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DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial.

International journal of molecular epidemiology and genetics

Doherty JA, Sakoda LC, Loomis MM, Barnett MJ, Julianto L, Thornquist MD, Neuhouser ML, Weiss NS, Goodman GE, Chen C.
PMID: 23565320
Int J Mol Epidemiol Genet. 2013;4(1):11-34. Epub 2013 Mar 18.

Many carcinogens in tobacco smoke cause DNA damage, and some of that damage can be mitigated by the actions of DNA repair enzymes. In a case-control study nested within the Beta-Carotene and Retinol Efficacy Trial, a randomized chemoprevention trial...

Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers.

International journal of molecular epidemiology and genetics

Sakoda LC, Loomis MM, Doherty JA, Julianto L, Barnett MJ, Neuhouser ML, Thornquist MD, Weiss NS, Goodman GE, Chen C.
PMID: 22493747
Int J Mol Epidemiol Genet. 2012;3(1):1-17. Epub 2012 Feb 05.

Since nucleotide excision repair (NER) is primarily responsible for detecting and removing bulky DNA lesions induced by tobacco smoke in the respiratory tract, single nucleotide polymorphisms (SNPs) in NER protein-encoding genes may influence lung cancer risk, particularly in smokers....

Showing 1 to 2 of 2 entries