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Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors.

JCI insight

Elias KM, Emori MM, Westerling T, Long H, Budina-Kolomets A, Li F, MacDuffie E, Davis MR, Holman A, Lawney B, Freedman ML, Quackenbush J, Brown M, Drapkin R.
PMID: 27617304
JCI Insight. 2016 Aug 18;1(13). doi: 10.1172/jci.insight.87988.

Regulation of lineage-restricted transcription factors has been shown to influence malignant transformation in several types of cancer. Whether similar mechanisms are involved in ovarian cancer pathogenesis is unknown. PAX8 is a nuclear transcription factor that controls the embryologic development...

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Elias KM, Emori MM, Westerling T, et al. Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors. JCI Insight. 2016;1(13)doi: 10.1172/jci.insight.87988.
Elias, K. M., Emori, M. M., Westerling, T., Long, H., Budina-Kolomets, A., Li, F., MacDuffie, E., Davis, M. R., Holman, A., Lawney, B., Freedman, M. L., Quackenbush, J., Brown, M., & Drapkin, R. (2016). Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors. JCI insight, 1(13), . https://doi.org/10.1172/jci.insight.87988
Elias, Kevin M, et al. "Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors." JCI insight vol. 1,13 (2016). doi: https://doi.org/10.1172/jci.insight.87988
Elias KM, Emori MM, Westerling T, Long H, Budina-Kolomets A, Li F, MacDuffie E, Davis MR, Holman A, Lawney B, Freedman ML, Quackenbush J, Brown M, Drapkin R. Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors. JCI Insight. 2016 Aug 18;1(13). doi: 10.1172/jci.insight.87988. PMID: 27617304; PMCID: PMC5017158.
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Androgen receptor and MYC equilibration centralizes on developmental super-enhancer.

Nature communications

Guo H, Wu Y, Nouri M, Spisak S, Russo JW, Sowalsky AG, Pomerantz MM, Wei Z, Korthauer K, Seo JH, Wang L, Arai S, Freedman ML, He HH, Chen S, Balk SP.
PMID: 34911936
Nat Commun. 2021 Dec 15;12(1):7308. doi: 10.1038/s41467-021-27077-y.

Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of multiple genes including MYC, and supraphysiological androgen is effective in some patients. Here, we show that this repression is independent of AR chromatin binding and driven by...

Cite
Guo H, Wu Y, Nouri M, et al. Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nat Commun. 2021;12(1):7308doi: 10.1038/s41467-021-27077-y.
Guo, H., Wu, Y., Nouri, M., Spisak, S., Russo, J. W., Sowalsky, A. G., Pomerantz, M. M., Wei, Z., Korthauer, K., Seo, J. H., Wang, L., Arai, S., Freedman, M. L., He, H. H., Chen, S., & Balk, S. P. (2021). Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nature communications, 12(1), 7308. https://doi.org/10.1038/s41467-021-27077-y
Guo, Haiyang, et al. "Androgen receptor and MYC equilibration centralizes on developmental super-enhancer." Nature communications vol. 12,1 (2021): 7308. doi: https://doi.org/10.1038/s41467-021-27077-y
Guo H, Wu Y, Nouri M, Spisak S, Russo JW, Sowalsky AG, Pomerantz MM, Wei Z, Korthauer K, Seo JH, Wang L, Arai S, Freedman ML, He HH, Chen S, Balk SP. Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nat Commun. 2021 Dec 15;12(1):7308. doi: 10.1038/s41467-021-27077-y. PMID: 34911936; PMCID: PMC8674345.
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Exonic variants undergoing allele-specific selection in cancers.

BMC medical genomics

Li Q, Zeng Y, Wang J, Fang H, Guo J, Yu L, Zhong T, Xu C, Freedman M, LaFramboise T.
PMID: 34059054
BMC Med Genomics. 2021 May 31;14(1):142. doi: 10.1186/s12920-021-00984-1.

