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Peripheral tissue homing receptor control of naïve, effector, and memory CD8 T cell localization in lymphoid and non-lymphoid tissues.

Frontiers in immunology

Brinkman CC, Peske JD, Engelhard VH.
PMID: 23966998
Front Immunol. 2013 Aug 19;4:241. doi: 10.3389/fimmu.2013.00241. eCollection 2013.

T cell activation induces homing receptors that bind ligands on peripheral tissue vasculature, programing movement to sites of infection and injury. There are three major types of CD8 effector T cells based on homing receptor expression, which arise in...

The contributions of mass spectrometry to understanding of immune recognition by T lymphocytes.

International journal of mass spectrometry

Engelhard VH.
PMID: 18167512
Int J Mass Spectrom. 2007 Jan 01;259(1):32-39. doi: 10.1016/j.ijms.2006.08.009.

Over the last 15 years, the ability of mass spectrometry to analyze complex peptide mixtures and identify individual species has provided unprecedented insights into the repertoire of peptide antigens displayed by MHC molecules and recognized by T lymphocytes. These...

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts.

Cell reports

Rodriguez AB, Peske JD, Woods AN, Leick KM, Mauldin IS, Meneveau MO, Young SJ, Lindsay RS, Melssen MM, Cyranowski S, Parriott G, Conaway MR, Fu YX, Slingluff CL, Engelhard VH.
PMID: 34289373
Cell Rep. 2021 Jul 20;36(3):109422. doi: 10.1016/j.celrep.2021.109422.

Tumor-associated tertiary lymphoid structures (TA-TLS) are associated with enhanced patient survival and responsiveness to cancer therapies, but the mechanisms underlying their development are unknown. We show here that TA-TLS development in murine melanoma is orchestrated by cancer-associated fibroblasts (CAF)...

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