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Showing 1 to 12 of 16 entries
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Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action.

Evidence-based complementary and alternative medicine : eCAM

Wu AH, He L, Long W, Zhou Q, Zhu S, Wang P, Fan S, Wang H.
PMID: 25821489
Evid Based Complement Alternat Med. 2015;2015:456305. doi: 10.1155/2015/456305. Epub 2015 Mar 02.

High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here...

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Wu AH, He L, Long W, et al. Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action. Evid Based Complement Alternat Med. 2015;2015:456305doi: 10.1155/2015/456305.
Wu, A. H., He, L., Long, W., Zhou, Q., Zhu, S., Wang, P., Fan, S., & Wang, H. (2015). Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action. Evidence-based complementary and alternative medicine : eCAM, 2015456305. https://doi.org/10.1155/2015/456305
Wu, Andrew H, et al. "Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 456305. doi: https://doi.org/10.1155/2015/456305
Wu AH, He L, Long W, Zhou Q, Zhu S, Wang P, Fan S, Wang H. Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action. Evid Based Complement Alternat Med. 2015;2015:456305. doi: 10.1155/2015/456305. Epub 2015 Mar 02. PMID: 25821489; PMCID: PMC4363608.
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Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

JCI insight

Yang H, Wang H, Levine YA, Gunasekaran MK, Wang Y, Addorisio M, Zhu S, Li W, Li J, de Kleijn DP, Olofsson PS, Warren HS, He M, Al-Abed Y, Roth J, Antoine DJ, Chavan SS, Andersson U, Tracey KJ.
PMID: 27294203
JCI Insight. 2016;1(7). doi: 10.1172/jci.insight.85375. Epub 2016 May 19.

Secreted by activated cells or passively released by damaged cells, extracellular HMGB1 is a prototypical damage-associated molecular pattern (DAMP) inflammatory mediator. During the course of developing extracorporeal approaches to treating injury and infection, we inadvertently discovered that haptoglobin, the...

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Yang H, Wang H, Levine YA, et al. Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes. JCI Insight. 2016;1(7)doi: 10.1172/jci.insight.85375.
Yang, H., Wang, H., Levine, Y. A., Gunasekaran, M. K., Wang, Y., Addorisio, M., Zhu, S., Li, W., Li, J., de Kleijn, D. P., Olofsson, P. S., Warren, H. S., He, M., Al-Abed, Y., Roth, J., Antoine, D. J., Chavan, S. S., Andersson, U., & Tracey, K. J. (2016). Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes. JCI insight, 1(7), . https://doi.org/10.1172/jci.insight.85375
Yang, Huan, et al. "Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes." JCI insight vol. 1,7 (2016). doi: https://doi.org/10.1172/jci.insight.85375
Yang H, Wang H, Levine YA, Gunasekaran MK, Wang Y, Addorisio M, Zhu S, Li W, Li J, de Kleijn DP, Olofsson PS, Warren HS, He M, Al-Abed Y, Roth J, Antoine DJ, Chavan SS, Andersson U, Tracey KJ. Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes. JCI Insight. 2016;1(7). doi: 10.1172/jci.insight.85375. Epub 2016 May 19. PMID: 27294203; PMCID: PMC4902170.
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Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis.

Frontiers in microbiology

Li Y, Xiao H, Dong J, Luo D, Wang H, Zhang S, Zhu T, Zhu C, Cui M, Fan S.
PMID: 32670255
Front Microbiol. 2020 Jun 26;11:1450. doi: 10.3389/fmicb.2020.01450. eCollection 2020.

Radiation therapy is a cornerstone of modern management methods for malignancies but is accompanied by diverse side effects. In the present study, we showed that food additives such as polysorbate 80 (P80) exacerbate irradiation-induced gastrointestinal (GI) tract toxicity. A...

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Li Y, Xiao H, Dong J, et al. Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis. Front Microbiol. 2020;11:1450doi: 10.3389/fmicb.2020.01450.
Li, Y., Xiao, H., Dong, J., Luo, D., Wang, H., Zhang, S., Zhu, T., Zhu, C., Cui, M., & Fan, S. (2020). Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis. Frontiers in microbiology, 111450. https://doi.org/10.3389/fmicb.2020.01450
Li, Yuan, et al. "Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis." Frontiers in microbiology vol. 11 (2020): 1450. doi: https://doi.org/10.3389/fmicb.2020.01450
Li Y, Xiao H, Dong J, Luo D, Wang H, Zhang S, Zhu T, Zhu C, Cui M, Fan S. Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis. Front Microbiol. 2020 Jun 26;11:1450. doi: 10.3389/fmicb.2020.01450. eCollection 2020. PMID: 32670255; PMCID: PMC7332576.
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Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction.

