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Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice.

Substance abuse : research and treatment

Lefever TW, Marusich JA, Thomas BF, Barrus DG, Peiper NC, Kevin RC, Wiley JL.
PMID: 28469427
Subst Abuse. 2017 Apr 07;11:1178221817701739. doi: 10.1177/1178221817701739. eCollection 2017.

Smoking is the most common route of administration for cannabis; however, vaping cannabis extracts and synthetic cannabinoids ("fake marijuana") in electronic cigarette devices has become increasingly popular. Yet, most animal models used to investigate biological mechanisms underlying cannabis use...

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Lefever TW, Marusich JA, Thomas BF, et al. Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice. Subst Abuse. 2017;11:1178221817701739doi: 10.1177/1178221817701739.
Lefever, T. W., Marusich, J. A., Thomas, B. F., Barrus, D. G., Peiper, N. C., Kevin, R. C., & Wiley, J. L. (2017). Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice. Substance abuse : research and treatment, 111178221817701739. https://doi.org/10.1177/1178221817701739
Lefever, Timothy W, et al. "Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice." Substance abuse : research and treatment vol. 11 (2017): 1178221817701739. doi: https://doi.org/10.1177/1178221817701739
Lefever TW, Marusich JA, Thomas BF, Barrus DG, Peiper NC, Kevin RC, Wiley JL. Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice. Subst Abuse. 2017 Apr 07;11:1178221817701739. doi: 10.1177/1178221817701739. eCollection 2017. PMID: 28469427; PMCID: PMC5398321.
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Prediction and Prevention of Prescription Drug Abuse: Role of Preclinical Assessment of Substance Abuse Liability.

Methods report (RTI Press)

Marusich JA, Lefever TW, Novak SP, Blough BE, Wiley JL.
PMID: 24008590
Methods Rep RTI Press. 2013 Jul;1-14. doi: 10.3768/rtipress.2013.op.0014.1307.

In 2011, the prevalence of prescription drug abuse exceeded that of any other illicit drug except marijuana. Consequently, efforts to curtail abuse of new medications should begin during the drug development process, where abuse liability can be identified and...

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Marusich JA, Lefever TW, Novak SP, et al. Prediction and Prevention of Prescription Drug Abuse: Role of Preclinical Assessment of Substance Abuse Liability. Methods Rep RTI Press. 2013;1-14doi: 10.3768/rtipress.2013.op.0014.1307.
Marusich, J. A., Lefever, T. W., Novak, S. P., Blough, B. E., & Wiley, J. L. (2013). Prediction and Prevention of Prescription Drug Abuse: Role of Preclinical Assessment of Substance Abuse Liability. Methods report (RTI Press), 1-14. https://doi.org/10.3768/rtipress.2013.op.0014.1307
Marusich, Julie A, et al. "Prediction and Prevention of Prescription Drug Abuse: Role of Preclinical Assessment of Substance Abuse Liability." Methods report (RTI Press) vol. (2013): 1-14. doi: https://doi.org/10.3768/rtipress.2013.op.0014.1307
Marusich JA, Lefever TW, Novak SP, Blough BE, Wiley JL. Prediction and Prevention of Prescription Drug Abuse: Role of Preclinical Assessment of Substance Abuse Liability. Methods Rep RTI Press. 2013 Jul;1-14. doi: 10.3768/rtipress.2013.op.0014.1307. PMID: 24008590; PMCID: PMC3759972.
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Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures.

Forensic toxicology

Kevin RC, Kovach AL, Lefever TW, Gamage TF, Wiley JL, McGregor IS, Thomas BF.
PMID: 30705707
Forensic Toxicol. 2019 Jan;37(1):17-26. doi: 10.1007/s11419-018-0430-0. Epub 2018 Jun 28.

PURPOSE: The use of novel synthetic cannabinoids as intoxicants continues in spite of associated health risks. These compounds are typically smoked or vaporized, but many synthetic cannabinoids contain thermally labile chemical moieties. This study investigated the thermal stability six...

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Kevin RC, Kovach AL, Lefever TW, et al. Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures. Forensic Toxicol. 2018;37(1):17-26doi: 10.1007/s11419-018-0430-0.
Kevin, R. C., Kovach, A. L., Lefever, T. W., Gamage, T. F., Wiley, J. L., McGregor, I. S., & Thomas, B. F. (2019). Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures. Forensic toxicology, 37(1), 17-26. https://doi.org/10.1007/s11419-018-0430-0
Kevin, Richard C, et al. "Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures." Forensic toxicology vol. 37,1 (2019): 17-26. doi: https://doi.org/10.1007/s11419-018-0430-0
Kevin RC, Kovach AL, Lefever TW, Gamage TF, Wiley JL, McGregor IS, Thomas BF. Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures. Forensic Toxicol. 2019 Jan;37(1):17-26. doi: 10.1007/s11419-018-0430-0. Epub 2018 Jun 28. PMID: 30705707; PMCID: PMC6349387.
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In vitro and in vivo pharmacokinetics and metabolism of synthetic cannabinoids CUMYL-PICA and 5F-CUMYL-PICA.

