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Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar.

Journal of the American College of Cardiology

Kim DS, Gloyn AL, Knowles JW.
PMID: 34325839
J Am Coll Cardiol. 2021 Aug 03;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346.

Type 2 diabetes (T2D) is highly prevalent and is a strong contributor for cardiovascular disease. However, there is significant heterogeneity in disease pathogenesis and the risk of complications. Enormous progress has been made in our ability to catalog genetic...

Cite
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021;78(5):496-512doi: 10.1016/j.jacc.2021.03.346.
Kim, D. S., Gloyn, A. L., & Knowles, J. W. (2021). Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. Journal of the American College of Cardiology, 78(5), 496-512. https://doi.org/10.1016/j.jacc.2021.03.346
Kim, Daniel Seung, et al. "Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar." Journal of the American College of Cardiology vol. 78,5 (2021): 496-512. doi: https://doi.org/10.1016/j.jacc.2021.03.346
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021 Aug 03;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346. PMID: 34325839; PMCID: PMC8328195.
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Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank.

Diabetologia

Fall T, Gustafsson S, Orho-Melander M, Ingelsson E.
PMID: 30003307
Diabetologia. 2018 Oct;61(10):2174-2179. doi: 10.1007/s00125-018-4686-z. Epub 2018 Jul 12.

AIMS/HYPOTHESIS: Coronary artery disease (CAD) is a common complication among individuals with diabetes. A better understanding of the genetic background of CAD in this population has the potential to suggest novel molecular targets for screening, risk assessment and drug...

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Fall T, Gustafsson S, Orho-Melander M, et al. Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank. Diabetologia. 2018;61(10):2174-2179doi: 10.1007/s00125-018-4686-z.
Fall, T., Gustafsson, S., Orho-Melander, M., & Ingelsson, E. (2018). Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank. Diabetologia, 61(10), 2174-2179. https://doi.org/10.1007/s00125-018-4686-z
Fall, Tove, et al. "Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank." Diabetologia vol. 61,10 (2018): 2174-2179. doi: https://doi.org/10.1007/s00125-018-4686-z
Fall T, Gustafsson S, Orho-Melander M, Ingelsson E. Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank. Diabetologia. 2018 Oct;61(10):2174-2179. doi: 10.1007/s00125-018-4686-z. Epub 2018 Jul 12. PMID: 30003307; PMCID: PMC6133153.
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Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar.

Journal of the American College of Cardiology

Kim DS, Gloyn AL, Knowles JW.
PMID: 34325839
J Am Coll Cardiol. 2021 Aug 03;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346.

Type 2 diabetes (T2D) is highly prevalent and is a strong contributor for cardiovascular disease. However, there is significant heterogeneity in disease pathogenesis and the risk of complications. Enormous progress has been made in our ability to catalog genetic...

Cite
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021;78(5):496-512doi: 10.1016/j.jacc.2021.03.346.
Kim, D. S., Gloyn, A. L., & Knowles, J. W. (2021). Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. Journal of the American College of Cardiology, 78(5), 496-512. https://doi.org/10.1016/j.jacc.2021.03.346
Kim, Daniel Seung, et al. "Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar." Journal of the American College of Cardiology vol. 78,5 (2021): 496-512. doi: https://doi.org/10.1016/j.jacc.2021.03.346
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021 Aug 03;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346. PMID: 34325839; PMCID: PMC8328195.
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Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex.

The Journal of clinical investigation

Haider N, Lebastchi J, Jayavelu AK, Batista TM, Pan H, Dreyfuss JM, Carcamo-Orive I, Knowles JW, Mann M, Kahn CR.
PMID: 34506305
J Clin Invest. 2021 Nov 01;131(21). doi: 10.1172/JCI151818.

Insulin resistance is present in one-quarter of the general population, predisposing these people to a wide range of diseases. Our aim was to identify cell-intrinsic determinants of insulin resistance in this population using induced pluripotent stem cell-derived (iPSC-derived) myoblasts...

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Haider N, Lebastchi J, Jayavelu AK, et al. Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex. J Clin Invest. 2021;131(21)doi: 10.1172/JCI151818.
Haider, N., Lebastchi, J., Jayavelu, A. K., Batista, T. M., Pan, H., Dreyfuss, J. M., Carcamo-Orive, I., Knowles, J. W., Mann, M., & Kahn, C. R. (2021). Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex. The Journal of clinical investigation, 131(21), . https://doi.org/10.1172/JCI151818
Haider, Nida, et al. "Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex." The Journal of clinical investigation vol. 131,21 (2021). doi: https://doi.org/10.1172/JCI151818
Haider N, Lebastchi J, Jayavelu AK, Batista TM, Pan H, Dreyfuss JM, Carcamo-Orive I, Knowles JW, Mann M, Kahn CR. Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex. J Clin Invest. 2021 Nov 01;131(21). doi: 10.1172/JCI151818. PMID: 34506305; PMCID: PMC8553553.
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The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case.

Current opinion in lipidology

Wand H, Knowles JW, Clarke SL.
PMID: 33538426
Curr Opin Lipidol. 2021 Apr 01;32(2):89-95. doi: 10.1097/MOL.0000000000000733.

PURPOSE OF REVIEW: Polygenic scores (PGS) are used to quantify the genetic predisposition for heritable traits, with hypothesized utility for personalized risk assessments. Lipid PGS are primed for clinical translation, but evidence-based practice changes will require rigorous PGS standards...

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Wand H, Knowles JW, Clarke SL. The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case. Curr Opin Lipidol. 2021;32(2):89-95doi: 10.1097/MOL.0000000000000733.
Wand, H., Knowles, J. W., & Clarke, S. L. (2021). The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case. Current opinion in lipidology, 32(2), 89-95. https://doi.org/10.1097/MOL.0000000000000733
Wand, Hannah, et al. "The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case." Current opinion in lipidology vol. 32,2 (2021): 89-95. doi: https://doi.org/10.1097/MOL.0000000000000733
Wand H, Knowles JW, Clarke SL. The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case. Curr Opin Lipidol. 2021 Apr 01;32(2):89-95. doi: 10.1097/MOL.0000000000000733. PMID: 33538426; PMCID: PMC7962796.
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Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future.

Circulation. Genomic and precision medicine

Ingelsson E, McCarthy MI.
PMID: 29899044
Circ Genom Precis Med. 2018 Jun;11(6):e002090. doi: 10.1161/CIRCGEN.118.002090.

Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk factors for cardiovascular disease, and are destined to increase in importance given the global changes in lifestyle. Ten years have passed since the first...

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Ingelsson E, McCarthy MI. Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future. Circ Genom Precis Med. 2018;11(6):e002090doi: 10.1161/CIRCGEN.118.002090.
Ingelsson, E., & McCarthy, M. I. (2018). Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future. Circulation. Genomic and precision medicine, 11(6), e002090. https://doi.org/10.1161/CIRCGEN.118.002090
Ingelsson, Erik, and McCarthy, Mark I. "Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future." Circulation. Genomic and precision medicine vol. 11,6 (2018): e002090. doi: https://doi.org/10.1161/CIRCGEN.118.002090
Ingelsson E, McCarthy MI. Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future. Circ Genom Precis Med. 2018 Jun;11(6):e002090. doi: 10.1161/CIRCGEN.118.002090. PMID: 29899044; PMCID: PMC6405228.
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Showing 1 to 6 of 6 entries