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Converging vulnerability factors for compulsive food and drug use.

Neuropharmacology

Serafine KM, O'Dell LE, Zorrilla EP.
PMID: 33862029
Neuropharmacology. 2021 Sep 15;196:108556. doi: 10.1016/j.neuropharm.2021.108556. Epub 2021 Apr 20.

Highly palatable foods and substance of abuse have intersecting neurobiological, metabolic and behavioral effects relevant for understanding vulnerability to conditions related to food (e.g., obesity, binge eating disorder) and drug (e.g., substance use disorder) misuse. Here, we review data...

Behavioral, Biochemical, and Molecular Indices of Stress are Enhanced in Female Versus Male Rats Experiencing Nicotine Withdrawal.

Frontiers in psychiatry

Torres OV, Gentil LG, Natividad LA, Carcoba LM, O'Dell LE.
PMID: 23730292
Front Psychiatry. 2013 May 20;4:38. doi: 10.3389/fpsyt.2013.00038. eCollection 2013.

Stress is a major factor that promotes tobacco use and relapse during withdrawal. Although women are more vulnerable to tobacco use than men, the manner in which stress contributes to tobacco use in women versus men is unclear. Thus,...

Amino acid systems in the interpeduncular nucleus are altered in a sex-dependent manner during nicotine withdrawal.

Journal of neuroscience research

Carcoba LM, Uribe KP, Ortegon S, Mendez IA, DeBiasi M, O'Dell LE.
PMID: 33751631
J Neurosci Res. 2021 Mar 22; doi: 10.1002/jnr.24826. Epub 2021 Mar 22.

Prior work in male rodents established that the medial habenula-interpeduncular nucleus (MHb-IPN) pathway modulates nicotine withdrawal. Specifically, withdrawal severity has been closely associated with inhibitory tone in the IPN via interneurons that release γ-aminobutyric acid (GABA). Inhibitory tone in...

The emergence of insulin resistance following a chronic high-fat diet regimen coincides with an increase in the reinforcing effects of nicotine in a sex-dependent manner.

Neuropharmacology

Cruz B, Ortegon S, Giner P, Matos-Ocasio F, Rodriguez-Crespo A, Uribe KP, Galindo KI, Serafine KM, Nazarian A, O'Dell LE.
PMID: 34571112
Neuropharmacology. 2021 Dec 01;200:108787. doi: 10.1016/j.neuropharm.2021.108787. Epub 2021 Sep 24.

The present study assessed the sex-dependent effects of insulin resistance on the reinforcing effects of nicotine. Female and male rats received a chronic high-fat diet (HFD) or regular diet (RD) for 8 weeks. A subset of rats then received...

Showing 1 to 4 of 4 entries