Forensic toxicology

Kevin RC, Lefever TW, Snyder RW, Patel PR, Fennell TR, Wiley JL, McGregor IS, Thomas BF.
PMID: 28824730
Forensic Toxicol. 2017;35(2):333-347. doi: 10.1007/s11419-017-0361-1. Epub 2017 Mar 10.

CUMYL-PICA [1-pentyl-

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Kevin RC, Lefever TW, Snyder RW, et al. In vitro and in vivo pharmacokinetics and metabolism of synthetic cannabinoids CUMYL-PICA and 5F-CUMYL-PICA. Forensic Toxicol. 2017;35(2):333-347doi: 10.1007/s11419-017-0361-1.
Kevin, R. C., Lefever, T. W., Snyder, R. W., Patel, P. R., Fennell, T. R., Wiley, J. L., McGregor, I. S., & Thomas, B. F. (2017). In vitro and in vivo pharmacokinetics and metabolism of synthetic cannabinoids CUMYL-PICA and 5F-CUMYL-PICA. Forensic toxicology, 35(2), 333-347. https://doi.org/10.1007/s11419-017-0361-1
Kevin, Richard C, et al. "In vitro and in vivo pharmacokinetics and metabolism of synthetic cannabinoids CUMYL-PICA and 5F-CUMYL-PICA." Forensic toxicology vol. 35,2 (2017): 333-347. doi: https://doi.org/10.1007/s11419-017-0361-1
Kevin RC, Lefever TW, Snyder RW, Patel PR, Fennell TR, Wiley JL, McGregor IS, Thomas BF. In vitro and in vivo pharmacokinetics and metabolism of synthetic cannabinoids CUMYL-PICA and 5F-CUMYL-PICA. Forensic Toxicol. 2017;35(2):333-347. doi: 10.1007/s11419-017-0361-1. Epub 2017 Mar 10. PMID: 28824730; PMCID: PMC5519669.
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Ligand Binding Sensitivity of the Extracellular Loop Two of the Cannabinoid Receptor 1.

Drug development research

Bertalovitz AC, Ahn KH, Kendall DA.
PMID: 21170298
Drug Dev Res. 2010 Nov 01;71(7):404-411. doi: 10.1002/ddr.20388.

The cannabinoid receptor one (CB1) is a class A G-protein-coupled receptor thought to bind ligands primarily within its helical bundle. Evidence suggests, however, that the extracellular domain may also play a role. We have previously shown that the C-terminus...

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Bertalovitz AC, Ahn KH, Kendall DA. Ligand Binding Sensitivity of the Extracellular Loop Two of the Cannabinoid Receptor 1. Drug Dev Res. 2010;71(7):404-411doi: 10.1002/ddr.20388.
Bertalovitz, A. C., Ahn, K. H., & Kendall, D. A. (2010). Ligand Binding Sensitivity of the Extracellular Loop Two of the Cannabinoid Receptor 1. Drug development research, 71(7), 404-411. https://doi.org/10.1002/ddr.20388
Bertalovitz, Alexander C, et al. "Ligand Binding Sensitivity of the Extracellular Loop Two of the Cannabinoid Receptor 1." Drug development research vol. 71,7 (2010): 404-411. doi: https://doi.org/10.1002/ddr.20388
Bertalovitz AC, Ahn KH, Kendall DA. Ligand Binding Sensitivity of the Extracellular Loop Two of the Cannabinoid Receptor 1. Drug Dev Res. 2010 Nov 01;71(7):404-411. doi: 10.1002/ddr.20388. PMID: 21170298; PMCID: PMC3003262.
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Tasty THC: Promises and Challenges of Cannabis Edibles.

Methods report (RTI Press)

Barrus DG, Capogrossi KL, Cates SC, Gourdet CK, Peiper NC, Novak SP, Lefever TW, Wiley JL.
PMID: 28127591
Methods Rep RTI Press. 2016 Nov;2016. doi: 10.3768/rtipress.2016.op.0035.1611.

Food products containing cannabis extract (edibles) have emerged as a popular and lucrative facet of the legalized market for both recreational and medicinal cannabis. The many formulations of cannabis extracts used in edibles present a unique regulatory challenge for...