BACKGROUND: Allelic imbalance (AI) in tumors is caused by chromosomal and sub-chromosomal gains and losses.RESULTS: We evaluated AI at 109,086 germline exonic SNP loci in four cancer types, and identified a set of SNPs that demonstrate strong tumor allele...

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Li Q, Zeng Y, Wang J, et al. Exonic variants undergoing allele-specific selection in cancers. BMC Med Genomics. 2021;14(1):142doi: 10.1186/s12920-021-00984-1.
Li, Q., Zeng, Y., Wang, J., Fang, H., Guo, J., Yu, L., Zhong, T., Xu, C., Freedman, M., & LaFramboise, T. (2021). Exonic variants undergoing allele-specific selection in cancers. BMC medical genomics, 14(1), 142. https://doi.org/10.1186/s12920-021-00984-1
Li, Qiyuan, et al. "Exonic variants undergoing allele-specific selection in cancers." BMC medical genomics vol. 14,1 (2021): 142. doi: https://doi.org/10.1186/s12920-021-00984-1
Li Q, Zeng Y, Wang J, Fang H, Guo J, Yu L, Zhong T, Xu C, Freedman M, LaFramboise T. Exonic variants undergoing allele-specific selection in cancers. BMC Med Genomics. 2021 May 31;14(1):142. doi: 10.1186/s12920-021-00984-1. PMID: 34059054; PMCID: PMC8166126.
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Androgen receptor and MYC equilibration centralizes on developmental super-enhancer.

Nature communications

Guo H, Wu Y, Nouri M, Spisak S, Russo JW, Sowalsky AG, Pomerantz MM, Wei Z, Korthauer K, Seo JH, Wang L, Arai S, Freedman ML, He HH, Chen S, Balk SP.
PMID: 34911936
Nat Commun. 2021 Dec 15;12(1):7308. doi: 10.1038/s41467-021-27077-y.

Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of multiple genes including MYC, and supraphysiological androgen is effective in some patients. Here, we show that this repression is independent of AR chromatin binding and driven by...

Cite
Guo H, Wu Y, Nouri M, et al. Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nat Commun. 2021;12(1):7308doi: 10.1038/s41467-021-27077-y.
Guo, H., Wu, Y., Nouri, M., Spisak, S., Russo, J. W., Sowalsky, A. G., Pomerantz, M. M., Wei, Z., Korthauer, K., Seo, J. H., Wang, L., Arai, S., Freedman, M. L., He, H. H., Chen, S., & Balk, S. P. (2021). Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nature communications, 12(1), 7308. https://doi.org/10.1038/s41467-021-27077-y
Guo, Haiyang, et al. "Androgen receptor and MYC equilibration centralizes on developmental super-enhancer." Nature communications vol. 12,1 (2021): 7308. doi: https://doi.org/10.1038/s41467-021-27077-y
Guo H, Wu Y, Nouri M, Spisak S, Russo JW, Sowalsky AG, Pomerantz MM, Wei Z, Korthauer K, Seo JH, Wang L, Arai S, Freedman ML, He HH, Chen S, Balk SP. Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nat Commun. 2021 Dec 15;12(1):7308. doi: 10.1038/s41467-021-27077-y. PMID: 34911936.
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CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity.

Nature cancer

Watt AC, Cejas P, DeCristo MJ, Metzger-Filho O, Lam EYN, Qiu X, BrinJones H, Kesten N, Coulson R, Font-Tello A, Lim K, Vadhi R, Daniels VW, Montero J, Taing L, Meyer CA, Gilan O, Bell CC, Korthauer KD, Giambartolomei C, Pasaniuc B, Seo JH, Freedman ML, Ma C, Ellis MJ, Krop I, Winer E, Letai A, Brown M, Dawson MA, Long HW, Zhao JJ, Goel S.
PMID: 33997789
Nat Cancer. 2021 Jan;2(1):34-48. doi: 10.1038/s43018-020-00135-y. Epub 2020 Nov 09.

