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Showing 1 to 8 of 8 entries
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Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction.

Toxicological research

Chun SK, Go K, Yang MJ, Zendejas I, Behrns KE, Kim JS.
PMID: 26977257
Toxicol Res. 2016 Jan;32(1):35-46. doi: 10.5487/TR.2016.32.1.035. Epub 2016 Jan 31.

No-flow ischemia occurs during cardiac arrest, hemorrhagic shock, liver resection and transplantation. Recovery of blood flow and normal physiological pH, however, irreversibly injures the liver and other tissues. Although the liver has the powerful machinery for mitochondrial quality control,...

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Chun SK, Go K, Yang MJ, et al. Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction. Toxicol Res. 2016;32(1):35-46doi: 10.5487/TR.2016.32.1.035.
Chun, S. K., Go, K., Yang, M. J., Zendejas, I., Behrns, K. E., & Kim, J. S. (2016). Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction. Toxicological research, 32(1), 35-46. https://doi.org/10.5487/TR.2016.32.1.035
Chun, Sung Kook, et al. "Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction." Toxicological research vol. 32,1 (2016): 35-46. doi: https://doi.org/10.5487/TR.2016.32.1.035
Chun SK, Go K, Yang MJ, Zendejas I, Behrns KE, Kim JS. Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction. Toxicol Res. 2016 Jan;32(1):35-46. doi: 10.5487/TR.2016.32.1.035. Epub 2016 Jan 31. PMID: 26977257; PMCID: PMC4780240.
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Mitophagy: therapeutic potentials for liver disease and beyond.

Toxicological research

Lee S, Kim JS.
PMID: 25584143
Toxicol Res. 2014 Dec;30(4):243-50. doi: 10.5487/TR.2014.30.4.243.

Mitochondrial integrity is critical for maintaining proper cellular functions. A key aspect of regulating mitochondrial homeostasis is removing damaged mitochondria through autophagy, a process called mitophagy. Autophagy dysfunction in various disease states can inactivate mitophagy and cause cell death,...

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Lee S, Kim JS. Mitophagy: therapeutic potentials for liver disease and beyond. Toxicol Res. 2014;30(4):243-50doi: 10.5487/TR.2014.30.4.243.
Lee, S., & Kim, J. S. (2014). Mitophagy: therapeutic potentials for liver disease and beyond. Toxicological research, 30(4), 243-50. https://doi.org/10.5487/TR.2014.30.4.243
Lee, Sooyeon, and Kim, Jae-Sung. "Mitophagy: therapeutic potentials for liver disease and beyond." Toxicological research vol. 30,4 (2014): 243-50. doi: https://doi.org/10.5487/TR.2014.30.4.243
Lee S, Kim JS. Mitophagy: therapeutic potentials for liver disease and beyond. Toxicol Res. 2014 Dec;30(4):243-50. doi: 10.5487/TR.2014.30.4.243. PMID: 25584143; PMCID: PMC4289924.
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Role of autophagy in differential sensitivity of hepatocarcinoma cells to sorafenib.

World journal of hepatology

Fischer TD, Wang JH, Vlada A, Kim JS, Behrns KE.
PMID: 25349646
World J Hepatol. 2014 Oct 27;6(10):752-8. doi: 10.4254/wjh.v6.i10.752.

AIM: To investigate the role of sorafenib (SFN) in autophagy of hepatocellular carcinoma (HCC). We evaluated how SFN affects autophagy signaling pathway in human HCC cell lines.METHODS: Two different human HCC cell lines, Hep3B and Huh7, were subjected to...

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Fischer TD, Wang JH, Vlada A, et al. Role of autophagy in differential sensitivity of hepatocarcinoma cells to sorafenib. World J Hepatol. 2014;6(10):752-8doi: 10.4254/wjh.v6.i10.752.
Fischer, T. D., Wang, J. H., Vlada, A., Kim, J. S., & Behrns, K. E. (2014). Role of autophagy in differential sensitivity of hepatocarcinoma cells to sorafenib. World journal of hepatology, 6(10), 752-8. https://doi.org/10.4254/wjh.v6.i10.752
Fischer, Trevan D, et al. "Role of autophagy in differential sensitivity of hepatocarcinoma cells to sorafenib." World journal of hepatology vol. 6,10 (2014): 752-8. doi: https://doi.org/10.4254/wjh.v6.i10.752
Fischer TD, Wang JH, Vlada A, Kim JS, Behrns KE. Role of autophagy in differential sensitivity of hepatocarcinoma cells to sorafenib. World J Hepatol. 2014 Oct 27;6(10):752-8. doi: 10.4254/wjh.v6.i10.752. PMID: 25349646; PMCID: PMC4209420.
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Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts.

