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Manic fringe inhibits tumor growth by suppressing Notch3 degradation in lung cancer.

American journal of cancer research

Yi F, Amarasinghe B, Dang TP.
PMID: 24224126
Am J Cancer Res. 2013 Nov 01;3(5):490-9. eCollection 2013.

Notch signaling plays an essential role in development as well as cancer. We have previously shown that Notch3 is important for lung cancer growth and survival. Notch receptors are activated through the interaction with their ligands, resulting in proteolytic...

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