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Role of HIPK2 in kidney fibrosis.

Kidney international supplements

Fan Y, Wang N, Chuang P, He JC.
PMID: 26312158
Kidney Int Suppl (2011). 2014 Nov;4(1):97-101. doi: 10.1038/kisup.2014.18.

Homeodomain interacting protein kinase 2 (HIPK2) functions as either a co-repressor or a co-activator of transcriptional regulators. Dysregulation of HIPK2 is associated with cancer and neurological disease. Recently, we found that HIPK2 is also an important driver of kidney...

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Fan Y, Wang N, Chuang P, et al. Role of HIPK2 in kidney fibrosis. Kidney Int Suppl (2011). 2014;4(1):97-101doi: 10.1038/kisup.2014.18.
Fan, Y., Wang, N., Chuang, P., & He, J. C. (2014). Role of HIPK2 in kidney fibrosis. Kidney international supplements, 4(1), 97-101. https://doi.org/10.1038/kisup.2014.18
Fan, Ying, et al. "Role of HIPK2 in kidney fibrosis." Kidney international supplements vol. 4,1 (2014): 97-101. doi: https://doi.org/10.1038/kisup.2014.18
Fan Y, Wang N, Chuang P, He JC. Role of HIPK2 in kidney fibrosis. Kidney Int Suppl (2011). 2014 Nov;4(1):97-101. doi: 10.1038/kisup.2014.18. PMID: 26312158; PMCID: PMC4536960.
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An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions.

Frontiers in cell and developmental biology

Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, Melnick A, Garcia BA, Whetton AD, MacArthur BD, Ma'ayan A, Lemischka IR.
PMID: 33816475
Front Cell Dev Biol. 2021 Mar 19;9:630067. doi: 10.3389/fcell.2021.630067. eCollection 2021.

Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of transcription factors to specific loci, RNA transcription and protein synthesis. However, the mechanisms by which such regulatory "dimensions" coordinate cell fate...

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Sevilla A, Papatsenko D, Mazloom AR, et al. An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Front Cell Dev Biol. 2021;9:630067doi: 10.3389/fcell.2021.630067.
Sevilla, A., Papatsenko, D., Mazloom, A. R., Xu, H., Vasileva, A., Unwin, R. D., LeRoy, G., Chen, E. Y., Garrett-Bakelman, F. E., Lee, D. F., Trinite, B., Webb, R. L., Wang, Z., Su, J., Gingold, J., Melnick, A., Garcia, B. A., Whetton, A. D., MacArthur, B. D., Ma'ayan, A., & Lemischka, I. R. (2021). An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Frontiers in cell and developmental biology, 9630067. https://doi.org/10.3389/fcell.2021.630067
Sevilla, Ana, et al. "An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions." Frontiers in cell and developmental biology vol. 9 (2021): 630067. doi: https://doi.org/10.3389/fcell.2021.630067
Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, Melnick A, Garcia BA, Whetton AD, MacArthur BD, Ma'ayan A, Lemischka IR. An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Front Cell Dev Biol. 2021 Mar 19;9:630067. doi: 10.3389/fcell.2021.630067. eCollection 2021. PMID: 33816475; PMCID: PMC8017264.
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Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy.

Oncotarget

He L, Fan Y, Xiao W, Chen T, Wen J, Dong Y, Wang Y, Li S, Xue R, Zheng L, He JC, Wang N.
PMID: 29340054
Oncotarget. 2017 Nov 30;8(67):111295-111308. doi: 10.18632/oncotarget.22784. eCollection 2017 Dec 19.

Hyperuricemia contributes to kidney tubular injury and kidney fibrosis. However, the underlying mechanism remains unclear. Here we examined the role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein and ER stress in hyperuricemic nephropathy. We first found the expression...

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He L, Fan Y, Xiao W, et al. Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy. Oncotarget. 2017;8(67):111295-111308doi: 10.18632/oncotarget.22784.
He, L., Fan, Y., Xiao, W., Chen, T., Wen, J., Dong, Y., Wang, Y., Li, S., Xue, R., Zheng, L., He, J. C., & Wang, N. (2017). Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy. Oncotarget, 8(67), 111295-111308. https://doi.org/10.18632/oncotarget.22784
He, Li, et al. "Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy." Oncotarget vol. 8,67 (2017): 111295-111308. doi: https://doi.org/10.18632/oncotarget.22784
He L, Fan Y, Xiao W, Chen T, Wen J, Dong Y, Wang Y, Li S, Xue R, Zheng L, He JC, Wang N. Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy. Oncotarget. 2017 Nov 30;8(67):111295-111308. doi: 10.18632/oncotarget.22784. eCollection 2017 Dec 19. PMID: 29340054; PMCID: PMC5762322.
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Metasignatures identify two major subtypes of breast cancer.

CPT: pharmacometrics & systems pharmacology

Duan Q, Kou Y, Clark NR, Gordonov S, Ma'ayan A.
PMID: 23836026
CPT Pharmacometrics Syst Pharmacol. 2013 Mar 27;2:e35. doi: 10.1038/psp.2013.11.

Genome-wide expression data from tumors and cell lines in breast cancer, together with drug response of cell lines, open prospects for integrative analyses that can lead to better personalized therapy. Drug responses and expression data collected from cell lines...

