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Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing.

NPJ breast cancer

Southey MC, Dowty JG, Riaz M, Steen JA, Renault AL, Tucker K, Kirk J, James P, Winship I, Pachter N, Poplawski N, Grist S, Park DJ, Pope BJ, Mahmood K, Hammet F, Mahmoodi M, Tsimiklis H, Theys D, Rewse A, Willis A, Morrow A, Speechly C, Harris R, Sebra R, Schadt E, Lacaze P, McNeil JJ, Giles GG, Milne RL, Hopper JL, Nguyen-Dumont T.
PMID: 34887416
NPJ Breast Cancer. 2021 Dec 09;7(1):153. doi: 10.1038/s41523-021-00360-3.

Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing are urgently required. Most prior research has been based on women selected for high-risk features and more data is needed to make inference about...

Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk.

JNCI cancer spectrum

Kehm RD, MacInnis RJ, John EM, Liao Y, Kurian AW, Genkinger JM, Knight JA, Colonna SV, Chung WK, Milne R, Zeinomar N, Dite GS, Southey MC, Giles GG, McLachlan SA, Whitaker KD, Friedlander ML, Weideman PC, Glendon G, Nesci S, Phillips KA, Andrulis IL, Buys SS, Daly MB, Hopper JL, Terry MB.
PMID: 34950851
JNCI Cancer Spectr. 2021 Dec 08;5(6):pkab090. doi: 10.1093/jncics/pkab090. eCollection 2021 Dec.

BACKGROUND: Recreational physical activity (RPA) is associated with improved survival after breast cancer (BC) in average-risk women, but evidence is limited for women who are at increased familial risk because of a BC family history or METHODS: We estimated...

Comparing 5-Year and Lifetime Risks of Breast Cancer using the Prospective Family Study Cohort.

Journal of the National Cancer Institute

MacInnis RJ, Knight JA, Chung WK, Milne RL, Whittemore AS, Buchsbaum R, Liao Y, Zeinomar N, Dite GS, Southey MC, Goldgar D, Giles GG, Kurian AW, Andrulis IL, John EM, Daly MB, Buys SS, Phillips KA, Hopper JL, Terry MB.
PMID: 33301022
J Natl Cancer Inst. 2021 Jun 01;113(6):785-791. doi: 10.1093/jnci/djaa178.

BACKGROUND: Clinical guidelines often use predicted lifetime risk from birth to define criteria for making decisions regarding breast cancer screening rather than thresholds based on absolute 5-year risk from current age.METHODS: We used the Prospective Family Cohort Study of...

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