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Hyperuricemia in Kidney Disease: A Major Risk Factor for Cardiovascular Events, Vascular Calcification, and Renal Damage.

Seminars in nephrology

Ejaz AA, Nakagawa T, Kanbay M, Kuwabara M, Kumar A, Garcia Arroyo FE, Roncal-Jimenez C, Sasai F, Kang DH, Jensen T, Hernando AA, Rodriguez-Iturbe B, Garcia G, Tolan DR, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ.
PMID: 33678312
Semin Nephrol. 2020 Nov;40(6):574-585. doi: 10.1016/j.semnephrol.2020.12.004.

Kidney disease, especially when it is associated with a reduction in estimated glomerular filtration rate, can be associated with an increase in serum urate (uric acid), suggesting that hyperuricemia in subjects with kidney disease may be a strictly secondary...

Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease.

Frontiers in aging neuroscience

Johnson RJ, Gomez-Pinilla F, Nagel M, Nakagawa T, Rodriguez-Iturbe B, Sanchez-Lozada LG, Tolan DR, Lanaspa MA.
PMID: 33024433
Front Aging Neurosci. 2020 Sep 11;12:560865. doi: 10.3389/fnagi.2020.560865. eCollection 2020.

The loss of cognitive function in Alzheimer's disease is pathologically linked with neurofibrillary tangles, amyloid deposition, and loss of neuronal communication. Cerebral insulin resistance and mitochondrial dysfunction have emerged as important contributors to pathogenesis supporting our hypothesis that cerebral...

Fructose and Uric Acid as Drivers of a Hyperactive Foraging Response: A Clue to Behavioral Disorders Associated with Impulsivity or Mania?.

Evolution and human behavior : official journal of the Human Behavior and Evolution Society

Johnson RJ, Wilson WL, Bland ST, Lanaspa MA.
PMID: 33994772
Evol Hum Behav. 2021 May;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 Oct 01.

Several behavioral disorders, including attention deficit hyperactivity disorder (ADHD), bipolar disorder, and aggressive behaviors are linked with sugar intake and obesity. The reason(s) for this association has been unclear. Here we present a hypothesis supporting a role for fructose,...

Fructose contributes to the Warburg effect for cancer growth.

Cancer & metabolism

Nakagawa T, Lanaspa MA, Millan IS, Fini M, Rivard CJ, Sanchez-Lozada LG, Andres-Hernando A, Tolan DR, Johnson RJ.
PMID: 32670573
Cancer Metab. 2020 Jul 10;8:16. doi: 10.1186/s40170-020-00222-9. eCollection 2020.

Obesity and metabolic syndrome are strongly associated with cancer, and these disorders may share a common mechanism. Recently, fructose has emerged as a driving force to develop obesity and metabolic syndrome. Thus, we assume that fructose may be the...

Showing 1 to 4 of 4 entries