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Showing 1 to 11 of 11 entries
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Genes for Good: Engaging the Public in Genetics Research via Social Media.

American journal of human genetics

Brieger K, Zajac GJM, Pandit A, Foerster JR, Li KW, Annis AC, Schmidt EM, Clark CP, McMorrow K, Zhou W, Yang J, Kwong AM, Boughton AP, Wu J, Scheller C, Parikh T, de la Vega A, Brazel DM, Frieser M, Rea-Sandin G, Fritsche LG, Vrieze SI, Abecasis GR.
PMID: 31374205
Am J Hum Genet. 2019 Aug 01;105(2):441-442. doi: 10.1016/j.ajhg.2019.07.009.

No abstract available.

Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood.

Addiction (Abingdon, England)

Deak JD, Clark DA, Liu M, Schaefer JD, Jang SK, Durbin CE, Iacono WG, McGue M, Vrieze S, Hicks BM.
PMID: 34590376
Addiction. 2021 Sep 29; doi: 10.1111/add.15697. Epub 2021 Sep 29.

BACKGROUND AND AIMS: Molecular genetic studies of alcohol and nicotine use have identified many genome-wide association study (GWAS) loci. We measured associations between drinking and smoking polygenic scores (PGS) and trajectories of alcohol and nicotine use outcomes from late...

Using multivariate endophenotypes to identify psychophysiological mechanisms associated with polygenic scores for substance use, schizophrenia, and education attainment.

Psychological medicine

Harper J, Liu M, Malone SM, McGue M, Iacono WG, Vrieze SI.
PMID: 33731234
Psychol Med. 2021 Mar 18;1-11. doi: 10.1017/S0033291721000763. Epub 2021 Mar 18.

BACKGROUND: To better characterize brain-based mechanisms of polygenic liability for psychopathology and psychological traits, we extended our previous report (Liu et al. Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci. Psychological Medicine, 2017), focused solely on schizophrenia,...

Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries.

Genetics

Kwong AM, Blackwell TW, LeFaive J, de Andrade M, Barnard J, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Cade BE, Chasman DI, Chen H, Conomos MP, Cupples LA, Ellinor PT, Eng C, Gao Y, Guo X, Irvin MR, Kelly TN, Kim W, Kooperberg C, Lubitz SA, Mak ACY, Manichaikul AW, Mathias RA, Montasser ME, Montgomery CG, Musani S, Palmer ND, Peloso GM, Qiao D, Reiner AP, Roden DM, Shoemaker MB, Smith JA, Smith NL, Su JL, Tiwari HK, Weeks DE, Weiss ST, Scott LJ, Smith AV, Abecasis GR, Boehnke M, Kang HM.
PMID: 33720349
Genetics. 2021 May 17;218(1). doi: 10.1093/genetics/iyab044.

Traditional Hardy-Weinberg equilibrium (HWE) tests (the χ2 test and the exact test) have long been used as a metric for evaluating genotype quality, as technical artifacts leading to incorrect genotype calls often can be identified as deviations from HWE....

Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood.

Addiction (Abingdon, England)

Deak JD, Clark DA, Liu M, Schaefer JD, Jang SK, Durbin CE, Iacono WG, McGue M, Vrieze S, Hicks BM.
PMID: 34590376
Addiction. 2021 Sep 29; doi: 10.1111/add.15697. Epub 2021 Sep 29.

BACKGROUND AND AIMS: Molecular genetic studies of alcohol and nicotine use have identified many genome-wide association study (GWAS) loci. We measured associations between drinking and smoking polygenic scores (PGS) and trajectories of alcohol and nicotine use outcomes from late...

The Power of Theory, Research Design, and Transdisciplinary Integration in Moving Psychopathology Forward.

Psychological inquiry

Vaidyanathan U, Vrieze SI, Iacono WG.
PMID: 27030789
Psychol Inq. 2015;26(3):209-230. doi: 10.1080/1047840X.2015.1015367. Epub 2015 Aug 28.