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Duan Q, Kou Y, Clark NR, et al. Metasignatures identify two major subtypes of breast cancer. CPT Pharmacometrics Syst Pharmacol. 2013;2:e35doi: 10.1038/psp.2013.11.
Duan, Q., Kou, Y., Clark, N. R., Gordonov, S., & Ma'ayan, A. (2013). Metasignatures identify two major subtypes of breast cancer. CPT: pharmacometrics & systems pharmacology, 2e35. https://doi.org/10.1038/psp.2013.11
Duan, Q, et al. "Metasignatures identify two major subtypes of breast cancer." CPT: pharmacometrics & systems pharmacology vol. 2 (2013): e35. doi: https://doi.org/10.1038/psp.2013.11
Duan Q, Kou Y, Clark NR, Gordonov S, Ma'ayan A. Metasignatures identify two major subtypes of breast cancer. CPT Pharmacometrics Syst Pharmacol. 2013 Mar 27;2:e35. doi: 10.1038/psp.2013.11. PMID: 23836026; PMCID: PMC3615534.
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HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease.

Frontiers in physiology

Nugent MM, Lee K, He JC.
PMID: 25972814
Front Physiol. 2015 Apr 28;6:132. doi: 10.3389/fphys.2015.00132. eCollection 2015.

In vitro and animal studies continue to elucidate the mechanisms of fibrosis and have led to advancements in treatment for idiopathic pulmonary fibrosis and cirrhosis, but the search for treatments for renal fibrosis has been more disappointing. Here, we...

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Nugent MM, Lee K, He JC. HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease. Front Physiol. 2015;6:132doi: 10.3389/fphys.2015.00132.
Nugent, M. M., Lee, K., & He, J. C. (2015). HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease. Frontiers in physiology, 6132. https://doi.org/10.3389/fphys.2015.00132
Nugent, Melinda M, et al. "HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease." Frontiers in physiology vol. 6 (2015): 132. doi: https://doi.org/10.3389/fphys.2015.00132
Nugent MM, Lee K, He JC. HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease. Front Physiol. 2015 Apr 28;6:132. doi: 10.3389/fphys.2015.00132. eCollection 2015. PMID: 25972814; PMCID: PMC4411988.
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The beneficial role of retinoids in glomerular disease.

Frontiers in medicine

Mallipattu SK, He JC.
PMID: 25853135
Front Med (Lausanne). 2015 Mar 23;2:16. doi: 10.3389/fmed.2015.00016. eCollection 2015.

The primary etiology of CKD is a direct consequence of initial dysfunction and injury of the glomerulus, the main filtration system. Podocytes are terminally differentiated epithelial cells in the glomerulus, whose major function is the maintenance of this renal...

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Mallipattu SK, He JC. The beneficial role of retinoids in glomerular disease. Front Med (Lausanne). 2015;2:16doi: 10.3389/fmed.2015.00016.
Mallipattu, S. K., & He, J. C. (2015). The beneficial role of retinoids in glomerular disease. Frontiers in medicine, 216. https://doi.org/10.3389/fmed.2015.00016
Mallipattu, Sandeep K, and He, John Cijiang. "The beneficial role of retinoids in glomerular disease." Frontiers in medicine vol. 2 (2015): 16. doi: https://doi.org/10.3389/fmed.2015.00016
Mallipattu SK, He JC. The beneficial role of retinoids in glomerular disease. Front Med (Lausanne). 2015 Mar 23;2:16. doi: 10.3389/fmed.2015.00016. eCollection 2015. PMID: 25853135; PMCID: PMC4370041.
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Introduction to statistical methods to analyze large data sets: principal components analysis.

Science signaling

Clark NR, Ma'ayan A.
PMID: 21917717
Sci Signal. 2011 Sep 06;4(190):tr3. doi: 10.1126/scisignal.2001967.

This Teaching Resource provides lecture notes, slides, and a problem set for a series of lectures from a course entitled "Systems Biology: Biomedical Modeling." The materials are a lecture introducing the mathematical concepts behind principal components analysis (PCA). The...

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Clark NR, Ma'ayan A. Introduction to statistical methods to analyze large data sets: principal components analysis. Sci Signal. 2011;4(190):tr3doi: 10.1126/scisignal.2001967.
Clark, N. R., & Ma'ayan, A. (2011). Introduction to statistical methods to analyze large data sets: principal components analysis. Science signaling, 4(190), tr3. https://doi.org/10.1126/scisignal.2001967
Clark, Neil R, and Ma'ayan, Avi. "Introduction to statistical methods to analyze large data sets: principal components analysis." Science signaling vol. 4,190 (2011): tr3. doi: https://doi.org/10.1126/scisignal.2001967
Clark NR, Ma'ayan A. Introduction to statistical methods to analyze large data sets: principal components analysis. Sci Signal. 2011 Sep 06;4(190):tr3. doi: 10.1126/scisignal.2001967. PMID: 21917717; PMCID: PMC3193798.
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SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease.

Frontiers in endocrinology

Zhong Y, Lee K, He JC.
PMID: 30386303
Front Endocrinol (Lausanne). 2018 Oct 17;9:624. doi: 10.3389/fendo.2018.00624. eCollection 2018.

Multiple studies have demonstrated a critical role of Sirtuin-1 (SIRT1) deacetylase in protecting kidney cells from cellular stresses. A protective role of SIRT1 has been reported in both podocytes and renal tubular cells in multiple kidney disease settings, including...

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Zhong Y, Lee K, He JC. SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2018;9:624doi: 10.3389/fendo.2018.00624.
Zhong, Y., Lee, K., & He, J. C. (2018). SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease. Frontiers in endocrinology, 9624. https://doi.org/10.3389/fendo.2018.00624
Zhong, Yifei, et al. "SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease." Frontiers in endocrinology vol. 9 (2018): 624. doi: https://doi.org/10.3389/fendo.2018.00624
Zhong Y, Lee K, He JC. SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2018 Oct 17;9:624. doi: 10.3389/fendo.2018.00624. eCollection 2018. PMID: 30386303; PMCID: PMC6199382.
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Showing 1 to 8 of 8 entries