Journal of leukocyte biology

Qiang X, Zhu S, Li J, Chen W, Yang H, Wang P, Tracey KJ, Wang H.
PMID: 33759207
J Leukoc Biol. 2022 Jan;111(1):261-267. doi: 10.1002/JLB.3COVCRA0920-628RR. Epub 2021 Mar 24.

A severe acute respiratory syndrome (SARS)-like coronavirus 2 (SARS-CoV-2) has recently caused a pandemic COVID-19 disease that infected approximately 94 million and killed more than 2,000,000 people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of...

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Qiang X, Zhu S, Li J, et al. Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction. J Leukoc Biol. 2021;111(1):261-267doi: 10.1002/JLB.3COVCRA0920-628RR.
Qiang, X., Zhu, S., Li, J., Chen, W., Yang, H., Wang, P., Tracey, K. J., & Wang, H. (2022). Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction. Journal of leukocyte biology, 111(1), 261-267. https://doi.org/10.1002/JLB.3COVCRA0920-628RR
Qiang, Xiaoling, et al. "Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction." Journal of leukocyte biology vol. 111,1 (2022): 261-267. doi: https://doi.org/10.1002/JLB.3COVCRA0920-628RR
Qiang X, Zhu S, Li J, Chen W, Yang H, Wang P, Tracey KJ, Wang H. Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction. J Leukoc Biol. 2022 Jan;111(1):261-267. doi: 10.1002/JLB.3COVCRA0920-628RR. Epub 2021 Mar 24. PMID: 33759207; PMCID: PMC8251270.
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Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1.

International journal of clinical and experimental medicine

Zhu S, Li W, Li J, Sama AE, Wang H.
PMID: 19079688
Int J Clin Exp Med. 2008;1(1):64-75. Epub 2008 Jan 20.

Sepsis refers to a systemic inflammatory response syndrome resulting from a microbial infection, which kills > 225,000 people annually in the U.S. alone. The high mortality of sepsis is partly mediated by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially...

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Zhu S, Li W, Li J, et al. Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1. Int J Clin Exp Med. 2008;1(1):64-75
Zhu, S., Li, W., Li, J., Sama, A. E., & Wang, H. (2008). Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1. International journal of clinical and experimental medicine, 1(1), 64-75.
Zhu, Shu, et al. "Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1." International journal of clinical and experimental medicine vol. 1,1 (2008): 64-75.
Zhu S, Li W, Li J, Sama AE, Wang H. Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1. Int J Clin Exp Med. 2008;1(1):64-75. Epub 2008 Jan 20. PMID: 19079688; PMCID: PMC2596337.
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Ionizing Radiation Induces HMGB1 Cytoplasmic Translocation and Extracellular Release.

Guo ji fang she yi xue he yi xue za zhi = International journal of radiation medicine and nuclear medicine

Wang L, He L, Bao G, He X, Fan S, Wang H.
PMID: 27331198
Guo Ji Fang She Yi Xue He Yi Xue Za Zhi. 2016 Mar;40(2):91-99. Epub 2016 Apr 15.

OBJECTIVE: A nucleosomal protein, HMGB1, can be secreted by activated immune cells or passively released by dying cells, thereby amplifying rigorous inflammatory responses. In this study we aimed to test the possibility that ionizing radiation similarly induces cytoplasmic HMGB1...

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Wang L, He L, Bao G, et al. Ionizing Radiation Induces HMGB1 Cytoplasmic Translocation and Extracellular Release. Guo Ji Fang She Yi Xue He Yi Xue Za Zhi. 2016;40(2):91-99
Wang, L., He, L., Bao, G., He, X., Fan, S., & Wang, H. (2016). Ionizing Radiation Induces HMGB1 Cytoplasmic Translocation and Extracellular Release. Guo ji fang she yi xue he yi xue za zhi = International journal of radiation medicine and nuclear medicine, 40(2), 91-99.
Wang, Lili, et al. "Ionizing Radiation Induces HMGB1 Cytoplasmic Translocation and Extracellular Release." Guo ji fang she yi xue he yi xue za zhi = International journal of radiation medicine and nuclear medicine vol. 40,2 (2016): 91-99.
Wang L, He L, Bao G, He X, Fan S, Wang H. Ionizing Radiation Induces HMGB1 Cytoplasmic Translocation and Extracellular Release. Guo Ji Fang She Yi Xue He Yi Xue Za Zhi. 2016 Mar;40(2):91-99. Epub 2016 Apr 15. PMID: 27331198; PMCID: PMC4911189.
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HMGB1 released from nociceptors mediates inflammation.

Proceedings of the National Academy of Sciences of the United States of America

Yang H, Zeng Q, Silverman HA, Gunasekaran M, George SJ, Devarajan A, Addorisio ME, Li J, Tsaava T, Shah V, Billiar TR, Wang H, Brines M, Andersson U, Pavlov VA, Chang EH, Chavan SS, Tracey KJ.
PMID: 34385304
Proc Natl Acad Sci U S A. 2021 Aug 17;118(33). doi: 10.1073/pnas.2102034118.

