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The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.

Therapeutic advances in hematology

Tosello V, Ferrando AA.
PMID: 23730497
Ther Adv Hematol. 2013 Jun;4(3):199-210. doi: 10.1177/2040620712471368.

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is characterized by aberrant activation of NOTCH1 in over 60% of T-ALL cases. The high prevalence of activating NOTCH1 mutations highlights the critical role of NOTCH signaling in the pathogenesis of this disease and...

Showing 1 to 1 of 1 entries