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Diagnosis of acquired generalized lipodystrophy in a single patient with T-cell lymphoma and no exposure to Metreleptin.

Clinical diabetes and endocrinology

Esfandiari NH, Rubenfire M, Neidert AH, Hench R, Eldin AJ, Meral R, Oral EA.
PMID: 30923630
Clin Diabetes Endocrinol. 2019 Mar 14;5:4. doi: 10.1186/s40842-019-0076-9. eCollection 2019.

BACKGROUND: Metreleptin, a recombinant methionyl -human -leptin, was approved to treat patients with generalized lipodystrophy (GL) in February 2014. However, leptin therapy has been associated with the development of lymphoma. We present a unique case of a patient with...

Efficacy and Safety of Metreleptin in Patients with Partial Lipodystrophy: Lessons from an Expanded Access Program.

Journal of diabetes & metabolism

Ajluni N, Dar M, Xu J, Neidert AH, Oral EA.
PMID: 27642538
J Diabetes Metab. 2016 Mar;7(3). doi: 10.4172/2155-6156.1000659. Epub 2016 Mar 23.

OBJECTIVE: Patients with lipodystrophy have severe metabolic abnormalities (insulin resistance, diabetes, and hypertriglyceridemia) that may increase morbidity and mortality. Metreleptin is approved by the United States Food and Drug Administration for treatment of generalized forms of lipodystrophy. We aimed...

Showing 1 to 2 of 2 entries