Inflammation, the body's primary defensive response system to injury and infection, is triggered by molecular signatures of microbes and tissue injury. These molecules also stimulate specialized sensory neurons, termed nociceptors. Activation of nociceptors mediates inflammation through antidromic release of...

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Yang H, Zeng Q, Silverman HA, et al. HMGB1 released from nociceptors mediates inflammation. Proc Natl Acad Sci U S A. 2021;118(33)doi: 10.1073/pnas.2102034118.
Yang, H., Zeng, Q., Silverman, H. A., Gunasekaran, M., George, S. J., Devarajan, A., Addorisio, M. E., Li, J., Tsaava, T., Shah, V., Billiar, T. R., Wang, H., Brines, M., Andersson, U., Pavlov, V. A., Chang, E. H., Chavan, S. S., & Tracey, K. J. (2021). HMGB1 released from nociceptors mediates inflammation. Proceedings of the National Academy of Sciences of the United States of America, 118(33), . https://doi.org/10.1073/pnas.2102034118
Yang, Huan, et al. "HMGB1 released from nociceptors mediates inflammation." Proceedings of the National Academy of Sciences of the United States of America vol. 118,33 (2021). doi: https://doi.org/10.1073/pnas.2102034118
Yang H, Zeng Q, Silverman HA, Gunasekaran M, George SJ, Devarajan A, Addorisio ME, Li J, Tsaava T, Shah V, Billiar TR, Wang H, Brines M, Andersson U, Pavlov VA, Chang EH, Chavan SS, Tracey KJ. HMGB1 released from nociceptors mediates inflammation. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33). doi: 10.1073/pnas.2102034118. PMID: 34385304; PMCID: PMC8379951.
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Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction.

Journal of leukocyte biology

Qiang X, Zhu S, Li J, Chen W, Yang H, Wang P, Tracey KJ, Wang H.
PMID: 33759207
J Leukoc Biol. 2022 Jan;111(1):261-267. doi: 10.1002/JLB.3COVCRA0920-628RR. Epub 2021 Mar 24.

A severe acute respiratory syndrome (SARS)-like coronavirus 2 (SARS-CoV-2) has recently caused a pandemic COVID-19 disease that infected approximately 94 million and killed more than 2,000,000 people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of...

Cite
Qiang X, Zhu S, Li J, et al. Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction. J Leukoc Biol. 2021;111(1):261-267doi: 10.1002/JLB.3COVCRA0920-628RR.
Qiang, X., Zhu, S., Li, J., Chen, W., Yang, H., Wang, P., Tracey, K. J., & Wang, H. (2022). Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction. Journal of leukocyte biology, 111(1), 261-267. https://doi.org/10.1002/JLB.3COVCRA0920-628RR
Qiang, Xiaoling, et al. "Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction." Journal of leukocyte biology vol. 111,1 (2022): 261-267. doi: https://doi.org/10.1002/JLB.3COVCRA0920-628RR
Qiang X, Zhu S, Li J, Chen W, Yang H, Wang P, Tracey KJ, Wang H. Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction. J Leukoc Biol. 2022 Jan;111(1):261-267. doi: 10.1002/JLB.3COVCRA0920-628RR. Epub 2021 Mar 24. PMID: 33759207; PMCID: PMC8251270.
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It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis.

Evidence-based complementary and alternative medicine : eCAM

Zhu S, Li W, Li J, Jundoria A, Sama AE, Wang H.
PMID: 23193422
Evid Based Complement Alternat Med. 2012;2012:498467. doi: 10.1155/2012/498467. Epub 2012 Oct 24.

Mung bean (Vigna Radiata) has been traditionally used in China both as nutritional food and herbal medicine against a number of inflammatory conditions since the 1050s. A nucleosomal protein, HMGB1, has recently been established as a late mediator of...

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Zhu S, Li W, Li J, et al. It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis. Evid Based Complement Alternat Med. 2012;2012:498467doi: 10.1155/2012/498467.
Zhu, S., Li, W., Li, J., Jundoria, A., Sama, A. E., & Wang, H. (2012). It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis. Evidence-based complementary and alternative medicine : eCAM, 2012498467. https://doi.org/10.1155/2012/498467
Zhu, Shu, et al. "It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis." Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 498467. doi: https://doi.org/10.1155/2012/498467
Zhu S, Li W, Li J, Jundoria A, Sama AE, Wang H. It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis. Evid Based Complement Alternat Med. 2012;2012:498467. doi: 10.1155/2012/498467. Epub 2012 Oct 24. PMID: 23193422; PMCID: PMC3489087.
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Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2.