While the past few decades have seen much work in psychopathology research that has yielded provocative insights, relatively little progress has been made in understanding the etiology of mental disorders. We contend that this is due to an overreliance...

Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries.

Genetics

Kwong AM, Blackwell TW, LeFaive J, de Andrade M, Barnard J, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Cade BE, Chasman DI, Chen H, Conomos MP, Cupples LA, Ellinor PT, Eng C, Gao Y, Guo X, Irvin MR, Kelly TN, Kim W, Kooperberg C, Lubitz SA, Mak ACY, Manichaikul AW, Mathias RA, Montasser ME, Montgomery CG, Musani S, Palmer ND, Peloso GM, Qiao D, Reiner AP, Roden DM, Shoemaker MB, Smith JA, Smith NL, Su JL, Tiwari HK, Weeks DE, Weiss ST, Scott LJ, Smith AV, Abecasis GR, Boehnke M, Kang HM.
PMID: 33720349
Genetics. 2021 May 17;218(1). doi: 10.1093/genetics/iyab044.

Traditional Hardy-Weinberg equilibrium (HWE) tests (the χ2 test and the exact test) have long been used as a metric for evaluating genotype quality, as technical artifacts leading to incorrect genotype calls often can be identified as deviations from HWE....

Polygenic Score for Smoking is associated with Externalizing Psychopathology and Disinhibited Personality Traits but not Internalizing Psychopathology in Adolescence.

Clinical psychological science : a journal of the Association for Psychological Science

Hicks BM, Clark DA, Deak JD, Liu M, Durbin CE, Schaefer JD, Wilson S, Iacono WG, McGue M, Vrieze SI.
PMID: 35003907
Clin Psychol Sci. 2021 Nov 01;9(6):1205-1213. doi: 10.1177/21677026211002117. Epub 2021 May 06.

We examined whether a polygenic score (PGS) for smoking measured genetic risk for general behavioral disinhibition by estimating its associations with externalizing and internalizing psychopathology and related personality traits at multiple time points in adolescence (ages 11, 14, and...

Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder.

Psychological medicine

Jang SK, Saunders G, Liu M, Jiang Y, Liu DJ, Vrieze S.
PMID: 32762793
Psychol Med. 2020 Aug 07;1-11. doi: 10.1017/S003329172000272X. Epub 2020 Aug 07.

BACKGROUND: Substance use occurs at a high rate in persons with a psychiatric disorder. Genetically informative studies have the potential to elucidate the etiology of these phenomena. Recent developments in genome-wide association studies (GWAS) allow new avenues of investigation.METHOD:...

Polygenic Score for Smoking is associated with Externalizing Psychopathology and Disinhibited Personality Traits but not Internalizing Psychopathology in Adolescence.

Clinical psychological science : a journal of the Association for Psychological Science

Hicks BM, Clark DA, Deak JD, Liu M, Durbin CE, Schaefer JD, Wilson S, Iacono WG, McGue M, Vrieze SI.
PMID: 35003907
Clin Psychol Sci. 2021 Nov 01;9(6):1205-1213. doi: 10.1177/21677026211002117. Epub 2021 May 06.

We examined whether a polygenic score (PGS) for smoking measured genetic risk for general behavioral disinhibition by estimating its associations with externalizing and internalizing psychopathology and related personality traits at multiple time points in adolescence (ages 11, 14, and...

THE ART OF SMART SCIENCE: WEAVING THEORY AND RISKY STUDY DESIGN INTO PSYCHOPATHOLOGY RESEARCH AND RDOC.

Psychological inquiry

Vaidyanathan U, Vrieze SI, Iacono WG.
PMID: 27019570
Psychol Inq. 2015;26(3):286-292. doi: 10.1080/1047840X.2015.1064066. Epub 2015 Aug 28.

No abstract available.

Showing 1 to 11 of 11 entries