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Showing 1 to 12 of 41 entries
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Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Journal of clinical and translational research

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H.
PMID: 26722668
J Clin Transl Res. 2015;1(2):100-106. doi: 10.18053/jctres.201502.004. Epub 2015 Sep 30.

BACKGROUND: Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mechanistic studies in mice and humans have implicated formation of a reactive metabolite, mitochondrial dysfunction and oxidant stress as critical events in the pathophysiology...

Cite
Xie Y, Woolbright BL, Kos M, et al. Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. J Clin Transl Res. 2015;1(2):100-106doi: 10.18053/jctres.201502.004.
Xie, Y., Woolbright, B. L., Kos, M., McGill, M. R., Dorko, K., Kumer, S. C., Schmitt, T. M., & Jaeschke, H. (2015). Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. Journal of clinical and translational research, 1(2), 100-106. https://doi.org/10.18053/jctres.201502.004
Xie, Yuchao, et al. "Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity." Journal of clinical and translational research vol. 1,2 (2015): 100-106. doi: https://doi.org/10.18053/jctres.201502.004
Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H. Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. J Clin Transl Res. 2015;1(2):100-106. doi: 10.18053/jctres.201502.004. Epub 2015 Sep 30. PMID: 26722668; PMCID: PMC4694640.
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Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.

Journal of clinical and translational research

Ramachandran A, Jaeschke H.
PMID: 28670625
J Clin Transl Res. 2017 Feb;3:157-169. doi: 10.18053/jctres.03.2017S1.002. Epub 2017 Feb 12.

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and mechanisms of liver injury induced by APAP overdose have been the focus of extensive investigation. Studies in the mouse model, which closely...

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Ramachandran A, Jaeschke H. Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology. J Clin Transl Res. 2017;3:157-169doi: 10.18053/jctres.03.2017S1.002.
Ramachandran, A., & Jaeschke, H. (2017). Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology. Journal of clinical and translational research, 3157-169. https://doi.org/10.18053/jctres.03.2017S1.002
Ramachandran, Anup, and Jaeschke, Hartmut. "Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology." Journal of clinical and translational research vol. 3 (2017): 157-169. doi: https://doi.org/10.18053/jctres.03.2017S1.002
Ramachandran A, Jaeschke H. Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology. J Clin Transl Res. 2017 Feb;3:157-169. doi: 10.18053/jctres.03.2017S1.002. Epub 2017 Feb 12. PMID: 28670625; PMCID: PMC5489132.
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Adipose tissue autophagy and homeostasis in alcohol-induced liver injury.

Liver research

Li Y, Ding WX.
PMID: 29109891
Liver Res. 2017 Jun;1(1):54-62. doi: 10.1016/j.livres.2017.03.004. Epub 2017 Apr 26.

Alcohol consumption leads to injury in multiple organs and systems, including the liver, brain, heart, skeletal muscle, pancreas, bone, immune system, and endocrine system. Emerging evidence indicates that alcohol also promotes adipose tissue dysfunction, which may contribute to injury...

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Li Y, Ding WX. Adipose tissue autophagy and homeostasis in alcohol-induced liver injury. Liver Res. 2017;1(1):54-62doi: 10.1016/j.livres.2017.03.004.
Li, Y., & Ding, W. X. (2017). Adipose tissue autophagy and homeostasis in alcohol-induced liver injury. Liver research, 1(1), 54-62. https://doi.org/10.1016/j.livres.2017.03.004
Li, Yuan, and Ding, Wen-Xing. "Adipose tissue autophagy and homeostasis in alcohol-induced liver injury." Liver research vol. 1,1 (2017): 54-62. doi: https://doi.org/10.1016/j.livres.2017.03.004
Li Y, Ding WX. Adipose tissue autophagy and homeostasis in alcohol-induced liver injury. Liver Res. 2017 Jun;1(1):54-62. doi: 10.1016/j.livres.2017.03.004. Epub 2017 Apr 26. PMID: 29109891; PMCID: PMC5669268.
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A fluorescence imaging based-assay to monitor mitophagy in cultured hepatocytes and mouse liver.

