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Showing 1 to 5 of 5 entries
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Sex-Specific Regulation of Interferon-γ Cytotoxicity in Mouse Liver by Autophagy.

Hepatology (Baltimore, Md.)

Shen Y, Cingolani F, Malik SA, Wen J, Liu Y, Czaja MJ.
PMID: 34118081
Hepatology. 2021 Nov;74(5):2745-2758. doi: 10.1002/hep.32010. Epub 2021 Aug 30.

BACKGROUND AND AIMS: Interferon-γ (IFNγ) is a central activator of immune responses in the liver and other organs. IFNγ triggers tissue injury and inflammation in immune diseases, which occur predominantly in females for unknown reasons. Recent findings that autophagy...

Sex-Specific Regulation of Interferon-γ Cytotoxicity in Mouse Liver by Autophagy.

Hepatology (Baltimore, Md.)

Shen Y, Cingolani F, Malik SA, Wen J, Liu Y, Czaja MJ.
PMID: 34118081
Hepatology. 2021 Nov;74(5):2745-2758. doi: 10.1002/hep.32010. Epub 2021 Aug 30.

BACKGROUND AND AIMS: Interferon-γ (IFNγ) is a central activator of immune responses in the liver and other organs. IFNγ triggers tissue injury and inflammation in immune diseases, which occur predominantly in females for unknown reasons. Recent findings that autophagy...

Transcription factor EB: a central regulator of both the autophagosome and lysosome.

Hepatology (Baltimore, Md.)

Zhao E, Czaja MJ.
PMID: 22517549
Hepatology. 2012 May;55(5):1632-4. doi: 10.1002/hep.25619.

No abstract available.

Acetaminophen Intoxication Rapidly Induces Apoptosis of Intestinal Crypt Stem Cells and Enhances Intestinal Permeability.

Hepatology communications

Chopyk DM, Stuart JD, Zimmerman MG, Wen J, Gumber S, Suthar MS, Thapa M, Czaja MJ, Grakoui A.
PMID: 31701068
Hepatol Commun. 2019 Jul 15;3(11):1435-1449. doi: 10.1002/hep4.1406. eCollection 2019 Nov.

Acetaminophen (APAP)-induced liver injury is the most common cause of acute liver failure (ALF) in the Western world. APAP toxicity progresses to multiorgan dysfunction and thus has broader whole-body implications. Importantly, greater 30-day mortality has been observed in liver...

Stathmin 1 Induces Murine Hepatocyte Proliferation and Increased Liver Mass.

Hepatology communications

Zhao E, Shen Y, Amir M, Farris AB, Czaja MJ.
PMID: 31909354
Hepatol Commun. 2019 Nov 07;4(1):38-49. doi: 10.1002/hep4.1447. eCollection 2020 Jan.

The endogenous cellular signals that initiate the transition of hepatocytes from quiescence to proliferation remain unclear. The protein stathmin 1 (STMN1) is highly expressed in dividing cells, including hepatocytes, and functions to promote cell mitosis through physical interactions with...

Showing 1 to 5 of 5 entries