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Showing 1 to 5 of 5 entries
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The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.

Cellular and molecular gastroenterology and hepatology

Wang F, Zhang Y, Shen J, Yang B, Dai W, Yan J, Maimouni S, Daguplo HQ, Coppola S, Gao Y, Wang Y, Du Z, Peng K, Liu H, Zhang Q, Tang F, Wang P, Gao S, Wang Y, Ding WX, Guo G, Wang F, Zong WX.
PMID: 33482392
Cell Mol Gastroenterol Hepatol. 2021;11(5):1369-1385. doi: 10.1016/j.jcmgh.2021.01.007. Epub 2021 Jan 19.

BACKGROUND AND AIMS: TRIM21 is a ubiquitin E3 ligase that is implicated in numerous biological processes including immune response, cell metabolism, redox homeostasis, and cancer development. We recently reported that TRIM21 can negatively regulate the p62-Keap1-Nrf2 antioxidant pathway by...

The Pleiotropic Effects of Glutamine Metabolism in Cancer.

Cancers

Bott AJ, Maimouni S, Zong WX.
PMID: 31167399
Cancers (Basel). 2019 Jun 04;11(6). doi: 10.3390/cancers11060770.

Metabolic programs are known to be altered in cancers arising from various tissues. Malignant transformation can alter signaling pathways related to metabolism and increase the demand for both energy and biomass for the proliferating cancerous cells. This scenario is...

Non-apoptotic routes to defeat cancer.

Oncoimmunology

Guerriero JL, Ditsworth D, Zong WX.
PMID: 22720222
Oncoimmunology. 2012 Jan 01;1(1):94-96. doi: 10.4161/onci.1.1.17885.

The mechanism of tumor cell death after treatment with DNA alkylating agents in vivo previously remained largely unknown. We demonstrate that tumor regression after chemotherapy occurs via sporadic necrosis and relies on activation of innate immunity in a manner...

Consensus guidelines for the detection of immunogenic cell death.

Oncoimmunology

Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, Cirone M, Colombo MI, Cremer I, Demaria S, Dini L, Eliopoulos AG, Faggioni A, Formenti SC, Fučíková J, Gabriele L, Gaipl US, Galon J, Garg A, Ghiringhelli F, Giese NA, Guo ZS, Hemminki A, Herrmann M, Hodge JW, Holdenrieder S, Honeychurch J, Hu HM, Huang X, Illidge TM, Kono K, Korbelik M, Krysko DV, Loi S, Lowenstein PR, Lugli E, Ma Y, Madeo F, Manfredi AA, Martins I, Mavilio D, Menger L, Merendino N, Michaud M, Mignot G, Mossman KL, Multhoff G, Oehler R, Palombo F, Panaretakis T, Pol J, Proietti E, Ricci JE, Riganti C, Rovere-Querini P, Rubartelli A, Sistigu A, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Sukkurwala AQ, Tartour E, Thorburn A, Thorne SH, Vandenabeele P, Velotti F, Workenhe ST, Yang H, Zong WX, Zitvogel L, Kroemer G, Galluzzi L.
PMID: 25941621
Oncoimmunology. 2014 Dec 13;3(9):e955691. doi: 10.4161/21624011.2014.955691. eCollection 2014 Oct.

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the...

Spectrophotometric Determination of Glutamine Synthetase Activity in Cultured Cells.

Bio-protocol

Peng IC, Bott AJ, Zong WX.
PMID: 31380466
Bio Protoc. 2016 Oct 05;6(19). doi: 10.21769/BioProtoc.1959.

Glutamine synthetase (GS), which catalyzes the conversion of glutamate and ammonia to glutamine, is widely distributed in animal tissues and cell culture lines. The importance of this enzyme is suggested by the fact that glutamine, the product of GS-catalyzed...

Showing 1 to 5 of 5 entries