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Barrus DG, Capogrossi KL, Cates SC, et al. Tasty THC: Promises and Challenges of Cannabis Edibles. Methods Rep RTI Press. 2016;2016doi: 10.3768/rtipress.2016.op.0035.1611.
Barrus, D. G., Capogrossi, K. L., Cates, S. C., Gourdet, C. K., Peiper, N. C., Novak, S. P., Lefever, T. W., & Wiley, J. L. (2016). Tasty THC: Promises and Challenges of Cannabis Edibles. Methods report (RTI Press), 2016. https://doi.org/10.3768/rtipress.2016.op.0035.1611
Barrus, Daniel G, et al. "Tasty THC: Promises and Challenges of Cannabis Edibles." Methods report (RTI Press) vol. 2016 (2016). doi: https://doi.org/10.3768/rtipress.2016.op.0035.1611
Barrus DG, Capogrossi KL, Cates SC, Gourdet CK, Peiper NC, Novak SP, Lefever TW, Wiley JL. Tasty THC: Promises and Challenges of Cannabis Edibles. Methods Rep RTI Press. 2016 Nov;2016. doi: 10.3768/rtipress.2016.op.0035.1611. PMID: 28127591; PMCID: PMC5260817.
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Hijacking of Basic Research: The Case of Synthetic Cannabinoids.

Methods report (RTI Press)

Wiley JL, Marusich JA, Huffman JW, Balster RL, Thomas BF.
PMID: 23397508
Methods Rep RTI Press. 2011 Nov;2011. doi: 10.3768/rtipress.2011.op.0007.1111.

Gathering and communicating knowledge are important aspects of the scientific endeavor. Yet presentation of data in public forums such as scientific meetings and publications makes it available not only to scientists, but also to others who may have different...

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Wiley JL, Marusich JA, Huffman JW, et al. Hijacking of Basic Research: The Case of Synthetic Cannabinoids. Methods Rep RTI Press. 2011;2011doi: 10.3768/rtipress.2011.op.0007.1111.
Wiley, J. L., Marusich, J. A., Huffman, J. W., Balster, R. L., & Thomas, B. F. (2011). Hijacking of Basic Research: The Case of Synthetic Cannabinoids. Methods report (RTI Press), 2011. https://doi.org/10.3768/rtipress.2011.op.0007.1111
Wiley, Jenny L, et al. "Hijacking of Basic Research: The Case of Synthetic Cannabinoids." Methods report (RTI Press) vol. 2011 (2011). doi: https://doi.org/10.3768/rtipress.2011.op.0007.1111
Wiley JL, Marusich JA, Huffman JW, Balster RL, Thomas BF. Hijacking of Basic Research: The Case of Synthetic Cannabinoids. Methods Rep RTI Press. 2011 Nov;2011. doi: 10.3768/rtipress.2011.op.0007.1111. PMID: 23397508; PMCID: PMC3567606.
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Sex, species and age: Effects of rodent demographics on the pharmacology of ∆.

Progress in neuro-psychopharmacology & biological psychiatry

Wiley JL, Barrus DG, Farquhar CE, Lefever TW, Gamage TF.
PMID: 32810571
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 02;106:110064. doi: 10.1016/j.pnpbp.2020.110064. Epub 2020 Aug 15.

Cannabis edibles are becoming more common in an increasingly diverse population of users, and the impact of first pass metabolism on cannabis's pharmacological profile across age and sex is not well understood. The present study examined the impact of...

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Wiley JL, Barrus DG, Farquhar CE, et al. Sex, species and age: Effects of rodent demographics on the pharmacology of ∆. Prog Neuropsychopharmacol Biol Psychiatry. 2020;106:110064doi: 10.1016/j.pnpbp.2020.110064.
Wiley, J. L., Barrus, D. G., Farquhar, C. E., Lefever, T. W., & Gamage, T. F. (2021). Sex, species and age: Effects of rodent demographics on the pharmacology of ∆. Progress in neuro-psychopharmacology & biological psychiatry, 106110064. https://doi.org/10.1016/j.pnpbp.2020.110064
Wiley, Jenny L, et al. "Sex, species and age: Effects of rodent demographics on the pharmacology of ∆." Progress in neuro-psychopharmacology & biological psychiatry vol. 106 (2021): 110064. doi: https://doi.org/10.1016/j.pnpbp.2020.110064
Wiley JL, Barrus DG, Farquhar CE, Lefever TW, Gamage TF. Sex, species and age: Effects of rodent demographics on the pharmacology of ∆. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 02;106:110064. doi: 10.1016/j.pnpbp.2020.110064. Epub 2020 Aug 15. PMID: 32810571; PMCID: PMC7750258.
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Showing 1 to 8 of 8 entries