhad, et al. "Geographical variations in ocular and extra-ocular manifestations in Behçet's disease." European journal of rheumatology vol. 6,4 (2019): 199-206. doi: https://doi.org/10.5152/eurjrheum.2019.18215
Shahram F, Mæhlen MT, Akhlaghi M, Davatchi F, Liao YJ, Weyand CM. Geographical variations in ocular and extra-ocular manifestations in Behçet's disease. Eur J Rheumatol. 2019 Jul 19;6(4):199-206. doi: 10.5152/eurjrheum.2019.18215. Print 2019 Oct. PMID: 31329543; PMCID: PMC6812895.
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Metabolic Fitness of T Cells in Autoimmune Disease.

Immunometabolism

Wu B, Goronzy JJ, Weyand CM.
PMID: 32477606
Immunometabolism. 2020;2(2). doi: 10.20900/immunometab20200017. Epub 2020 Apr 22.

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are relatively common autoimmune diseases, often considered prototypic examples for how protective immunity switches to destructive immunity. The autoantigens recognized in RA and SLE are distinct, clinical manifestations are partially overlapping....

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Wu B, Goronzy JJ, Weyand CM. Metabolic Fitness of T Cells in Autoimmune Disease. Immunometabolism. 2020;2(2)doi: 10.20900/immunometab20200017.
Wu, B., Goronzy, J. J., & Weyand, C. M. (2020). Metabolic Fitness of T Cells in Autoimmune Disease. Immunometabolism, 2(2), . https://doi.org/10.20900/immunometab20200017
Wu, Bowen, et al. "Metabolic Fitness of T Cells in Autoimmune Disease." Immunometabolism vol. 2,2 (2020). doi: https://doi.org/10.20900/immunometab20200017
Wu B, Goronzy JJ, Weyand CM. Metabolic Fitness of T Cells in Autoimmune Disease. Immunometabolism. 2020;2(2). doi: 10.20900/immunometab20200017. Epub 2020 Apr 22. PMID: 32477606; PMCID: PMC7261019.
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Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

Cite
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021;288(24):7123-7142doi: 10.1111/febs.15770.
Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021). Hallmarks of the aging T-cell system. The FEBS journal, 288(24), 7123-7142. https://doi.org/10.1111/febs.15770
Zhang, Huimin, et al. "Hallmarks of the aging T-cell system." The FEBS journal vol. 288,24 (2021): 7123-7142. doi: https://doi.org/10.1111/febs.15770
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03. PMID: 33590946; PMCID: PMC8364928.
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T cell-macrophage interactions and granuloma formation in vasculitis.

Frontiers in immunology

Hilhorst M, Shirai T, Berry G, Goronzy JJ, Weyand CM.
PMID: 25309534
Front Immunol. 2014 Sep 12;5:432. doi: 10.3389/fimmu.2014.00432. eCollection 2014.

Granuloma formation, bringing into close proximity highly activated macrophages and T cells, is a typical event in inflammatory blood vessel diseases, and is noted in the name of several of the vasculitides. It is not known whether specific properties...

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Hilhorst M, Shirai T, Berry G, et al. T cell-macrophage interactions and granuloma formation in vasculitis. Front Immunol. 2014;5:432doi: 10.3389/fimmu.2014.00432.
Hilhorst, M., Shirai, T., Berry, G., Goronzy, J. J., & Weyand, C. M. (2014). T cell-macrophage interactions and granuloma formation in vasculitis. Frontiers in immunology, 5432. https://doi.org/10.3389/fimmu.2014.00432
Hilhorst, Marc, et al. "T cell-macrophage interactions and granuloma formation in vasculitis." Frontiers in immunology vol. 5 (2014): 432. doi: https://doi.org/10.3389/fimmu.2014.00432
Hilhorst M, Shirai T, Berry G, Goronzy JJ, Weyand CM. T cell-macrophage interactions and granuloma formation in vasculitis. Front Immunol. 2014 Sep 12;5:432. doi: 10.3389/fimmu.2014.00432. eCollection 2014. PMID: 25309534; PMCID: PMC4162471.
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Finding Balance: T cell Regulatory Receptor Expression during Aging.

Aging and disease

Cavanagh MM, Qi Q, Weyand CM, Goronzy JJ.
PMID: 22396890
Aging Dis. 2011 Oct;2(5):398-413. Epub 2011 Oct 28.

Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of...