Frontiers in cell and developmental biology

Mishra SK, Bae YS, Lee YM, Kim JS, Oh SH, Kim HM.
PMID: 33585438
Front Cell Dev Biol. 2021 Jan 21;8:571676. doi: 10.3389/fcell.2020.571676. eCollection 2020.

Chemosensitization of cancer cells with small molecules may improve the therapeutic index of antitumoral agents by making tumor cells sensitive to the drug regimen and thus overcome the treatment resistance and side effects of single therapy. Cell membrane lipid...

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Mishra SK, Bae YS, Lee YM, et al. Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts. Front Cell Dev Biol. 2021;8:571676doi: 10.3389/fcell.2020.571676.
Mishra, S. K., Bae, Y. S., Lee, Y. M., Kim, J. S., Oh, S. H., & Kim, H. M. (2020). Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts. Frontiers in cell and developmental biology, 8571676. https://doi.org/10.3389/fcell.2020.571676
Mishra, Siddhartha Kumar, et al. "Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts." Frontiers in cell and developmental biology vol. 8 (2020): 571676. doi: https://doi.org/10.3389/fcell.2020.571676
Mishra SK, Bae YS, Lee YM, Kim JS, Oh SH, Kim HM. Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts. Front Cell Dev Biol. 2021 Jan 21;8:571676. doi: 10.3389/fcell.2020.571676. eCollection 2020. PMID: 33585438; PMCID: PMC7874189.
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Cytoprotection of rat hepatocytes by desipramine in a model of simulated ischemia/reperfusion.

Biochemistry and biophysics reports

Shin JK, Kim JS.
PMID: 34337165
Biochem Biophys Rep. 2021 Jul 15;27:101075. doi: 10.1016/j.bbrep.2021.101075. eCollection 2021 Sep.

We investigated the cytoprotective effect of desipramine (DMI) during

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Shin JK, Kim JS. Cytoprotection of rat hepatocytes by desipramine in a model of simulated ischemia/reperfusion. Biochem Biophys Rep. 2021;27:101075doi: 10.1016/j.bbrep.2021.101075.
Shin, J. K., & Kim, J. S. (2021). Cytoprotection of rat hepatocytes by desipramine in a model of simulated ischemia/reperfusion. Biochemistry and biophysics reports, 27101075. https://doi.org/10.1016/j.bbrep.2021.101075
Shin, Jun-Kyu, and Kim, Jae-Sung. "Cytoprotection of rat hepatocytes by desipramine in a model of simulated ischemia/reperfusion." Biochemistry and biophysics reports vol. 27 (2021): 101075. doi: https://doi.org/10.1016/j.bbrep.2021.101075
Shin JK, Kim JS. Cytoprotection of rat hepatocytes by desipramine in a model of simulated ischemia/reperfusion. Biochem Biophys Rep. 2021 Jul 15;27:101075. doi: 10.1016/j.bbrep.2021.101075. eCollection 2021 Sep. PMID: 34337165; PMCID: PMC8313843.
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A Novel Multidrug Combination Mitigates Rat Liver Steatosis Through Activating AMPK Pathway During Normothermic Machine Perfusion.

Transplantation

Xu M, Zhou F, Ahmed O, Upadhya GA, Jia J, Lee C, Xing J, Ye L, Shim SH, Zhang Z, Byrnes K, Wong B, Kim JS, Lin Y, Chapman WC.
PMID: 34019362
Transplantation. 2021 Nov 01;105(11):e215-e225. doi: 10.1097/TP.0000000000003675.

BACKGROUND: Hepatic steatosis is now the leading cause of liver discards in deceased donors. Previous studies [Yarmush formula (Y) defatting] have successfully reduced the fat content by treating rat steatotic livers on extracorporeal normothermic machine perfusion (NMP) with a...