Liver research

Ma X, Ding WX.
PMID: 34350054
Liver Res. 2021 Mar;5(1):16-20. doi: 10.1016/j.livres.2020.12.002. Epub 2021 Jan 28.

BACKGROUND AND AIM: Mitophagy is a lysosomal degradation pathway that selectively removes damaged, aged and dysfunctional mitochondria. Recent advances in understanding mitophagy highlight its importance in various physiological and pathological conditions including liver diseases. However, reliable quantitative assays to...

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Ma X, Ding WX. A fluorescence imaging based-assay to monitor mitophagy in cultured hepatocytes and mouse liver. Liver Res. 2021;5(1):16-20doi: 10.1016/j.livres.2020.12.002.
Ma, X., & Ding, W. X. (2021). A fluorescence imaging based-assay to monitor mitophagy in cultured hepatocytes and mouse liver. Liver research, 5(1), 16-20. https://doi.org/10.1016/j.livres.2020.12.002
Ma, Xiaowen, and Ding, Wen-Xing. "A fluorescence imaging based-assay to monitor mitophagy in cultured hepatocytes and mouse liver." Liver research vol. 5,1 (2021): 16-20. doi: https://doi.org/10.1016/j.livres.2020.12.002
Ma X, Ding WX. A fluorescence imaging based-assay to monitor mitophagy in cultured hepatocytes and mouse liver. Liver Res. 2021 Mar;5(1):16-20. doi: 10.1016/j.livres.2020.12.002. Epub 2021 Jan 28. PMID: 34350054; PMCID: PMC8330398.
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Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.

Archives of toxicology

Akakpo JY, Ramachandran A, Curry SC, Rumack BH, Jaeschke H.
PMID: 34978586
Arch Toxicol. 2022 Jan 03; doi: 10.1007/s00204-021-03211-z. Epub 2022 Jan 03.

Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 years after its introduction. The standard oral or intravenous dosing regimen of NAC is highly effective for...

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Akakpo JY, Ramachandran A, Curry SC, et al. Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Arch Toxicol. 2022;doi: 10.1007/s00204-021-03211-z.
Akakpo, J. Y., Ramachandran, A., Curry, S. C., Rumack, B. H., & Jaeschke, H. (2022). Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of toxicology, . https://doi.org/10.1007/s00204-021-03211-z
Akakpo, Jephte Y, et al. "Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose." Archives of toxicology vol. (2022). doi: https://doi.org/10.1007/s00204-021-03211-z
Akakpo JY, Ramachandran A, Curry SC, Rumack BH, Jaeschke H. Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Arch Toxicol. 2022 Jan 03; doi: 10.1007/s00204-021-03211-z. Epub 2022 Jan 03. PMID: 34978586.
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Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.

Archives of toxicology

Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, Ramachandran A, Jaeschke H.
PMID: 34724096
Arch Toxicol. 2022 Jan;96(1):305-320. doi: 10.1007/s00204-021-03183-0. Epub 2021 Nov 01.

Acetaminophen (APAP) is a widely used analgesic, but also a main cause of acute liver injury in the United States and many western countries. APAP hepatotoxicity is associated with a sterile inflammatory response as shown by the infiltration of...

Cite
Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, et al. Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Arch Toxicol. 2021;96(1):305-320doi: 10.1007/s00204-021-03183-0.
Nguyen, N. T., Umbaugh, D. S., Sanchez-Guerrero, G., Ramachandran, A., & Jaeschke, H. (2022). Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Archives of toxicology, 96(1), 305-320. https://doi.org/10.1007/s00204-021-03183-0
Nguyen, Nga T, et al. "Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice." Archives of toxicology vol. 96,1 (2022): 305-320. doi: https://doi.org/10.1007/s00204-021-03183-0
Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, Ramachandran A, Jaeschke H. Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Arch Toxicol. 2022 Jan;96(1):305-320. doi: 10.1007/s00204-021-03183-0. Epub 2021 Nov 01. PMID: 34724096.
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Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products.