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Cavanagh MM, Qi Q, Weyand CM, et al. Finding Balance: T cell Regulatory Receptor Expression during Aging. Aging Dis. 2011;2(5):398-413
Cavanagh, M. M., Qi, Q., Weyand, C. M., & Goronzy, J. J. (2011). Finding Balance: T cell Regulatory Receptor Expression during Aging. Aging and disease, 2(5), 398-413.
Cavanagh, Mary M, et al. "Finding Balance: T cell Regulatory Receptor Expression during Aging." Aging and disease vol. 2,5 (2011): 398-413.
Cavanagh MM, Qi Q, Weyand CM, Goronzy JJ. Finding Balance: T cell Regulatory Receptor Expression during Aging. Aging Dis. 2011 Oct;2(5):398-413. Epub 2011 Oct 28. PMID: 22396890; PMCID: PMC3295076.
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Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.

Nature immunology

Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM.
PMID: 34811544
Nat Immunol. 2021 Dec;22(12):1551-1562. doi: 10.1038/s41590-021-01065-2. Epub 2021 Nov 22.

Misdirected immunity gives rise to the autoimmune tissue inflammation of rheumatoid arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central pathogenic event. Mechanisms underlying the breakdown of self-tolerance are unclear, but T cells...

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Wu B, Zhao TV, Jin K, et al. Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol. 2021;22(12):1551-1562doi: 10.1038/s41590-021-01065-2.
Wu, B., Zhao, T. V., Jin, K., Hu, Z., Abdel, M. P., Warrington, K. J., Goronzy, J. J., & Weyand, C. M. (2021). Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nature immunology, 22(12), 1551-1562. https://doi.org/10.1038/s41590-021-01065-2
Wu, Bowen, et al. "Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation." Nature immunology vol. 22,12 (2021): 1551-1562. doi: https://doi.org/10.1038/s41590-021-01065-2
Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM. Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol. 2021 Dec;22(12):1551-1562. doi: 10.1038/s41590-021-01065-2. Epub 2021 Nov 22. PMID: 34811544.
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Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Feb 16; doi: 10.1111/febs.15770. Epub 2021 Feb 16.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

Cite
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021;doi: 10.1111/febs.15770.
Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021). Hallmarks of the aging T-cell system. The FEBS journal, . https://doi.org/10.1111/febs.15770
Zhang, Huimin, et al. "Hallmarks of the aging T-cell system." The FEBS journal vol. (2021). doi: https://doi.org/10.1111/febs.15770
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021 Feb 16; doi: 10.1111/febs.15770. Epub 2021 Feb 16. PMID: 33590946; PMCID: PMC8364928.
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Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

The Journal of clinical investigation

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG.
PMID: 27035819
J Clin Invest. 2016 Apr 01;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 01.

No abstract available.

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Wu J, Saleh MA, Kirabo A, et al. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest. 2016;126(4):1607doi: 10.1172/JCI87425.
Wu, J., Saleh, M. A., Kirabo, A., Itani, H. A., Montaniel, K. R., Xiao, L., Chen, W., Mernaugh, R. L., Cai, H., Bernstein, K. E., Goronzy, J. J., Weyand, C. M., Curci, J. A., Barbaro, N. R., Moreno, H., Davies, S. S., Roberts, L. J., Madhur, M. S., & Harrison, D. G. (2016). Immune activation caused by vascular oxidation promotes fibrosis and hypertension. The Journal of clinical investigation, 126(4), 1607. https://doi.org/10.1172/JCI87425
Wu, Jing, et al. "Immune activation caused by vascular oxidation promotes fibrosis and hypertension." The Journal of clinical investigation vol. 126,4 (2016): 1607. doi: https://doi.org/10.1172/JCI87425
Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest. 2016 Apr 01;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 01. PMID: 27035819; PMCID: PMC4811163.
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Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions.

International journal of clinical rheumatology

Hong J, Maron DJ, Shirai T, Weyand CM.
PMID: 27042216
Int J Clin Rheumtol. 2015 Oct;10(5):365-381. doi: 10.2217/ijr.15.33.

Atherosclerosis is a complex inflammatory disease involving aberrant immune and tissue healing responses, which begins with endothelial dysfunction and ends with plaque development, instability and rupture. The increased risk for coronary artery disease in patients with rheumatologic diseases highlights...

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Hong J, Maron DJ, Shirai T, et al. Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions. Int J Clin Rheumtol. 2015;10(5):365-381doi: 10.2217/ijr.15.33.
Hong, J., Maron, D. J., Shirai, T., & Weyand, C. M. (2015). Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions. International journal of clinical rheumatology, 10(5), 365-381. https://doi.org/10.2217/ijr.15.33
Hong, Jison, et al. "Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions." International journal of clinical rheumatology vol. 10,5 (2015): 365-381. doi: https://doi.org/10.2217/ijr.15.33
Hong J, Maron DJ, Shirai T, Weyand CM. Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions. Int J Clin Rheumtol. 2015 Oct;10(5):365-381. doi: 10.2217/ijr.15.33. PMID: 27042216; PMCID: PMC4814165.
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Showing 1 to 12 of 18 entries