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Xu M, Zhou F, Ahmed O, et al. A Novel Multidrug Combination Mitigates Rat Liver Steatosis Through Activating AMPK Pathway During Normothermic Machine Perfusion. Transplantation. 2021;105(11):e215-e225doi: 10.1097/TP.0000000000003675.
Xu, M., Zhou, F., Ahmed, O., Upadhya, G. A., Jia, J., Lee, C., Xing, J., Ye, L., Shim, S. H., Zhang, Z., Byrnes, K., Wong, B., Kim, J. S., Lin, Y., & Chapman, W. C. (2021). A Novel Multidrug Combination Mitigates Rat Liver Steatosis Through Activating AMPK Pathway During Normothermic Machine Perfusion. Transplantation, 105(11), e215-e225. https://doi.org/10.1097/TP.0000000000003675
Xu, Min, et al. "A Novel Multidrug Combination Mitigates Rat Liver Steatosis Through Activating AMPK Pathway During Normothermic Machine Perfusion." Transplantation vol. 105,11 (2021): e215-e225. doi: https://doi.org/10.1097/TP.0000000000003675
Xu M, Zhou F, Ahmed O, Upadhya GA, Jia J, Lee C, Xing J, Ye L, Shim SH, Zhang Z, Byrnes K, Wong B, Kim JS, Lin Y, Chapman WC. A Novel Multidrug Combination Mitigates Rat Liver Steatosis Through Activating AMPK Pathway During Normothermic Machine Perfusion. Transplantation. 2021 Nov 01;105(11):e215-e225. doi: 10.1097/TP.0000000000003675. PMID: 34019362; PMCID: PMC8356968.
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Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia.

Molecular & cellular oncology

Sooyeon L, Go KL, Kim JS.
PMID: 27308609
Mol Cell Oncol. 2015 Oct 06;3(2):e1087452. doi: 10.1080/23723556.2015.1087452. eCollection 2016 Mar.

Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent...

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Sooyeon L, Go KL, Kim JS. Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia. Mol Cell Oncol. 2015;3(2):e1087452doi: 10.1080/23723556.2015.1087452.
Sooyeon, L., Go, K. L., & Kim, J. S. (2016). Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia. Molecular & cellular oncology, 3(2), e1087452. https://doi.org/10.1080/23723556.2015.1087452
Sooyeon, Lee, et al. "Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia." Molecular & cellular oncology vol. 3,2 (2016): e1087452. doi: https://doi.org/10.1080/23723556.2015.1087452
Sooyeon L, Go KL, Kim JS. Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia. Mol Cell Oncol. 2015 Oct 06;3(2):e1087452. doi: 10.1080/23723556.2015.1087452. eCollection 2016 Mar. PMID: 27308609; PMCID: PMC4905389.
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Dual Lactate Clearance in the Viability Assessment of Livers Donated After Circulatory Death With Ex Situ Normothermic Machine Perfusion.

Transplantation direct

Xu M, Zhou F, Ahmed O, Randle LV, Shin JK, Zhu Y, Upadhya GA, Byrnes K, Wong B, Kim JS, Lin Y, Chapman WC.
PMID: 34805491
Transplant Direct. 2021 Nov 17;7(12):e789. doi: 10.1097/TXD.0000000000001243. eCollection 2021 Dec.

Perfusate lactate clearance (LC) is considered one of the useful indicators of liver viability assessment during normothermic machine perfusion (NMP); however, the applicable scope and potential mechanisms of LC remain poorly defined in the setting of liver donation after...

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Xu M, Zhou F, Ahmed O, et al. Dual Lactate Clearance in the Viability Assessment of Livers Donated After Circulatory Death With Ex Situ Normothermic Machine Perfusion. Transplant Direct. 2021;7(12):e789doi: 10.1097/TXD.0000000000001243.
Xu, M., Zhou, F., Ahmed, O., Randle, L. V., Shin, J. K., Zhu, Y., Upadhya, G. A., Byrnes, K., Wong, B., Kim, J. S., Lin, Y., & Chapman, W. C. (2021). Dual Lactate Clearance in the Viability Assessment of Livers Donated After Circulatory Death With Ex Situ Normothermic Machine Perfusion. Transplantation direct, 7(12), e789. https://doi.org/10.1097/TXD.0000000000001243
Xu, Min, et al. "Dual Lactate Clearance in the Viability Assessment of Livers Donated After Circulatory Death With Ex Situ Normothermic Machine Perfusion." Transplantation direct vol. 7,12 (2021): e789. doi: https://doi.org/10.1097/TXD.0000000000001243
Xu M, Zhou F, Ahmed O, Randle LV, Shin JK, Zhu Y, Upadhya GA, Byrnes K, Wong B, Kim JS, Lin Y, Chapman WC. Dual Lactate Clearance in the Viability Assessment of Livers Donated After Circulatory Death With Ex Situ Normothermic Machine Perfusion. Transplant Direct. 2021 Nov 17;7(12):e789. doi: 10.1097/TXD.0000000000001243. eCollection 2021 Dec. PMID: 34805491; PMCID: PMC8601326.
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Showing 1 to 8 of 8 entries