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RIP3 finds partners in crime.

Cell

Chan FK, Baehrecke EH.
PMID: 22265396
Cell. 2012 Jan 20;148(1):17-8. doi: 10.1016/j.cell.2011.12.020.

Programmed necrosis has long been recognized as a crucial component of animal development; however, the signaling pathway beyond the protein kinases RIP1 and RIP3 remains largely unknown. Sun et al. and Wang et al. now identify critical factors downstream...

Current questions and possible controversies in autophagy.

Cell death discovery

Lindqvist LM, Simon AK, Baehrecke EH.
PMID: 26682061
Cell Death Discov. 2015;1. doi: 10.1038/cddiscovery.2015.36. Epub 2015 Nov 09.

Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of...

Autophagy, cell death, and cancer.

Molecular & cellular oncology

Lin L, Baehrecke EH.
PMID: 27308466
Mol Cell Oncol. 2015 Jan 26;2(3):e985913. doi: 10.4161/23723556.2014.985913. eCollection 2015.

Autophagy is an evolutionarily conserved intracellular catabolic process that is used by all cells to degrade dysfunctional or unnecessary cytoplasmic components through delivery to the lysosome. Increasing evidence reveals that autophagic dysfunction is associated with human diseases, such as...

Showing 1 to 3 of 3 entries