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The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.

JAMA psychiatry

Giannakopoulou O, Lin K, Meng X, Su MH, Kuo PH, Peterson RE, Awasthi S, Moscati A, Coleman JRI, Bass N, Millwood IY, Chen Y, Chen Z, Chen HC, Lu ML, Huang MC, Chen CH, Stahl EA, Loos RJF, Mullins N, Ursano RJ, Kessler RC, Stein MB, Sen S, Scott LJ, Burmeister M, Fang Y, Tyrrell J, Jiang Y, Tian C, McIntosh AM, Ripke S, Dunn EC, Kendler KS, Walters RG, Lewis CM, Kuchenbaecker K.
PMID: 34586374
JAMA Psychiatry. 2021 Nov 01;78(11):1258-1269. doi: 10.1001/jamapsychiatry.2021.2099.

IMPORTANCE: Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations.OBJECTIVE: To investigate...

Cite
Giannakopoulou O, Lin K, Meng X, et al. The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study. JAMA Psychiatry. 2021;78(11):1258-1269doi: 10.1001/jamapsychiatry.2021.2099.
Giannakopoulou, O., Lin, K., Meng, X., Su, M. H., Kuo, P. H., Peterson, R. E., Awasthi, S., Moscati, A., Coleman, J. R. I., Bass, N., Millwood, I. Y., Chen, Y., Chen, Z., Chen, H. C., Lu, M. L., Huang, M. C., Chen, C. H., Stahl, E. A., Loos, R. J. F., Mullins, N., Ursano, R. J., Kessler, R. C., Stein, M. B., Sen, S., Scott, L. J., Burmeister, M., Fang, Y., Tyrrell, J., Jiang, Y., Tian, C., McIntosh, A. M., Ripke, S., Dunn, E. C., Kendler, K. S., Walters, R. G., Lewis, C. M., Kuchenbaecker, K. (2021). The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study. JAMA psychiatry, 78(11), 1258-1269. https://doi.org/10.1001/jamapsychiatry.2021.2099
Giannakopoulou, Olga, et al. "The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study." JAMA psychiatry vol. 78,11 (2021): 1258-1269. doi: https://doi.org/10.1001/jamapsychiatry.2021.2099
Giannakopoulou O, Lin K, Meng X, Su MH, Kuo PH, Peterson RE, Awasthi S, Moscati A, Coleman JRI, Bass N, Millwood IY, Chen Y, Chen Z, Chen HC, Lu ML, Huang MC, Chen CH, Stahl EA, Loos RJF, Mullins N, Ursano RJ, Kessler RC, Stein MB, Sen S, Scott LJ, Burmeister M, Fang Y, Tyrrell J, Jiang Y, Tian C, McIntosh AM, Ripke S, Dunn EC, Kendler KS, Walters RG, Lewis CM, Kuchenbaecker K. The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study. JAMA Psychiatry. 2021 Nov 01;78(11):1258-1269. doi: 10.1001/jamapsychiatry.2021.2099. PMID: 34586374; PMCID: PMC8482304.
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Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos.

BMC obesity

Fernández-Rhodes L, Howard AG, Graff M, Isasi CR, Highland HM, Young KL, Parra E, Below JE, Qi Q, Kaplan RC, Justice AE, Papanicolaou G, Laurie CC, Grant SFA, Haiman C, Loos RJF, North KE.
PMID: 30305909
BMC Obes. 2018 Oct 02;5:26. doi: 10.1186/s40608-018-0200-x. eCollection 2018.

BACKGROUND: Genome-wide association studies have implicated the METHODS: Using 9031 Hispanic/Latino adults (21-76 years) with complete weight history and genetic data from the community-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Baseline 2008-2011), we estimated the multivariable association between...

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Fernández-Rhodes L, Howard AG, Graff M, et al. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC Obes. 2018;5:26doi: 10.1186/s40608-018-0200-x.
Fernández-Rhodes, L., Howard, A. G., Graff, M., Isasi, C. R., Highland, H. M., Young, K. L., Parra, E., Below, J. E., Qi, Q., Kaplan, R. C., Justice, A. E., Papanicolaou, G., Laurie, C. C., Grant, S. F. A., Haiman, C., Loos, R. J. F., & North, K. E. (2018). Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC obesity, 526. https://doi.org/10.1186/s40608-018-0200-x
Fernández-Rhodes, Lindsay, et al. "Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos." BMC obesity vol. 5 (2018): 26. doi: https://doi.org/10.1186/s40608-018-0200-x
Fernández-Rhodes L, Howard AG, Graff M, Isasi CR, Highland HM, Young KL, Parra E, Below JE, Qi Q, Kaplan RC, Justice AE, Papanicolaou G, Laurie CC, Grant SFA, Haiman C, Loos RJF, North KE. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC Obes. 2018 Oct 02;5:26. doi: 10.1186/s40608-018-0200-x. eCollection 2018. PMID: 30305909; PMCID: PMC6167893.
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