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Showing 1 to 12 of 14 entries
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Gastrointestinal symptoms, pathophysiology, and treatment in COVID-19.

Genes & diseases

Zhang J, Garrett S, Sun J.
PMID: 33521210
Genes Dis. 2021 Jul;8(4):385-400. doi: 10.1016/j.gendis.2020.08.013. Epub 2020 Sep 05.

The novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has emerged and is responsible for the Coronavirus Disease 2019 global pandemic. Coronaviruses, including SARS-CoV-2, are strongly associated with respiratory symptoms during infection, but gastrointestinal symptoms, such as diarrhea,...

Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis.

Gut microbes

Zhang Y, Ogbu D, Garrett S, Xia Y, Sun J.
PMID: 34812107
Gut Microbes. 2021 Jan-Dec;13(1):1996848. doi: 10.1080/19490976.2021.1996848.

Amyotrophic Lateral Sclerosis is a neuromuscular disease characterized by the progressive death of motor neurons and muscle atrophy. The gastrointestinal symptoms in ALS patients were largely ignored or underestimated. The relationship between the enteric neuromuscular system and microbiome in...

Intestinal organoid as an .

Frontiers in biology

Sun J.
PMID: 30867660
Front Biol (Beijing). 2017 Apr;12(2):94-102. doi: 10.1007/s11515-017-1444-4. Epub 2017 Mar 07.

BACKGROUND: Organoid is an OBJECTIVE: In the present work, we will review the brief history and recent findings using organoids for studying host-microbial interactions.METHODS: A systematic literature search was performed using the PubMed search engine. We also shared our...

Inflammation and intestinal leakiness in older HIV+ individuals with fish oil treatment.

Genes & diseases

Zhang YG, Xia Y, Lu R, Sun J.
PMID: 30320186
Genes Dis. 2018 Jul 11;5(3):220-225. doi: 10.1016/j.gendis.2018.07.001. eCollection 2018 Sep.

Fish oil is a natural product that has shown efficacy for managing inflammatory conditions with few side effects. There is emerging evidence that crosstalks between gut epithelial cells and immune cells contribute to chronic infectious diseases. HIV-infected (HIV+) older...

Presence of .

Oncotarget

Lu R, Bosland M, Xia Y, Zhang YG, Kato I, Sun J.
PMID: 28903406
Oncotarget. 2017 Jul 06;8(33):55104-55115. doi: 10.18632/oncotarget.19052. eCollection 2017 Aug 15.

Evidence directly supporting an association between

Overexpression of Vitamin D Receptor in Intestinal Epithelia Protects Against Colitis via Upregulating Tight Junction Protein Claudin 15.

Journal of Crohn's & colitis

Chatterjee I, Zhang Y, Zhang J, Lu R, Xia Y, Sun J.
PMID: 33690841
J Crohns Colitis. 2021 Oct 07;15(10):1720-1736. doi: 10.1093/ecco-jcc/jjab044.

BACKGROUND AND AIMS: Dysfunction of the vitamin D receptor [VDR] contributes to the aetiology of IBD by regulating autophagy, immune response, and mucosal permeability. VDR directly controls the paracellular tight junction protein Claudin-2. Claudin-2 and Claudin-15 are unique in...

Imbalance of the intestinal virome and altered viral-bacterial interactions caused by a conditional deletion of the vitamin D receptor.

Gut microbes

Zhang J, Zhang Y, Xia Y, Sun J.
PMID: 34375154
Gut Microbes. 2021 Jan-Dec;13(1):1957408. doi: 10.1080/19490976.2021.1957408.

Vitamin D receptor (VDR) deficiency is associated with cancer, infection, and chronic inflammation. Prior research has demonstrated VDR regulation of bacteria; however, little is known regarding VDR and viruses. We hypothesize that VDR deficiency impacts on the intestinal virome...

Gut microbiota, inflammation and colorectal cancer.

Genes & diseases

Sun J, Kato I.
PMID: 28078319
Genes Dis. 2016 Jun;3(2):130-143. doi: 10.1016/j.gendis.2016.03.004. Epub 2016 Apr 13.

Although genes contribute to colorectal cancer, the gut microbiota are an important player. Accumulating evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression. A variety of bacterial species and tumor-promoting virulence mechanisms...

Dirty environment for adult life: The bad, the good, the unknown.

Genes & diseases

Sun J.
PMID: 30258886
Genes Dis. 2016 Jul 09;3(3):167-168. doi: 10.1016/j.gendis.2016.07.001. eCollection 2016 Sep.

We know the bad things of dirty environment which is associated with infectious diseases. In this Research Watch, we discuss the good and the unknown of dirty environment, based on a recent

Diseases (Basel, Switzerland)

Zha L, Garrett S, Sun J.
PMID: 30857369
Diseases. 2019 Mar 10;7(1). doi: 10.3390/diseases7010028.

No abstract available.

Regulation of Microbiota by Vitamin D Receptor: A Nuclear Weapon in Metabolic Diseases.

Nuclear receptor research

Bakke D, Chatterjee I, Agrawal A, Dai Y, Sun J.
PMID: 30828578
Nucl Receptor Res. 2018;5. doi: 10.11131/2018/101377. Epub 2018 Aug 09.

Metabolic syndrome is a multi-faceted disease. The microbiota, as a newly discovered organ, contributes to the pathogenesis and progression of metabolic syndrome. Recent studies have demonstrated that nuclear receptors play critical roles in metabolic diseases. In the current review,...

Commentary: Target Intestinal Microbiota to Alleviate Disease Progression in Amyotrophic Lateral Sclerosis.

Journal of neurology & neuromedicine

Sun J.
PMID: 29152613
J Neurol Neuromedicine. 2017;2(6):13-15. doi: 10.29245/2572.942x/2017/6.1136. Epub 2017 Jun 12.

No abstract available.

Showing 1 to 12 of 14 entries