Toxicology letters

Jaeschke H, Ramachandran A.
PMID: 34801638
Toxicol Lett. 2022 Feb 01;355:170-171. doi: 10.1016/j.toxlet.2021.11.006. Epub 2021 Nov 18.

No abstract available.

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Jaeschke H, Ramachandran A. Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products. Toxicol Lett. 2021;355:170-171doi: 10.1016/j.toxlet.2021.11.006.
Jaeschke, H., & Ramachandran, A. (2022). Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products. Toxicology letters, 355170-171. https://doi.org/10.1016/j.toxlet.2021.11.006
Jaeschke, Hartmut, and Ramachandran, Anup. "Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products." Toxicology letters vol. 355 (2022): 170-171. doi: https://doi.org/10.1016/j.toxlet.2021.11.006
Jaeschke H, Ramachandran A. Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products. Toxicol Lett. 2022 Feb 01;355:170-171. doi: 10.1016/j.toxlet.2021.11.006. Epub 2021 Nov 18. PMID: 34801638.
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Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice.

Liver research

Sun H, Ni HM, McCracken JM, Akakpo JY, Fulte S, McKeen T, Jaeschke H, Wang H, Ding WX.
PMID: 34504721
Liver Res. 2021 Jun;5(2):79-87. doi: 10.1016/j.livres.2021.03.001. Epub 2021 Mar 19.

BACKGROUND: Acetaminophen (APAP) overdose can cause liver injury and liver failure, which is one of the most common causes of drug-induced liver injury in the United States. Pharmacological activation of autophagy by inhibiting mechanistic target of rapamycin (mTOR) protects...

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Sun H, Ni HM, McCracken JM, et al. Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice. Liver Res. 2021;5(2):79-87doi: 10.1016/j.livres.2021.03.001.
Sun, H., Ni, H. M., McCracken, J. M., Akakpo, J. Y., Fulte, S., McKeen, T., Jaeschke, H., Wang, H., & Ding, W. X. (2021). Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice. Liver research, 5(2), 79-87. https://doi.org/10.1016/j.livres.2021.03.001
Sun, Hua, et al. "Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice." Liver research vol. 5,2 (2021): 79-87. doi: https://doi.org/10.1016/j.livres.2021.03.001
Sun H, Ni HM, McCracken JM, Akakpo JY, Fulte S, McKeen T, Jaeschke H, Wang H, Ding WX. Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice. Liver Res. 2021 Jun;5(2):79-87. doi: 10.1016/j.livres.2021.03.001. Epub 2021 Mar 19. PMID: 34504721; PMCID: PMC8425470.
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Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.

Archives of toxicology

Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, Ramachandran A, Jaeschke H.
PMID: 34724096
Arch Toxicol. 2022 Jan;96(1):305-320. doi: 10.1007/s00204-021-03183-0. Epub 2021 Nov 01.

Acetaminophen (APAP) is a widely used analgesic, but also a main cause of acute liver injury in the United States and many western countries. APAP hepatotoxicity is associated with a sterile inflammatory response as shown by the infiltration of...

Cite
Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, et al. Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Arch Toxicol. 2021;96(1):305-320doi: 10.1007/s00204-021-03183-0.
Nguyen, N. T., Umbaugh, D. S., Sanchez-Guerrero, G., Ramachandran, A., & Jaeschke, H. (2022). Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Archives of toxicology, 96(1), 305-320. https://doi.org/10.1007/s00204-021-03183-0
Nguyen, Nga T, et al. "Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice." Archives of toxicology vol. 96,1 (2022): 305-320. doi: https://doi.org/10.1007/s00204-021-03183-0
Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, Ramachandran A, Jaeschke H. Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Arch Toxicol. 2022 Jan;96(1):305-320. doi: 10.1007/s00204-021-03183-0. Epub 2021 Nov 01. PMID: 34724096; PMCID: PMC8762790.
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THE ROLE OF OXIDANT STRESS IN ACETAMINOPHE-INDUCED LIVER INJURY.