Molecular medicine (Cambridge, Mass.)

Zhang Z, Deng W, Kang R, Xie M, Billiar T, Wang H, Cao L, Tang D.
PMID: 26982513
Mol Med. 2016 Sep;22:162-172. doi: 10.2119/molmed.2015.00250. Epub 2016 Mar 09.

Sepsis is characterized by dysregulated systemic inflammation with release of early (for example, interleukin (IL)-1β) and late (for example, HMGB1) proinflammatory mediators from macrophages. Plumbagin, a medicinal plant-derived naphthoquinone, has been reported to exhibit antiinflammatory activity, but the underling...

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Zhang Z, Deng W, Kang R, et al. Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2. Mol Med. 2016;22:162-172doi: 10.2119/molmed.2015.00250.
Zhang, Z., Deng, W., Kang, R., Xie, M., Billiar, T., Wang, H., Cao, L., & Tang, D. (2016). Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2. Molecular medicine (Cambridge, Mass.), 22162-172. https://doi.org/10.2119/molmed.2015.00250
Zhang, Zhaoxia, et al. "Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2." Molecular medicine (Cambridge, Mass.) vol. 22 (2016): 162-172. doi: https://doi.org/10.2119/molmed.2015.00250
Zhang Z, Deng W, Kang R, Xie M, Billiar T, Wang H, Cao L, Tang D. Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2. Mol Med. 2016 Sep;22:162-172. doi: 10.2119/molmed.2015.00250. Epub 2016 Mar 09. PMID: 26982513; PMCID: PMC5004715.
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Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cui M, Xiao H, Li Y, Zhang S, Dong J, Wang B, Zhu C, Jiang M, Zhu T, He J, Wang H, Fan S.
PMID: 31728280
Adv Sci (Weinh). 2019 Aug 29;6(21):1901048. doi: 10.1002/advs.201901048. eCollection 2019 Nov 06.

Accidental or iatrogenic ionizing radiation exposure precipitates acute and chronic radiation injuries. The traditional paradigm of mitigating radiotherapy-associated adverse side effects has ignored the gender-specific dimorphism of patients' divergent responses. Here, the effects of sexual dimorphism on curative efficiencies...

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Cui M, Xiao H, Li Y, et al. Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries. Adv Sci (Weinh). 2019;6(21):1901048doi: 10.1002/advs.201901048.
Cui, M., Xiao, H., Li, Y., Zhang, S., Dong, J., Wang, B., Zhu, C., Jiang, M., Zhu, T., He, J., Wang, H., & Fan, S. (2019). Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(21), 1901048. https://doi.org/10.1002/advs.201901048
Cui, Ming, et al. "Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 6,21 (2019): 1901048. doi: https://doi.org/10.1002/advs.201901048
Cui M, Xiao H, Li Y, Zhang S, Dong J, Wang B, Zhu C, Jiang M, Zhu T, He J, Wang H, Fan S. Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries. Adv Sci (Weinh). 2019 Aug 29;6(21):1901048. doi: 10.1002/advs.201901048. eCollection 2019 Nov 06. PMID: 31728280; PMCID: PMC6839645.
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Time to Develop Therapeutic Antibodies Against Harmless Proteins Colluding with Sepsis Mediators?.

ImmunoTargets and therapy

Li J, Bao G, Wang H.
PMID: 33117741
Immunotargets Ther. 2020 Oct 05;9:157-166. doi: 10.2147/ITT.S262605. eCollection 2020.

Sepsis refers to a systemic inflammatory response syndrome resulting from microbial infections, and is partly attributable to dysregulated inflammation and associated immunosuppression. A ubiquitous nuclear protein, HMGB1, is secreted by activated leukocytes to orchestrate inflammatory responses during early stages...

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Li J, Bao G, Wang H. Time to Develop Therapeutic Antibodies Against Harmless Proteins Colluding with Sepsis Mediators?. Immunotargets Ther. 2020;9:157-166doi: 10.2147/ITT.S262605.
Li, J., Bao, G., & Wang, H. (2020). Time to Develop Therapeutic Antibodies Against Harmless Proteins Colluding with Sepsis Mediators?. ImmunoTargets and therapy, 9157-166. https://doi.org/10.2147/ITT.S262605
Li, Jianhua, et al. "Time to Develop Therapeutic Antibodies Against Harmless Proteins Colluding with Sepsis Mediators?." ImmunoTargets and therapy vol. 9 (2020): 157-166. doi: https://doi.org/10.2147/ITT.S262605
Li J, Bao G, Wang H. Time to Develop Therapeutic Antibodies Against Harmless Proteins Colluding with Sepsis Mediators?. Immunotargets Ther. 2020 Oct 05;9:157-166. doi: 10.2147/ITT.S262605. eCollection 2020. PMID: 33117741; PMCID: PMC7547129.
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