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert other effects, influencing cancer cell immunogenicity, apoptotic responses, and differentiation. Using cell-based and...

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Watt AC, Cejas P, DeCristo MJ, et al. CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity. Nat Cancer. 2020;2(1):34-48doi: 10.1038/s43018-020-00135-y.
Watt, A. C., Cejas, P., DeCristo, M. J., Metzger-Filho, O., Lam, E. Y. N., Qiu, X., BrinJones, H., Kesten, N., Coulson, R., Font-Tello, A., Lim, K., Vadhi, R., Daniels, V. W., Montero, J., Taing, L., Meyer, C. A., Gilan, O., Bell, C. C., Korthauer, K. D., Giambartolomei, C., Pasaniuc, B., Seo, J. H., Freedman, M. L., Ma, C., Ellis, M. J., Krop, I., Winer, E., Letai, A., Brown, M., Dawson, M. A., Long, H. W., Zhao, J. J., & Goel, S. (2021). CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity. Nature cancer, 2(1), 34-48. https://doi.org/10.1038/s43018-020-00135-y
Watt, April C, et al. "CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity." Nature cancer vol. 2,1 (2021): 34-48. doi: https://doi.org/10.1038/s43018-020-00135-y
Watt AC, Cejas P, DeCristo MJ, Metzger-Filho O, Lam EYN, Qiu X, BrinJones H, Kesten N, Coulson R, Font-Tello A, Lim K, Vadhi R, Daniels VW, Montero J, Taing L, Meyer CA, Gilan O, Bell CC, Korthauer KD, Giambartolomei C, Pasaniuc B, Seo JH, Freedman ML, Ma C, Ellis MJ, Krop I, Winer E, Letai A, Brown M, Dawson MA, Long HW, Zhao JJ, Goel S. CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity. Nat Cancer. 2021 Jan;2(1):34-48. doi: 10.1038/s43018-020-00135-y. Epub 2020 Nov 09. PMID: 33997789; PMCID: PMC8115221.
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Androgen receptor and MYC equilibration centralizes on developmental super-enhancer.

Nature communications

Guo H, Wu Y, Nouri M, Spisak S, Russo JW, Sowalsky AG, Pomerantz MM, Wei Z, Korthauer K, Seo JH, Wang L, Arai S, Freedman ML, He HH, Chen S, Balk SP.
PMID: 34911936
Nat Commun. 2021 Dec 15;12(1):7308. doi: 10.1038/s41467-021-27077-y.

Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of multiple genes including MYC, and supraphysiological androgen is effective in some patients. Here, we show that this repression is independent of AR chromatin binding and driven by...

Cite
Guo H, Wu Y, Nouri M, et al. Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nat Commun. 2021;12(1):7308doi: 10.1038/s41467-021-27077-y.
Guo, H., Wu, Y., Nouri, M., Spisak, S., Russo, J. W., Sowalsky, A. G., Pomerantz, M. M., Wei, Z., Korthauer, K., Seo, J. H., Wang, L., Arai, S., Freedman, M. L., He, H. H., Chen, S., & Balk, S. P. (2021). Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nature communications, 12(1), 7308. https://doi.org/10.1038/s41467-021-27077-y
Guo, Haiyang, et al. "Androgen receptor and MYC equilibration centralizes on developmental super-enhancer." Nature communications vol. 12,1 (2021): 7308. doi: https://doi.org/10.1038/s41467-021-27077-y
Guo H, Wu Y, Nouri M, Spisak S, Russo JW, Sowalsky AG, Pomerantz MM, Wei Z, Korthauer K, Seo JH, Wang L, Arai S, Freedman ML, He HH, Chen S, Balk SP. Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nat Commun. 2021 Dec 15;12(1):7308. doi: 10.1038/s41467-021-27077-y. PMID: 34911936; PMCID: PMC8674345.
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Showing 1 to 6 of 6 entries