Current opinion in toxicology

Jaeschke H, Ramachandran A.
PMID: 32309680
Curr Opin Toxicol. 2020 Apr-Jun;20:9-14. doi: 10.1016/j.cotox.2020.03.003. Epub 2020 Mar 25.

Acetaminophen is a widely used analgesic and antipyretic, which can cause liver injury after an overdose. Although a controversial topic for some time, solid evidence for a critical role of oxidative and nitrosative stress has emerged during the last...

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Jaeschke H, Ramachandran A. THE ROLE OF OXIDANT STRESS IN ACETAMINOPHE-INDUCED LIVER INJURY. Curr Opin Toxicol. 2020;20:9-14doi: 10.1016/j.cotox.2020.03.003.
Jaeschke, H., & Ramachandran, A. (2020). THE ROLE OF OXIDANT STRESS IN ACETAMINOPHE-INDUCED LIVER INJURY. Current opinion in toxicology, 209-14. https://doi.org/10.1016/j.cotox.2020.03.003
Jaeschke, Hartmut, and Ramachandran, Anup. "THE ROLE OF OXIDANT STRESS IN ACETAMINOPHE-INDUCED LIVER INJURY." Current opinion in toxicology vol. 20 (2020): 9-14. doi: https://doi.org/10.1016/j.cotox.2020.03.003
Jaeschke H, Ramachandran A. THE ROLE OF OXIDANT STRESS IN ACETAMINOPHE-INDUCED LIVER INJURY. Curr Opin Toxicol. 2020 Apr-Jun;20:9-14. doi: 10.1016/j.cotox.2020.03.003. Epub 2020 Mar 25. PMID: 32309680; PMCID: PMC7164773.
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Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products.

Toxicology letters

Jaeschke H, Ramachandran A.
PMID: 34801638
Toxicol Lett. 2022 Feb 01;355:170-171. doi: 10.1016/j.toxlet.2021.11.006. Epub 2021 Nov 18.

No abstract available.

Cite
Jaeschke H, Ramachandran A. Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products. Toxicol Lett. 2021;355:170-171doi: 10.1016/j.toxlet.2021.11.006.
Jaeschke, H., & Ramachandran, A. (2022). Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products. Toxicology letters, 355170-171. https://doi.org/10.1016/j.toxlet.2021.11.006
Jaeschke, Hartmut, and Ramachandran, Anup. "Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products." Toxicology letters vol. 355 (2022): 170-171. doi: https://doi.org/10.1016/j.toxlet.2021.11.006
Jaeschke H, Ramachandran A. Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products. Toxicol Lett. 2022 Feb 01;355:170-171. doi: 10.1016/j.toxlet.2021.11.006. Epub 2021 Nov 18. PMID: 34801638.
Copy Download .nbib Format: NLM
Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.

Archives of toxicology

Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, Ramachandran A, Jaeschke H.
PMID: 34724096
Arch Toxicol. 2021 Nov 01; doi: 10.1007/s00204-021-03183-0. Epub 2021 Nov 01.

Acetaminophen (APAP) is a widely used analgesic, but also a main cause of acute liver injury in the United States and many western countries. APAP hepatotoxicity is associated with a sterile inflammatory response as shown by the infiltration of...

Cite
Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, et al. Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Arch Toxicol. 2021;doi: 10.1007/s00204-021-03183-0.
Nguyen, N. T., Umbaugh, D. S., Sanchez-Guerrero, G., Ramachandran, A., & Jaeschke, H. (2021). Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Archives of toxicology, . https://doi.org/10.1007/s00204-021-03183-0
Nguyen, Nga T, et al. "Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice." Archives of toxicology vol. (2021). doi: https://doi.org/10.1007/s00204-021-03183-0
Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, Ramachandran A, Jaeschke H. Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Arch Toxicol. 2021 Nov 01; doi: 10.1007/s00204-021-03183-0. Epub 2021 Nov 01. PMID: 34724096.
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Showing 1 to 12 of 41 entries