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Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy.

Oncotarget

He L, Fan Y, Xiao W, Chen T, Wen J, Dong Y, Wang Y, Li S, Xue R, Zheng L, He JC, Wang N.
PMID: 29340054
Oncotarget. 2017 Nov 30;8(67):111295-111308. doi: 10.18632/oncotarget.22784. eCollection 2017 Dec 19.

Hyperuricemia contributes to kidney tubular injury and kidney fibrosis. However, the underlying mechanism remains unclear. Here we examined the role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein and ER stress in hyperuricemic nephropathy. We first found the expression...

Showing 1 to 1 of 1 entries