Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 7 of 7 entries
Sorted by: Best Match Show Resources per page
Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.

Translational lung cancer research

Qian D, Liu H, Zhao L, Wang X, Luo S, Moorman PG, Patz EF, Su L, Shen S, Christiani DC, Wei Q.
PMID: 32676321
Transl Lung Cancer Res. 2020 Jun;9(3):575-586. doi: 10.21037/tlcr-19-318.

BACKGROUND: Both antibody-dependent cellular cytotoxicity and phagocytosis activate innate immunity, and the Fc gamma receptor (FCGR)-mediated phagocytosis is an integral part of the process. We assessed associations between single-nucleotide polymorphisms (SNPs) in FCGR-related genes and survival of patients with...

Novel genetic variants of .

American journal of cancer research

Liu L, Liu H, Luo S, Patz EF, Glass C, Su L, Lin L, Christiani DC, Wei Q.
PMID: 32905494
Am J Cancer Res. 2020 Aug 01;10(8):2603-2616. eCollection 2020.

Although lymphangiogenesis is a vital step in lung cancer metastasis, the association between lymphangiogenesis and non-small cell lung cancer (NSCLC) survival remains unclear. Since single-nucleotide polymorphisms (SNPs) have been reported to predict NSCLC survival, we investigated associations between SNPs...

Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival.

Cancer informatics

Wang Z, Choi S, Lee J, Huang YT, Chen F, Zhao Y, Lin X, Neuberg D, Kim J, Christiani DC.
PMID: 25657573
Cancer Inform. 2015 Jan 27;14:1-9. doi: 10.4137/CIN.S13976. eCollection 2015.

Mutations in the mtDNA genome have long been suspected to play an important role in cancer. Although most cancer cells harbor mtDNA mutations, the question of whether such mutations are associated with clinical prognosis of lung cancer remains unclear....

Comparing measures of model selection for penalized splines in Cox models.

Computational statistics & data analysis

Malloy EJ, Spiegelman D, Eisen EA.
PMID: 20161167
Comput Stat Data Anal. 2009 May 15;53(7):2605-2616. doi: 10.1016/j.csda.2008.12.008.

This article presents an application and a simulation study of model fit criteria for selecting the optimal degree of smoothness for penalized splines in Cox models. The criteria considered were the Akaike information criterion, the corrected AIC, two formulations...

TEGS-CN: A Statistical Method for Pathway Analysis of Genome-wide Copy Number Profile.

Cancer informatics

Huang YT, Hsu T, Christiani DC.
PMID: 25452685
Cancer Inform. 2014 Oct 15;13:15-23. doi: 10.4137/CIN.S13978. eCollection 2014.

The effects of copy number alterations make up a significant part of the tumor genome profile, but pathway analyses of these alterations are still not well established. We proposed a novel method to analyze multiple copy numbers of genes...

Discovery of common SNPs in the miR-205/200 family-regulated epithelial to mesenchymal transition pathway and their association with risk for non-small cell lung cancer.

International journal of molecular epidemiology and genetics

Leng S, Bernauer AM, Zhai R, Tellez CS, Su L, Burki EA, Picchi MA, Stidley CA, Crowell RE, Christiani DC, Belinsky SA.
PMID: 21686129
Int J Mol Epidemiol Genet. 2011;2(2):145-55. Epub 2011 Apr 01.

The activation of the epithelial-to-mesenchymal transition (EMT) program is an important step for tumor initiation, invasion, and metastasis in solid tumors, including lung cancer. The purpose of this study was to identify the sequence variants in the miR-205/200 family-regulated...

Genetic variants of .

American journal of cancer research

Tang D, Liu H, Zhao Y, Qian D, Luo S, Patz EF, Su L, Shen S, ChristianI DC, Gao W, Wei Q.
PMID: 32905523
Am J Cancer Res. 2020 Aug 01;10(8):2582-2595. eCollection 2020.

The nod-like receptor protein 3 (NLRP3) is one of the most characterized inflammasomes, and its genetic variation and functional dysregulation are involved in pathogenesis of several cancers. To systematically evaluate the role of NLRP3 in predicting outcomes of patients...

Showing 1 to 7 of 7 entries