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Understanding the Radiobiology of Vestibular Schwannomas to Overcome Radiation Resistance.

Cancers

Thielhelm TP, Goncalves S, Welford SM, Mellon EA, Cohen ER, Nourbakhsh A, Fernandez-Valle C, Telischi F, Ivan ME, Dinh CT.
PMID: 34572805
Cancers (Basel). 2021 Sep 12;13(18). doi: 10.3390/cancers13184575.

Vestibular schwannomas (VS) are benign tumors arising from cranial nerve VIII that account for 8-10% of all intracranial tumors and are the most common tumors of the cerebellopontine angle. These tumors are typically managed with observation, radiation therapy, or...

Genetics and the Individualized Therapy of Vestibular Disorders.

Frontiers in neurology

Mei C, Dong H, Nisenbaum E, Thielhelm T, Nourbakhsh A, Yan D, Smeal M, Lundberg Y, Hoffer ME, Angeli S, Telischi F, Nie G, Blanton SH, Liu X.
PMID: 33613440
Front Neurol. 2021 Feb 05;12:633207. doi: 10.3389/fneur.2021.633207. eCollection 2021.

No abstract available.

Primary Vestibular Schwannoma Cells Activate p21 and RAD51-Associated DNA Repair Following Radiation-Induced DNA Damage.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Thielhelm TP, Goncalves S, Welford S, Mellon EA, Bracho O, Estivill M, Brown C, Morcos J, Ivan ME, Telischi F, Fernandez-Valle C, Dinh CT.
PMID: 34420024
Otol Neurotol. 2021 Dec 01;42(10):e1600-e1608. doi: 10.1097/MAO.0000000000003322.

HYPOTHESIS: Vestibular Schwannoma (VS) can avoid cell death following radiation injury by entering cell cycle arrest and activating RAD51-related DNA repair.BACKGROUND: Although the radiobiology of various cancers is well-studied, the radiobiological effects in VS are poorly understood. In this...

Showing 1 to 3 of 3 entries